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  • Electronic books.  (258)
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  • 11
    Schlagwort(e): Chemistry. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (561 pages)
    Ausgabe: 1st ed.
    ISBN: 9783709171660
    Serie: Fortschritte der Chemie Organischer Naturstoffe Progress in the Chemistry of Organic Natural Products Series ; v.12
    Sprache: Englisch
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 12
    Online-Ressource
    Online-Ressource
    London :Bloomsbury Publishing Plc,
    Schlagwort(e): Birds-Scotland. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (286 pages)
    Ausgabe: 1st ed.
    ISBN: 9781408137352
    Serie: Poyser Monographs
    DDC: 598.3/3
    Sprache: Englisch
    Anmerkung: Cover -- Copyright Page -- Contents -- List of tables -- List of appendices -- List of plates -- List of figures -- Preface -- Authors' preface -- Acknowledgements -- Chapter 1 The Greenshank -- Chapter 2 The Family -- Chapter 3 Greenshank Country -- Chapter 4 Nest Hunting -- Chapter 5 Individual Greenshanks -- Chapter 6 Groups, Populations and Breeding Density -- Chapter 7 Voice -- Chapter 8 Territory and Dispersion -- Chapter 9 Courtship and Displays -- Chapter 10 Nest -- Chapter 11 Egg, Clutch and Laying Season -- Chapter 12 Brooding and Hatching -- Chapter 13 Young -- Chapter 14 Feeding Habitats, Feeding Behaviour and Food -- Chapter 15 Predators -- Chapter 16 The Breeding Habitat of The Greenshank in Scotland -- Chapter 17 Distribution, Numbers and Movements -- Chapter 18 Progress -- Bibliography -- Tables -- Appendix 1 Description of nesting territories -- Appendix 2 Nest sites and nest linings (D. A. Ratcliffe) -- Appendix 3 Egg-laying notes and observations -- Appendix 4 Analysis of unhatched greenshank egg -- Appendix 5 Food (Glutz 1977) -- Appendix 6 Ringing recoveries (R. Spencer, BTO) -- Appendix 7 Ectoparasites -- Appendix 8 Endoparasites (Parasitic Worms) -- Appendix 9 Hut diary for 21 May 1977 -- Appendix 10 Note on the interpretation of the sound spectrograms -- Appendix 11 World breeding and wintering ranges of greenshank T. nebularia and greater yellowlegs T. melanoleuca -- Colour plates -- Plates.
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  • 13
    Online-Ressource
    Online-Ressource
    Blue Ridge Summit :Globe Pequot Press, The,
    Schlagwort(e): Waterfalls. ; Electronic books.
    Beschreibung / Inhaltsverzeichnis: Fully revised and updated, Hiking Waterfalls Virginia includes detailed descriptions, maps, and color photos for approximately 50 of the most scenic waterfall hikes in the state. Complete with history, local trivia, and GPS coordinates, hike descriptions include city, state, and national parks, as well as monuments and wilderness areas featuring spectacular waterfalls.
    Materialart: Online-Ressource
    Seiten: 1 online resource (201 pages)
    Ausgabe: 2nd ed.
    ISBN: 9781493063598
    Serie: Hiking Waterfalls Series
    DDC: 796.5109755
    Sprache: Englisch
    Anmerkung: Intro -- Contents -- Introduction -- How to Use This Guide -- Trail Finder -- Map Legend -- Southwest Virginia -- 1 Three Falls on the Little Stony -- 2 Big Falls -- 3 Tank Hollow Falls -- 4 Three Falls on Tumbling Creek -- 5 Big Rock Falls -- 6 Waterfall on Wilson Creek -- 7 Two Falls on Cabin Creek -- 8 Comers Creek Falls -- 9 Fox Creek Falls -- 10 Waterfall on Garrett Creek -- 11 Falls of Dismal -- Valley and Ridge -- 12 Waterfall at Falls Ridge -- 13 The Cascades -- 14 Roaring Run Falls -- 15 Falling Spring Falls -- 16 Stony Run Falls -- 17 Blue Suck Falls -- 18 Hone Quarry Falls -- 19 Falls on Tributary to Middle River -- 20 Cypress Falls -- 21 Lace Falls -- Blue Ridge Parkway -- 22 St. Mary's Falls -- 23 White Rock Falls -- 24 Crabtree Falls -- 25 Wigwam Falls -- 26 Statons Creek Falls -- 27 Panther Falls -- 29 Apple Orchard Falls -- 29 Fallingwater Cascades -- 30 Bent Mountain Falls -- Shenandoah National Park -- North District -- 31 Lands Run Falls -- 32 Overall Run Falls -- Central District -- 33 Hazel Falls -- 34 Six Falls of Whiteoak Canyon -- 35 Four Falls on Cedar Run -- 36 Rose River Falls -- 37 Dark Hollow Falls -- 38 Lewis Falls -- 39 Big Rock Falls (SNP) -- 40 South River Falls -- South District -- 41 Two Waterfalls on Doyles River -- 42 Jones Run Falls -- 43 Waterfall on Big Branch -- Piedmont -- 44 Forest Hill Park Dam -- 45 Waterfall at Maymont -- 46 Falls of the Nottoway -- Northern Virginia -- 47 Scott's Run Falls -- 48 Great Falls -- The Art of Hiking -- Hike Index -- About the Author.
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  • 14
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing AG,
    Schlagwort(e): College teaching. ; Electronic books.
    Beschreibung / Inhaltsverzeichnis: This book gives guidance and resources for creating a disciplinary-based teaching and learning center and conducting professional development activities specifically tailored for science faculty and graduate students.
    Materialart: Online-Ressource
    Seiten: 1 online resource (238 pages)
    Ausgabe: 1st ed.
    ISBN: 9783319016528
    DDC: 507.1073
    Sprache: Englisch
    Anmerkung: Intro -- Foreword -- Acknowledgment -- Contents -- About the Authors -- 1 Discipline-Based Professional Development -- Transforming Undergraduate Science Education -- Active Learning and Evidence-Based Teaching Approaches -- Professional Development for Teaching in the University -- Pedagogical Content Knowledge -- The Five PCK Components -- PCK for the Undergraduate Level -- Overview and Brief History of the Teaching and Learning Center (TLC) -- Key Contributors to a Disciplinary TLC -- Institutional Levels and External Entities Involved in Change Efforts -- Credibility and Buy-In -- How to Initiate a Disciplinary TLC -- Outline of the Book -- References -- 2 Building Interest and Engagement Through Enrichment Activities -- Visiting Teacher/Scholars -- Characteristics of Visiting Teacher/Scholars -- Activities with Visiting Teacher/Scholars -- Seminars and Workshops -- Guiding Principals in Developing Seminars and Workshops -- Selecting Seminar and Workshop Topics -- Evaluation of Seminars and Workshops -- PCK Focus of Seminars and Workshops -- PCK 1: Student Understanding of Science -- PCK 2. Science Curriculum -- PCK 3. Instructional Strategies -- PCK 4. Assessment of Student Learning -- PCK 5. Orientation to Teaching Science -- Conclusion -- Implementation Guide -- Tips for Hosting a Successful Teacher/Scholar Visit -- Selecting and Recruiting Visiting Teacher/Scholars -- Publicizing the Visit -- Creating an Agenda of Activities -- Example Seminars and Workshops by PCK Component -- PCK 1: Overcoming Students' Alternative Conceptions in the Chemical and Life Sciences -- PCK 2: Undergraduate Curriculum Innovations in the College of Chemical and Life Sciences -- PCK 3: Blended Learning: What It Is and How to Use It -- PCK 4: As You Can See, But Students Don't: A Closer Look at How Students Read and Interpret Graphic Information. , PCK 5: Identifying the Hallmarks of Effective Teaching to Create a Rubric for Peer Review of Teaching -- Following the Workshop -- References -- 3 Acculturation of New Faculty Members -- Preparation and Work Context of New Faculty Members -- Getting to Know Our New Faculty Members -- Overview of the New Faculty Longitudinal Study -- Analysis of Study Findings by PCK Component -- PCK 1: Student Understanding of Science -- PCK 2: Science Curriculum -- PCK 3: Instructional Strategies -- PCK 4: Assessment of Student Learning -- PCK 5: Orientation to Teaching Science -- Professional Development for New Faculty Members -- Welcome Workshop -- Seminars and Workshops -- Individual Consulting -- Connections to Networks and Faculty Learning Communities -- Funding Opportunities -- Conclusion -- Implementation Guide -- Longitudinal Study: Interview Protocols -- Initial Interview Protocol -- Follow-up Interview Protocol -- Welcome Workshop -- Welcome Workshop Outline -- Welcome Packet -- References -- 4 Consultation for Individuals and Groups of Faculty -- The Need for Ongoing Professional Development -- Bridging the Gap Through Professional Development -- Our Model for Consulting -- Consultation for Individuals -- Consultation for Groups of Faculty -- Informal Groups of Faculty -- Faculty Learning Communities -- Conclusion -- Implementation Guide -- Consultation for Individuals -- PCK 1: Knowledge of Student Understanding -- PCK 2: Knowledge of Science Curriculum -- PCK 3: Knowledge of Instructional Strategies -- PCK 4: Knowledge of Assessment -- PCK 5: Orientation to Science Teaching -- Consultation for Faculty Learning Communities -- PCK 1: Knowledge of Student Understanding -- PCK 2: Knowledge of Science Curriculum -- PCK 3: Knowledge of Instructional Strategies -- PCK 4: Knowledge of Assessment -- PCK 5: Orientation to Science Teaching -- References. , 5 Preparing Graduate Students for Their Teaching Responsibilities -- Need for Training -- Types of Training Currently Offered -- Short Workshops for Beginning GTAs -- Longer Preparatory or Support Course -- Teaching as Professional Development -- Being Observed -- Observation of Experienced Teachers -- Certificate Programs -- National Professional Development Networks -- Professional Development for GTAs in Our University -- Needs Assessment -- Key Findings from the Survey -- Feedback from the Workshop on Roles of the GTA -- Our Professional Development Programs for GTAs -- Seminars and Workshops -- Mandatory Six-Week Courses for New GTAs -- Optional Two-Credit Course -- Certificate Program in Teaching and Learning -- Conclusion -- Implementation Guide -- Workshop: The Role of the GTA -- Summary of GTA Needs Assessment Survey Results -- Conversations on GTA Roles and Challenges -- Conversations on Enhancing GTA Professional Development -- Experiences with Innovative Course Redesigns -- Mandatory Six-Week Teaching Preparatory Course -- Session 1: Introduction and Overview of the Role of the GTA in Undergraduate Education -- Session 2: Student-GTA Communication -- Session 3: Assessing Student Performance -- Session 4: Engaging Students Through Effective Teaching -- Session 5: Evaluation and Expectations of the GTA -- Session 6: Special Topics Based on GTA Interests -- 2-Credit Course for Graduate Students -- Session 1: Introduction to the Course -- Session 2: Overview of Science Education -- Session 3: Student Diversity in Learning Styles and Multiple Intelligences -- Sessions 4 and 5: Theories in Science Education -- Session 6: Active Learning and Evidence-Based Teaching Approaches -- Session 7: Assessment, Rubrics, and Grading -- Session 8: Students' Alternative Conceptions -- Session 9: Using Visual Representations-Concept Maps and Models. , Session 10: Using Technology in Science Education -- Session 11: Observation of an Undergraduate Science Class -- Sessions 12-14: Presentations of Teachable Units -- References -- 6 Evaluating the Effectiveness of a Teaching and Learning Center -- The Role of Comprehensive Program Evaluation -- Needs Assessment: A First Step -- Stakeholders and Their Input into the TLC Needs Assessment -- Final Steps of the Needs Assessment Process -- Ongoing Evaluation: Measuring Five Levels of Program Impact -- Level 1: Participation -- How Do Participants Know About the TLC and Its Activities? -- Who Participates and in What Do They Participate? -- Why Do Individuals Participate? -- Level 2: Satisfaction -- Assessing the Achievement of Programmatic Goals -- Assessing Participant Satisfaction -- Level 3: Learning -- Stage 1: Knowledge of Evidence-Based Teaching Practices -- Stage 2: Belief in the Effectiveness of Evidence-Based Teaching Practices in Enhancing Student Learning -- Stage 3: An Understanding of How to Employ Evidence-Based Teaching Practices -- Level 4: Application -- Faculty Self-Reports of the Teaching Practices They Used -- Student Reports of Teaching Practices They Experienced -- Classroom Observations -- Level 5: Impact -- Student Satisfaction with Their Courses and Course Instruction -- Student Attitudes and Beliefs About Science -- Student Learning in Courses and Sequences of Courses -- Conclusion -- Implementation Guide -- Guiding Questions for Departmental Meetings-Needs Assessment -- Sample Completed Faculty Learning Community Observation Protocol -- References -- 7 Concluding Thoughts -- Lessons Learned.
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  • 15
    Schlagwort(e): Energy industries-Congresses. ; Petroleum industry and trade-Congresses. ; Fuel-Prices-Congresses. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (703 pages)
    Ausgabe: 1st ed.
    ISBN: 9781000002232
    DDC: 333.79
    Sprache: Englisch
    Anmerkung: Cover -- Title Page -- Copyright Page -- Contents -- Editors' Preface -- PART l: SHORT-TERM OIL MARKETS AND PRICES -- 1 The Political Economy of World Petroleum -- 2 Prospects for World Oil Markets -- 3 Short-Term Petroleum Outlook: Refiner and OPEC Behavior -- 4 The Impact of a Dollar Decline on the U.S. Economy and Energy Industries -- 4 The Impact of a Dollar Decline on the U.S. Economy and Energy Industries -- 4 The Impact of a Dollar Decline on the U.S. Economy and Energy Industries -- 7 The Costs and Benefits of a Gasoline Tariff -- 8 Economic and Legal Considerations for Oil and Gas Producers in Declining Markets -- PART 2: LONG-TERM OIL MARKETS AND PRICES -- 9 Worldwide Oil and Gas: Permanent Instability -- 10 The Long-Term Implications of Oil as a Commodity -- 11 The World Energy Outlook -- 12 The World Oil Market to the Year 2000 -- 13 Precursors for High and Low Future World Oil Prices -- 14 Economic Theory and World Energy Markets in the 1990s -- 15 On the Pricing of Oil: The Effects of Market Fragmentation -- 16 Crude Oil Trading and Price Stability -- PART 3: NATURAL GAS MARKETS AND PRICES -- 17 The Evolution of Natural Gas Markets -- 18 How Will Natural Gas Be Priced? -- 19 The North American Gas Market: Key Developments and Observations -- 20 Natural Gas in Western Europe: Major Expansion in Prospect -- 21 The Interplay of State and Federal Issues in Natural Gas -- 22 can the Gas Industry Weather FERC's New Rules? -- 23 Comment on Notice of Proposed Rule-Making Regulation of Natural Gas AfterPartial Wellhead Decontrol -- 24 Natural Gas: An Expanded Role for the Future -- PART 4: COAL AND ELECTRICITY -- 25 Coal and Electric Utilities Market Assessment Outlook -- 26 The Role of U.S. Coal in the International Coal Market -- 27 Prospects for the French Power Sector Through the Year 2000. , 28 Exporting Blue Gold: Who Will Absorb the Forecast Risk? -- 29 Deregulate the Electric Industry -- 30 Planning to Meet Future Electricity Demand: A Look at the Economics of the Nuclear and Coal Option -- 31 The Current Economics of Coal and Nuclear Power in the United States -- 32 Avoided Cost Pricing: New Ideas for a New Era -- 33 Impact of Lower and Falling Oil Prices on Emerging Power Generation Technologies -- PART 5 : ENERGY AND THE ECONOMY -- 34 world Economic outlook -- 35 1985 GRI Baseline Projection of U.S. Energy Supply and Demand: 1984-2010 -- 36 Long-Run Forecasts of Regional Energy Prices with the Argonne Regional Energy Price Simulator (AREPS) -- 37 Long-Run Projections of State-Level Conanercial and Residential Energy Use -- 38 Choice of Technology and Long-Run Technical Change in Energy Intensive Industries -- 39 A Weather Index for International Heating Oil Consumption -- 40 Decision Making Under Uncertainty in Thailand's Energy Sector -- 41 An Energy-Economy Model for Pakistan -- 42 Urban Energy Use in the Developing Countries.
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  • 16
    Online-Ressource
    Online-Ressource
    New York :Columbia University Press,
    Schlagwort(e): Self. ; Electronic books.
    Beschreibung / Inhaltsverzeichnis: Cognitive science joins with Asian contemplative traditions and philosophy to bring revolutionary meaning to the human experience.
    Materialart: Online-Ressource
    Seiten: 1 online resource (497 pages)
    Ausgabe: 1st ed.
    ISBN: 9780231538312
    DDC: 612.8
    Sprache: Englisch
    Anmerkung: Intro -- Table of Contents -- Foreword by Stephen Batchelor -- Prologue: The Dalai Lama's Conjecture -- Acknowledgments -- Introduction -- 1. Seeing: What Is Consciousness? -- 2. Waking: How Do We Perceive? -- 3. Being: What Is Pure Awareness? -- 4. Dreaming: Who Am I? -- 5. Witnessing: Is This a Dream? -- 6. Imagining: Are We Real? -- 7. Floating: Where Am I? -- 8. Sleeping: Are We Conscious in Deep Sleep? -- 9. Dying: What Happens When We Die? -- 10. Knowing: Is the Self an Illusion? -- Notes -- Bibliography -- Index.
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  • 17
    Online-Ressource
    Online-Ressource
    London :Taylor & Francis Group,
    Schlagwort(e): Galenson, Eleanor, -- 1916-2011. ; Sex differentiation. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (281 pages)
    Ausgabe: 1st ed.
    ISBN: 9781782412465
    Serie: The International Psychoanalytical Association Psychoanalytic Ideas and Applications Series
    DDC: 616.8917
    Sprache: Englisch
    Anmerkung: Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Acknowledgements -- About the Editor and Contributors -- Introduction -- Prologue Interview with Eleanor Galenson -- Prologue Our children, our future: a conversation with Eleanor Galenson -- Part I Symbolisation, Thought, and Language -- Introduction to Part I -- Chapter One A consideration of the nature of thought in childhood play -- Discussion of Chapter One -- Chapter Two The impact of early sexual discovery on mood, defensive organisation, and symbolisation -- Discussion of Chapter Two -- Chapter Three The influence of hostile aggression on the development of expressive language -- Part II Infantile Origins of Sexual Identity -- Introduction to Part II -- Chapter Four Early genital activity and the castration complex -- Chapter Five Object loss and early sexual development -- Discussion of Chapter Five -- Chapter Six Observation of early infantile sexual and erotic development -- Chapter Seven Review of The Infantile Origins of Sexual Identity -- Chapter Eight Review of The Infantile Origins of Sexual Identity -- Part III The Tripartite Therapeutic Model -- Chapter Nine Treatment of psychological disorders of early childhood: a tripartite therapeutic model -- Chapter Ten Gender disturbance in a three-and-a-half-year-old boy -- Chapter Eleven Psychoanalytic approach to psychotic disturbances in very young children: a clinical report -- Index.
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  • 18
    Online-Ressource
    Online-Ressource
    Calgary :TouchWood Editions,
    Schlagwort(e): Thompson, Margaret,-1940 November 5-. ; Thompson, Margaret,-1940 5 nov.-. ; Human-animal relationships. ; Nature-Effect of human beings on. ; Animals. ; Relations homme-animal. ; Homme-Influence sur la nature. ; Animaux. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (124 pages)
    Ausgabe: 1st ed.
    ISBN: 9781926972015
    DDC: 304.2
    Sprache: Englisch
    Anmerkung: Intro -- Title Page -- Dedication -- Table of Contents -- Epigraph -- Introduction -- In the Beginning -- Pets R Us -- Peacocks and Lilies, For Instance -- Swans -- Animal Behaviour -- Phobia -- Bats -- Dominion -- Sentenced to Life -- Merlin -- Pigs Might Fly -- Goat -- On Cats -- Arctophilia -- Loving a Wall -- The Unready -- Crows -- End Run -- The Fox's Tale -- Companions Afloat -- About the Author -- Copyright.
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  • 19
    Online-Ressource
    Online-Ressource
    Dordrecht :Springer Netherlands,
    Schlagwort(e): Land use -- Environmental aspects. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (427 pages)
    Ausgabe: 1st ed.
    ISBN: 9781402049064
    DDC: 333.73
    Sprache: Englisch
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 20
    Online-Ressource
    Online-Ressource
    Hauppauge :Nova Science Publishers, Incorporated,
    Schlagwort(e): Androgens. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (252 pages)
    Ausgabe: 1st ed.
    ISBN: 9781620811887
    Serie: Endocrinology Research and Clinical Developments
    Sprache: Englisch
    Anmerkung: Intro -- ANDROGENS -- ANDROGENS -- Contents -- Preface -- Androgen Deprivation Therapy for Advanced Prostate Cancer on the Ground of Androgen Milieu in the Prostate -- Abstract -- Abbreviations -- Introduction -- Androgen Milieu in Blood -- Androgen Milieu in the Prostate -- Prostate Cancer Aggressiveness and the Androgen Milieu in the Prostate and in Blood -- Intraprostatic Androgen Milieu during Androgen Deprivation Therapy -- Androgen Milieu in the Castration-Resistant Prostate Cancer -- Clinical-Translational Advances of Prostate Cancer -- Gonadotrophin-Releasing Hormone (GnRH) Antagonists: Degarelix -- Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) Inhibitors -- Abiraterone Acetate (Zytiga, Johnson & -- Johnson) -- Orteronel (TAK-700) [(1S)-1-(6,7-Dimethoxy-2-Naphthyl)-1-(1H-Imidazol-4-Yl)-2-Methylpropan-1-Ol] -- TOK-001 (VN/124-1) [3 -Hydroxy-17-(1H-Benzimidazole-1-Yl)Androsta-5,16-Diene] -- 3.-Hydroxysteroid Dehydrogenase Inhibitors -- Apoptone (HE3235) (17 -Ethynyl-5 -Androstan-3 , 17 -Diol) -- Inhibitors Targeting Androgen Receptor -- A New Androgen Receptor Antagonist, MDV3100 -- A New Androgen Receptor Antagonist, ARN-509 -- An Inhibitor of the Amino Terminal Domain (NTD) of the AR: EPI-001 -- The Prospects of the Androgen Deprivation Therapy on the Ground of Androgen Milieu in the Prostate -- Conclusion -- References -- Clinical Model of Androgen Deficiency - Clinical Model of Androgen Deficiency - Clinical Model of Androgen Deficiency - Androgen Deprivation Therapy and Its Effect on Bone Metabolism, Metabolism and Cognitive Functions -- Introduction -- Methods -- Androgen Deprivation Therapy (ADT) -- Testosterone: A Basal Overview of Biosynthesis, Metabolism and Its Action -- Androgens and Bone Metabolism -- ADT and Its Side Effects -- Bone Loss and Osteoporosis -- Osteoporosis. , Diagnosis of Osteoporosis -- ADT, PCa and Clinical Aspects of Bone Disease -- Treatment of ADT Induced Osteoporosis -- Androgens and Cognitive Functions -- Potential Mechanisms of Action -- Cognitive Functions and ADT -- Androgen Deprivation Therapy and Changes in Body Composition -- ADT and Insulin Resistance -- Early Metabolic Changes -- Late Metabolic Changes -- ADT and Lipid Alterations -- ADT, Metabolic Syndrome and Cardiovascular Disease -- References -- The Role of Testosterone in Male Erectile Dysfunction -- 1. Erectile Dysfunction -- 2. Definitions -- 2.1. Total Testosterone -- 2.2. Free Testosterone -- 2.3. Bio-Available/Bioactive Testosterone -- 3. Hypogonadism -- 3.1. Late Onset Hypogonadism -- 3.2. Hypogonadism Prevalence -- 4. Relationship between Testosterone and ED -- 5. Physiology of Erection -- 6. Influence of Testosterone on Penile Erection -- 6.1. NOS/cGMP Pathway -- 6.2. Source of NO -- 6.3. Phosphodiesterases (PDE) -- 7. Making the Diagnosis of Hypogonadism and Working up Erectile Dysfunction -- Patient History -- Physical Exam -- Laboratory Studies -- Specific Diagnostic Tests -- 7.1. Questionnaires -- 7.2. Laboratory Diagnosis -- 7.3. Total Testosterone -- What is the Lower Level of Testosterone Required to Maintain Erection? -- 7.4. Free Testosterone -- 7.5. Calculated Free Testosterone -- 7.6. Other Endocrine Markers -- 8. Testosterone and Testosterone Replacement Therapy (TRT) -- 8.1. Safety, Tolerability and Specific Considerations -- 8.2. Testosterone and PDE5 Inhibitors (PDE5-I) in ED -- References -- Roles of Androgen Receptor in Normal Prostate Development and Prostate Cancer Progression -- 1. Introduction -- 2. Dual Roles of the AR in Normal Prostate Development -- 2.1. Stromal AR: Proliferation Stimulator and Survival Factor -- 2.2. Epithelial AR: Survival Factor for Epithelial Luminal Cells. , 2.3. Epithelial AR: Suppressor for Epithelial Basal Intermediate Cell Proliferation -- 2.4. Epithelial AR: Survival Factor for Stromal Smooth Muscle Cell Differentiation -- 3. AR Dual Roles in Prostate Cancer Progression and Metastasis -- 3.1. Stromal AR: Stimulator for Tumor Progression and Metastasis -- 3.2. Epithelial AR: Survival Factor for Tumor Progression and Metastasis in Luminal Cells -- 3.3. Epithelial AR: Suppressor for Tumor Progression and Metastasis in Basal Intermediate Cells -- 3.4. Epithelial AR: Suppressor of Prostate Cancer Metastasis -- 4. AR Dual Roles in Human Prostate Cancer Cell Lines -- 4.1. AR in PC3 Cells: Suppressor for Proliferation and Metastasis -- 4.2. AR in LNCaP Cells: Proliferation Stimulator and Suppressor -- 4.3. AR in CWR22Rv1 Cells: Proliferation Stimulator and Suppressor -- 4.4. AR in PC346C Prostate Cancer Cells: Proliferation Stimulator and Suppressor -- 5. AR Dual Roles in Prostate Cancer Stem Cell Progression -- 6. AR Dual Roles and Human Prostate Cancer Clinical Data -- 7. The Impact of AR Dual Roles on Current Clinical ADT -- 7.1. Challenge to Current ADT -- 7.2. Target the AR at an Early Stage -- 7.3. Concomitant Treatment of AR Antagonism with Anti-Metastasis Agents -- Future Direction -- Conclusion -- References -- Endogenous Pathways for Steroidogenesis and Androgen Signalling in Prostate Cancer Cells -- Summary -- Introduction -- The Prostate -- Androgen Receptor -- Prostate Cancer and Treatment -- Links between Androgen Levels and Prostate Cancer Risk -- Steroidogenesis and Prostate Cancer -- Conclusion -- References -- The Role and Effects of Novel Androgen Therapy in the Treatment of Prostate Cancer -- Abstract -- I. Introduction -- II. Emergence of Castration Resistance: Androgen Regulation and Signaling -- III. Clinical Studies. , IV. Adverse Effects of Targeting Androgen Regulation: Recent Findings -- Conclusion -- References -- Androgens and Male Fertility: Spermatogenesis and Contraception -- Abstract -- Introduction -- Androgens -- Role of Androgens in Male Sexual Development -- Spermatogenesis -- Hypthalamic-Pituitary-Gonadal Axis -- Role of the Androgen Receptor -- Classical Testosterone Signaling Pathways -- Non-Classical Testosterone Pathways in Sertoli Cells -- Male Hormone Contraception -- References -- Androgens, Cognition and Social Behavior in Children* -- Introduction -- Androgens -- Testosterone -- Androstenedione -- Dehydroepiandrosterone (DHEA) -- Androgen-Secreting Glands -- Suprarenal Glands -- Gonads -- Testicles -- Ovaries -- Biosynthesis of Steroid Hormones -- Action Mechanisms of Androgens -- Sexual Differentiation of the Brain and Behavior -- Sexual Differentiation -- Genetic Sex -- Gonadal Sex -- Hormonal Sex -- Effects of Organization and Activation -- Relation of Androgens to Psychological Processes -- Relationship between Androgens and Social Behavior -- Conclusion -- References -- Androgens, Androgen Suppression, and Prostate Cancer: Recent Preclinical and Clinical Findings and Implications* -- Abstract -- Introduction -- Prevention Studies -- 5-Alpha Reductase Inhibitors -- Treatment Studies -- Role of ADT in Early Prostate Cancer -- ADT Combined with Radiation -- ADT Combined with Surgery -- ADT for Patients Ineligible for Local Definitive Therapy -- Role of Continuous ADT in Biochemical Recurrence of Prostate Cancer -- Early versus Late Therapy -- Peripheral Androgen Blockade -- Role of Continuous ADT in Advanced Disease -- Combined Androgen Blockade -- Antiandrogen Monotherapy -- Antiandrogen Withdrawal -- Intermittent ADT -- Role of Intermittent ADT in Biochemically Recurrent Prostate Cancer. , Role of Intermittent ADT in Locally Advanced or Metastatic Prostate Cancer -- Individual Dosing Based on Testosterone Levels -- Rapid Hormonal Testosterone Cycling -- Other Agents -- Ketoconazole -- Aminoglutethimide -- Abiraterone Acetate -- ADT Combined with Other Modalities -- ADT and Chemotherapy -- ADT and Vaccines -- Adverse Effects of ADT -- Skeletal Changes and Loss of Bone Mineral Density -- Hot Flashes -- Metabolic Syndrome -- Sexual Dysfunction -- Emotional and Cognitive Side Effects -- Systemic Effects -- Biology of Castrate-Resistant Prostate Cancer -- Potentially Therapeutic Approaches Targeting AR -- Conclusion -- References -- Index.
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