Publikationsdatum:
2018-05-05
Beschreibung:
Defining a conformational ensemble that directs activation of PPARγ Defining a conformational ensemble that directs activation of PPARγ, Published online: 04 May 2018; doi:10.1038/s41467-018-04176-x Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor. Here the authors provide insights into PPARγ activation by combining fluorine (19F) NMR and molecular dynamics simulations to characterize the nuclear receptor conformational ensemble in solution and the response of this ensemble to ligand and coregulatory peptide binding.
Digitale ISSN:
2041-1723
Thema:
Biologie
,
Chemie und Pharmazie
,
Allgemeine Naturwissenschaft
,
Physik
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