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  • 1
    Digitale Medien
    Digitale Medien
    Solid waste production from rainbow trout, Salmo gairdneri Richardson, cage culture (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Aquaculture research 16 (1985), S. 0 
    Details
    ISSN: 1365-2109
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract. There is increasing concern over the environmental impact of freshwater cage culture, but there is a lack of information on the amounts and nature of the wastes produced. This study presents measurements of the total solid waste arid solid carbon, nitrogen and phosphorus loadings from five Scottish rainbow trout, Salmo gairdneri Richardson, cage farms, and shows a significant input of solids below the cages. The results indicate a considerable variability in solid output which was partly due to variations in the feeding rate of fish with the cages, but was also thought to be due to variations in management on individual farms. The results compare well with other studies on land-based pond and tank systems and provide useful estimates of solid waste loadings for the prediction of environmental impact.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2109.1985.tb00296.x
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  • 2
    Digitale Medien
    Digitale Medien
    DNA binding of Escherichia coli arginine repressor mutants altered in oligomeric state (1997)
    Oxford UK : Blackwell Science Ltd
    Molecular microbiology 24 (1997), S. 0 
    Details
    ISSN: 1365-2958
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: The Escherichia coli arginine repressor (ArgR) controls expression of the arginine biosynthetic genes and acts as an accessory protein in Xer site-specific recombination at cer and related plasmid recombination sites. The hexameric wild-type protein shows L-arginine-dependent DNA binding. In this work, ArgR mutants that are defective in trimer–trimer interactions and bind DNA as trimers in an L-arginine-independent manner are isolated and characterized. Whereas the wild-type ArgR hexamer exhibits high-affinity binding to two repeated ARG boxes separated by 3 bp (each ARG box containing two identical dyad symmetrical 9 bp half-sites), the trimeric mutants bind to and footprint three adjacent half-sites of this ‘idealized’ substrate. Trimeric ArgR is impaired in its ability to repress the arginine biosynthetic genes and in Xer site-specific recombination. In the absence of L-arginine, residual wild-type ArgR-binding occurs as trimers. The binding of an N-terminal 77-amino-acid DNA-binding domain to idealized ARG boxes is also characterized.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2958.1997.4301791.x
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  • 3
    Digitale Medien
    Digitale Medien
    Mutant Escherichia coli arginine repressor proteins that fail to bind l-arginine, yet retain the ability to bind their normal DNA-binding sites (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 13 (1994), S. 0 
    Details
    ISSN: 1365-2958
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: The Escherichia coli arginine repressor (ArgR) is an l-arginine-dependent DNA-binding protein that controls expression of the arginine biosynthetic genes and is required as an accessory protein in Xer site-specific recombination at cer and related recombination sites in plasmids. Site-directed mutagenesis was used to isolate two mutants of E. coli ArgR that were defective in arginine binding. Results from in vivo and in vitro experiments demonstrate that these mutants still act as repressors and bind their specific DNA sequences in an arginine-independent manner. Both mutants support Xer site-specific recombination at cer. One of the mutant proteins was purified and shown to bind to its DNA target sequences in vitro with different affinity and as a different molecular species to wild-type ArgR.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2958.1994.tb00455.x
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  • 4
    Digitale Medien
    Digitale Medien
    THE EFFECTS OF THYROXINE TREATMENT ON SLOW- AND FAST-CONTRACTING SKELETAL MUSCLE CONTRACTIONS OF THE CAT AND THEIR CYCLIC AMP LEVEL (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 19 (1992), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The effects of thyroxine treatment on soleus and extensor digitorum longus (EDL) muscle contractions and their cyclic adenosine 3′,5′-monophosphate (cyclic AMP) levels were examined in anaesthetized cats.2. Thyroxine treatment decreased the tension of incomplete tetanic contractions of the soleus as well as the EDL muscles. The effect on tension of these muscles was not associated with an increase in the cyclic AMP level of the muscle as is the case with a β2-adrenoceptor agonist effect.3. The results do not support the involvement of cyclic AMP in the tension depressant effect of thyroxine on contractions of skeletal muscle.4. It is suggested that the muscle weakness and tremor observed in thyrotoxicosis and during administration of β-adrenoceptor agonists are mediated by different mechanisms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1992.tb00424.x
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  • 5
    Digitale Medien
    Digitale Medien
    THE EFFECTS OF SIMULTANEOUS ATROPINE AND LABETALOL ADMINISTRATION ON CARDIOVASCULAR PARAMETERS DURING ANTICHOLINESTERASE POISONING IN ANAESTHETIZED CAT (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The effects of atropine administration during anticholinesterase poisoning on heart rate, blood pressure and electrocardiographic changes (ECG) were studied in the cat.2. Administration of atropine intravenously during anticholinesterase poisoning caused a significant increase in heart rate and blood pressure; ECG changes were also seen.3. The simultaneous intravenous administration of atropine and labetalol during anticholinesterase poisoning abolished the increase in blood pressure and heart rate; ECG readings remained normal.4. It is suggested that labetalol may be a useful adjuvant in the treatment of anticholinesterase poisoning especially in patients with compromised heart function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb00950.x
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  • 6
    Digitale Medien
    Digitale Medien
    THE EFFECT OF CORTICOSTEROID PRETREATMENT IN VIVO ON THE CONTRACTION OF GUINEA-PIG ILEUM AND DUODENUM (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The effects of corticosteroid pretreatment on the contraction caused by acetylcholine or electrical stimulation of guinea-pig ileum and duodenum were studied.2. The acetylcholine dose-response curves for steroid pretreated ileum but not duodenum were significantly shifted to the right; evidence that pretreated ileum required higher dose of acetylcholine than normal to cause 50% maximal contraction.3. Naloxone enhanced the contraction of normal ileum caused by acetylcholine given at the dose of ED50, but not that of normal duodenum.4. The dose of morphine required to abolish electrically induced contraction was higher in steroid pretreated ileum than in normal ileum.5. Hence, corticosteroid pretreatment may affect intestinal contractility via opioidergic mechanisms which are found in the ileum but not in the duodenum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb00954.x
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  • 7
    Digitale Medien
    Digitale Medien
    FURTHER EVIDENCE OF THE ROLE OF CYCLIC AMP AS A MEDIATOR OF THE DEPRESSANT EFFECTS OF β-ADRENOCEPTOR AGONISTS AND PHOSPHODIESTERASE INHIBITORS ON SLOW-CONTRACTING MAMMALIAN SKELETAL MUSCLES (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The depressant effects of β-adrenoceptor agonists and phosphodiesterase inhibitors on contractions of slow-contracting mammalian skeletal muscles are associated with increased muscular cyclic AMP levels.2. A strong correlation was found to exist between the percentage depression of contraction and the percentage increase in cyclic AMP level, irrespective of the drug used and regardless of the mechanism of cyclic AMP production.3. The results strongly support the mediatory role of cyclic AMP in the depressant effects of β-adrenoceptor agonists and phosphodiesterase inhibitors on slow-contracting mammalian skeletal muscle contractions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb00924.x
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  • 8
    Digitale Medien
    Digitale Medien
    THE EFFECTS OF NALOXONE, DEXAMETHASONE, DEOXYCORTICOSTERONE AND 17-HYDROXYPROGESTERONE ON BLOOD PRESSURE RESPONSES OF NORMAL AND ADRENALECTOMIZED RATS DURING HYPOVOLAEMIC SHOCK (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY1. The roles of, and interactions between, steroids and naloxone, an opioid antagonist, in the reversal of experimental hypotensive shock were studied in normal and adrenalectomized rats.2. In normal rats treated with dexamethasone or deoxycorticosterone or 17-hydroxyprogesterone the hypotension and shock caused by 1% bodyweight and 2% bodyweight haemorrhage could be substantially reversed by naloxone in a dose-related manner. In contrast, the reversal of hypotension by naloxone was markedly less in adrenalectomized rats.3. It is concluded that there is a co-ordinate release of pressor catecholamines and depressor enkephalins from adrenal glands in hypovolaemic shock. Eventually, the use of naloxone would be of much less value in the treatment of hypotension or shock in patients with Addison's disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb00964.x
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  • 9
    Digitale Medien
    Digitale Medien
    EFFECTS OF α- AND β-ADRENOCEPTOR AGONISTS AND A PHOSPHODIESTERASE INHIBITOR (ICI 63 197) ON CYCLIC AMP AND GMP LEVELS IN BOVINE SPLENIC NERVE (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 10 (1983), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Cyclic AMP and cyclic GMP levels were determined in bovine splenic nerve segments in the absence and presence of (±) - isoprenaline, (-)-phenylephrine, clonidine and ICI 63 197 (a phosphodiesterase inhibitor). The chosen concentrations of adrenoceptor agonists were those which are known to affect stimulation-induced overflow of noradrenaline from nerve terminals.2. The mean levels of cyclic AMP ranged from 229 to 555 pmol/g of microwave irradiated tissue. Mean cyclic GMP levels ranged from 27.9 to 42.2 pmol/g.3.Isoprenaline enhanced cyclic AMP levels but did not affect cyclic GMP levels. The effect was blocked with (±)-propranolol. ICI 63 197 increased cyclic AMP levels but did not change cyclic GMP. Phenylephrine and clonidine caused no consistent changes in cyclic AMP or cyclic GMP levels or in the concentration ratio between these two nucleotides.4.The results support the involvement of cyclic AMP in the enhancing effect of β-adrenoceptor agonists and phosphodiesterase inhibitors on stimulation-induced release of noradrenaline from sympathetic nerves.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1983.tb00169.x
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  • 10
    Digitale Medien
    Digitale Medien
    EFFECTS OF ISOPRENALINE, LEVODOPA AND A PHOSPHODIESTERASE INHIBITOR (ICI 63,197) ON CYCLIC AMP LEVELS AND CONTRACTIONS OF SOLEUS MUSCLES IN ANAESTHETIZED CATS (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Cyclic AMP levels have been determined in the soleus muscles of anaesthetized cats in the absence of drugs, and during depression of incomplete tetanic contractions produced by (-)-isoprenaline, ICI 63,197 (a phosphodiesterase inhibitor) or levodopa.2. Cyclic AMP levels were elevated at the peak of tension depression produced by isoprenaline. Effects of isoprenaline on cyclic AMP and on contractions were dose dependent and statistically significantly related one to the other. Both effects were blocked by propranolol.3. ICI 63,197 and levodopa produced isoprenaline-like effects on contractions but times to peak effect and recovery were longer. Cyclic AMP levels estimated during the depressant action were elevated.4. The results support the involvement of cyclic AMP in the depressant effect of β-adrenoreceptor agonists on slow-contracting mammalian skeletal muscle.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1981.tb00134.x
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