Anmerkung: Intro -- Foreword -- Preface -- Contents -- List of Contributors -- Investigating the Potential Toxicity of Hydraulic Fracturing Flowback and Produced Water Spills to Aquatic Animals in Freshwat... -- 1 Introduction -- 2 FPW Chemical Characterization -- 2.1 Major Ions -- 2.2 Trace Metals -- 2.3 Organic Chemicals -- 2.4 Wellbore Reaction Products -- 3 FPW Chemical Constituent Toxicity -- 3.1 Major Ion Toxicity -- 3.2 Trace Metal Toxicity -- 3.3 Organic Chemicals -- 3.3.1 Polycyclic Aromatic Hydrocarbons -- 3.3.2 Volatiles -- 3.3.3 Synthetics -- 3.4 Whole FPW Toxicity -- 4 FPW Releases and Regulatory Guideline Considerations -- 5 Conclusions and Future Directions -- References -- Occurrence of Levonorgestrel in Water Systems and Its Effects on Aquatic Organisms: A Review -- 1 Introduction -- 2 Levonorgestrel Detection and Exposure Concentrations in the Aquatic Environment -- 3 Toxicity of Levonorgestrel to Aquatic Organisms -- 3.1 Toxicity of Levonorgestrel to Cyanobacteria -- 3.2 Toxicity of Levonorgestrel to Algae -- 3.3 Toxicity of Levonorgestrel to Zooplankton -- 3.4 Toxicity of Levonorgestrel to Molluscs -- 3.5 Toxicity of Levonorgestrel to Fish -- 3.6 Toxicity of Levonorgestrel to Amphibians -- 4 Aquatic Risk Assessment for Levonorgestrel -- 4.1 Measured Environmental Concentration (MEC) Selection -- 4.2 Effects Assessment -- 4.3 Estimation of Risk Quotients -- 5 Conclusions -- References -- A Review on the Environmental Exposure to Airborne Manganese, Biomonitoring, and Neurological/Neuropsychological Outcomes -- 1 Introduction -- 2 Methods: Literature Search Strategy -- 3 Results -- 3.1 Inhalation of Manganese: Evaluation of Airborne Manganese Levels -- 3.2 Biomarkers of Environmental Exposure to Manganese -- 3.3 Neurological and Neuropsychological Effects Assessed in Environmentally Airborne Manganese-Exposed Population. , 3.3.1 Cognitive Function -- Intelligence and General Cognitive Functioning -- Attention and Cognitive Flexibility -- Executive Functions -- Memory and Fluency -- 3.3.2 Motor Function -- Motor Speed -- Motor Coordination and Postural Balance -- Tremor -- Bradykinesia -- Hand Dexterity -- 3.3.3 Olfactory Function -- 3.3.4 Emotional Function and Mood -- 4 Discussion and Recommendations -- 5 Conclusions -- References -- Photodegradation of Pharmaceutical and Personal Care Products (PPCPs) and Antibacterial Activity in Water by Transition Metals -- 1 Introduction -- 2 Transition Metals -- 3 Pharmaceutical and Personal Care Products (PPCPs) -- 4 Global Production of Drinking Water -- 5 Photocatalysis -- 6 Mechanism of Photocatalysis -- 7 Treatment of PPCPs in Wastewater by Transition Metal-Modified Magnetite Photocatalysis -- 8 Visible Light-Responsive Nano-based Transition Metal Photocatalysts in Antibacterial Activity -- 9 Comparison Between Photocatalysts, Antibiotics, and PPCPs -- 10 Application of Transition Metals in Photocatalysis -- 11 Future Perspectives and Conclusion -- References -- Effects of Carbamazepine in Bivalves: A Review -- 1 Introduction -- 2 Marine Bivalves Exposed to Carbamazepine Under Laboratory Conditions: Toxicological Effects -- 2.1 Mussels -- 2.1.1 CBZ Effects on Physiological Processes -- 2.1.2 CBZ Effects on the Biotransformation and Detoxification Processes -- 2.1.3 CBZ Effects on Oxidative Stress-Related Parameters -- 2.1.4 CBZ Effects on Multiple General Stress Responses -- 2.1.5 CBZ Effects on the Mode of Action-Related Processes and Metabolic Pathways -- 2.2 Clams -- 2.2.1 CBZ Effects on Physiological Processes -- 2.2.2 CBZ Effects on the Biotransformation and Detoxification Processes -- 2.2.3 CBZ Effects on Oxidative Stress-Related Parameters -- 2.2.4 CBZ Effects on the Mode of Action-Related Processes -- 2.3 Oysters. , 3 Conclusions and Future Perspectives -- References -- Fine Particulate Matter (PM2.5) and Chronic Kidney Disease -- 1 Introduction -- 2 Method -- 3 The Compositions of PM2.5 -- 4 PM2.5 and CKD: Epidemiological Studies -- 5 PM2.5 and CKD: Progression and Prevention -- 6 PM2.5 and CKD: Mechanisms -- 7 Global Implication of Polices and Measurements -- 8 Conclusions -- References -- Correction to: Occurrence of Levonorgestrel in Water Systems and Its Effects on Aquatic Organisms: A Review.

Anmerkung: Intro -- Foreword -- Preface -- Contents -- List of Contributors -- Metalliferous Mining Pollution and Its Impact on Terrestrial and Semi-terrestrial Vertebrates: A Review -- 1 Introduction -- 2 Methodology -- 3 Results and Discussion -- 3.1 Geographical and Temporary Distribution and Operational Status -- 3.2 Main Metal Ore -- 3.3 Sentinel Species -- 3.4 Biomarkers -- 3.4.1 Biomarkers of Exposure -- 3.4.2 Biomarkers of Effect -- Biochemical and Hematological Biomarkers -- Genotoxic Parameters -- Health Status at Individual Level -- Population and Community Level Biomarkers -- 4 Conclusions -- References -- Fluorotelomer Alcohols´ Toxicology Correlates with Oxidative Stress and Metabolism -- 1 Introduction -- 2 Metabolism of FTOHs -- 2.1 Metabolic Pathways and Toxicokinetics -- 2.2 Metabolising Enzymes -- 3 Toxicity -- 4 Toxicity Induced by Oxidative Stress -- 4.1 Generation of Oxidative Stress and ROS -- 4.2 Oxidative Damage -- 4.2.1 Damage to DNA -- 4.2.2 Damage to Lipids -- 4.3 Alterations in Antioxidant Status -- 4.4 Cell Signalling -- 5 Conclusion and Prospects -- References -- Perchlorate Contamination: Sources, Effects, and Technologies for Remediation -- 1 Introduction -- 2 Origins and Utilisation of Perchlorate -- 2.1 Natural Origin -- 2.2 Anthropogenic Origin -- 3 Environmental and Health Effects -- 3.1 Health Effects on Humans -- 3.2 Effects on Biota -- 4 Technologies for Perchlorate Treatment -- 4.1 Physicochemical Methods -- 4.1.1 Membrane-Based Technologies -- 4.1.2 Ion Exchange -- 4.1.3 Chemical Reduction -- 4.1.4 Electrochemical Reduction -- 4.1.5 Activated Carbon -- 4.2 Biological Treatment of Perchlorate -- 4.2.1 Types of Perchlorate-Reducing Bacteria -- 4.2.2 Habitats of Perchlorate-Reducing Bacteria -- 4.2.3 Environmental Requirements for Bacterial Degradation of Perchlorate. , 4.2.4 Biochemical Metabolism of Perchlorate-Reducing Bacteria -- 4.2.5 Application of Biological Reduction -- 5 Conclusions -- References -- Sources of Antibiotic Resistant Bacteria (ARB) and Antibiotic Resistance Genes (ARGs) in the Soil: A Review of the Spreading M... -- 1 Introduction -- 2 ARGs in the Soil Environment -- 3 Sources of ARGs in the Soil Environment -- 3.1 ARB and ARGs in Soils Due to Manure Application -- 3.2 Different Types of Manure Sources Influence ARGs Occurrence in the Soil -- 3.3 Wastewater as a Source of ARB and ARGs in the Soil -- 3.3.1 Release of ARB and ARGs from WWTP Effluents into the Soil -- 3.3.2 Impacts of Irrigation Using WWTP Effluents on the Abundance of ARB and ARGs in the Soil -- 3.3.3 Persistence of ARGs in WWTP Effluents as a Source of ARB and ARGs Dissemination in the Soil -- 3.3.4 Application of Sewage Sludge to Agricultural Soils -- 3.3.5 Deposition of ARGs from Livestock Excrements into the Soil Environment -- 3.3.6 ARGs in Native Soils -- 4 Dissemination of Associated-ARGs with Anthropogenically Impacted Environments into the Soil -- 4.1 Human Exposure Risk Related to Runoff and Leaching -- 4.2 Human Risk Exposure Pathways Due to Plants Uptake -- 4.3 Human Exposure Pathways Due to Groundwater Contaminated with Antibiotics and Their Related ARB and ARGs -- 5 Sorption of Antibiotics in Soil: ARB and ARGs Dissemination -- 5.1 Transfer of Antibiotics Resistance Genes in Agroecosystem -- 5.2 ARB and ARGs Associated Genes in Livestock Production Farms -- 6 Environmental and Ecological Effects of Soil Antibiotics and Related ARB and ARGs -- 7 Health Effects of Soil Contaminated Antibiotics and Their Related ARB and ARGs -- 7.1 Impact of Antibiotic Resistance on Human and Environmental Health -- 7.2 Ecological Health Risk Related to the Antibiotics and the Antibiotic Resistance. , 8 Suggestions and Mitigation Strategies -- 9 Conclusion -- References -- An Overview of Morpho-Physiological, Biochemical, and Molecular Responses of Sorghum Towards Heavy Metal Stress -- 1 Introduction -- 2 Heavy Metal Uptake, Translocation, and Accumulation in Sorghum -- 3 Impact of Heavy Metals on the Morphological Characteristics of Sorghum -- 4 Effect of Heavy Metals on the Physiological Aspects of Sorghum -- 5 Biochemical Changes in Response to Heavy Metals in Sorghum -- 6 Molecular Modulations Under Heavy Metal Stress in Sorghum -- 7 Future Prospects -- 8 Conclusion -- References -- Water and Soil Pollution: Ecological Environmental Study Methodologies Useful for Public Health Projects. A Literature Review -- 1 Introduction -- 2 Methods -- 3 Results -- 3.1 Type 1: Regression with Data by Geographical Area -- 3.2 Type 2: Regression Models at Individual Level -- 3.3 Type 3: Exposure Intensity Threshold Values for Evaluating Health Outcome -- 3.4 Type 4: Distance between Pollutant Source and Health Outcome Clusters -- 4 Discussion -- 5 Conclusion -- References.

Anmerkung: Intro -- Foreword -- Preface -- Contents -- List of Contributors -- Review on Health Impacts from Domestic Coal Burning: Emphasis on Endemic Fluorosis in Guizhou Province, Southwest China -- 1 Introduction -- 2 Endemic Fluorosis in Guizhou Province -- 2.1 Origin of the Health Issue -- 2.2 Epidemiological Data -- 2.3 Possible Exposure Routes -- 2.3.1 Drinking Water -- 2.3.2 Foodstuffs -- 2.3.3 Other Exposure Routes -- 2.4 Possible Sources of Fluorine -- 2.4.1 Fluorine in Soil -- 2.4.2 Fluorine in Coal -- 2.4.3 Fluorine in Clay -- 2.5 Real Culprit of the Endemic Fluorosis in Guizhou Province -- 2.6 Control of the Endemic Fluorosis in Guizhou Province -- 3 Other Health Problems -- 4 Conclusion -- References -- Dissipation, Fate, and Toxicity of Crop Protection Chemical Safeners in Aquatic Environments -- 1 Introduction -- 2 Methods -- 3 Leaching -- 4 Sorption -- 5 Volatilization -- 6 Photolysis -- 7 Chemical Reduction and Nucleophilic Substitution -- 8 Biological Degradation -- 9 Toxicity -- 10 Conclusion -- 11 Methods for Laboratory Studies -- References -- Do Endemic Soil Fauna Species Deserve Extra Protection for Adverse Heavy Metal Conditions? -- 1 Introduction -- 2 The Various Forms and Descriptions of Endemism -- 3 Where Are Endemic Species Found and Do They Occur in Metalliferous Areas? -- 4 Do Endemic Species Show a Higher or Lower Sensitivity for Adverse Environmental Factors? -- 5 Extra Protection for Endemic Species by Adapted Risk Assessment Procedures -- 6 Further Actions -- References -- Aflatoxin M1 in Africa: Exposure Assessment, Regulations, and Prevention Strategies - A Review -- 1 Introduction -- 2 Toxic Effects of AFM1 -- 3 AFM1 in Milk and Dairy Products -- 3.1 North Africa -- 3.2 East Africa -- 3.3 West Africa -- 3.4 Central Africa -- 3.5 Southern Africa -- 4 AFM1 in Human Biological Fluids: Breast Milk, Serum, and Urine. , 4.1 North Africa -- 4.2 Eastern Africa -- 4.3 West Africa -- 4.4 Central Africa -- 4.5 Southern Africa -- 5 Exposure Level Estimates in Africa -- 5.1 Exposure Through Milk Intake -- 5.2 Exposure Through Breast Milk and Urine Bio-Monitoring -- 6 Detoxification Strategies of AFM1 -- 7 AFM1 Regulations in Africa -- 8 Conclusion and Recommendations -- References -- In Vivo and In Vitro Toxicity Testing of Cyanobacterial Toxins: A Mini-Review -- 1 Introduction -- 2 Radionuclide Recovery In Vivo -- 2.1 Toxicity of Microcystin-LR In Vivo -- 2.2 Toxicity of Cylindrospermopsins In Vivo -- 3 Immunochemistry -- 3.1 Toxicity of Microcystin In Vivo -- 3.2 Toxicity of Cylindrospermopsins In Vivo -- 4 Daphnia Magna Test -- 4.1 Toxicity of Microcystin In Vivo -- 4.2 Toxicity of Anatoxin-a In Vivo -- 5 Artemia Salina Assay -- 5.1 Toxicity of Cylindrospermopsins In Vivo -- 5.2 Toxicity of Anatoxin-a In Vivo -- 5.3 Toxicity of Microcystin In Vivo -- 5.4 Toxicity of Saxitoxin In Vivo -- 6 Micronucleus Assay -- 6.1 Toxicity of Microcystin-LR In Vivo -- 6.2 Toxicity of Cylindrospermopsins In Vitro -- 6.3 Toxicity of Nodularin In Vivo -- 7 Cytotoxicity (Neutral Red) Assay -- 7.1 Toxicity of Microcystin In Vitro -- 7.2 Toxicity Detection of Cylindrospermopsins In Vivo and In Vitro -- 8 Comet Assay -- 8.1 Toxicity of Microcystin In Vivo -- 8.2 Toxicity of Cylindrospermopsins In Vitro and In Vivo -- 9 Annexin V-FITC Assay (Fluorescein Isothiocyanate Labeled Annexin V) -- 9.1 Toxicity of Cylindrospermopsins In Vitro -- 9.2 Toxicity of Microcystin and Anatoxin-a In Vitro -- 9.3 Toxicity of Nodularin In Vitro -- 10 MTT Assay -- 10.1 Toxicity of Cylindrospermopsins In Vivo -- 10.2 Toxicity of Cylindrospermopsins, Microcystins, and Anatoxin-a In Vitro -- 10.3 Toxicity of Microcystin-LR In Vitro -- 11 Enzyme-Linked Immunosorbent Assay (ELISA). , 11.1 Toxicity of Microcystins and Nodularin In Vivo and In Vitro -- 11.2 Toxicity of Saxitoxins In Vitro -- 12 Protein Phosphatase Inhibition Assay (PPIA) -- 12.1 Identification of Microcystins and Nodularins Through PPIA In Vitro Assays -- 13 Conclusion -- References -- Comprehensive Review of Cadmium Toxicity Mechanisms in Male Reproduction and Therapeutic Strategies -- 1 Introduction -- 2 Cd Toxicity on Male Reproduction -- 2.1 Animal Experiments -- 2.2 Clinical or Epidemiological Studies -- 2.3 Relevance of Studies in Animals to Human Exposure and Potential Risks -- 3 Cd Toxicity on Offspring -- 4 Mechanism of Cd Damage on Male Reproductive System -- 4.1 Activation of Oxidative Stress -- 4.2 Induction of Gonad Inflammation -- 4.3 Impairment of Endocrine System -- 4.4 Competition with Essential Trace Elements -- 4.5 Changes in Epigenetics -- 5 Potential Therapeutic Strategies -- 5.1 Inhibition of Oxidative Stress -- 5.2 Anti-Gonad Inflammation -- 5.3 Recovery of Endocrine System -- 5.4 Supplementation with Essential Trace Elements -- 6 Conclusion and Recommendations -- References -- Micronuclei in Fish Erythrocytes as Genotoxic Biomarkers of Water Pollution: An Overview -- 1 Introduction -- 2 Micronucleus Test -- 3 Fish Species -- 4 Experimental Conditions -- 4.1 Catching of Wild Fish in Polluted Waters -- 4.2 In Situ Exposure of Caged Fish in Polluted Waters -- 4.3 Laboratory Exposure of Fish to Sampled Polluted Waters -- 5 Results of the Studies -- 6 Conclusions -- References.

Anmerkung: Intro -- Foreword -- Preface -- Contents -- List of Contributors -- Microplastics in the Food Chain: Food Safety and Environmental Aspects -- 1 Introduction -- 2 Plastic Material -- 2.1 Top 5 Plastics Found in Waste -- 2.1.1 Low Density Polyethylene (LDPE) -- 2.1.2 Polypropylene (PP) -- 2.1.3 Polyphthalamide (PPA) -- 2.1.4 High-Density Polyethylene (HDPE) -- 2.1.5 Polyethylene (PE) -- 3 Degradation of Plastic Polymers -- 3.1 Biodegradable Plastic -- 4 Plastic Waste Disposal -- 4.1 Burying in Landfill -- 4.2 Incineration -- 4.3 Recycling -- 5 EU Legislation Regarding Plastic Waste -- 5.1 Circular Economy Action Plan -- 5.1.1 Make Recycling Profitable for Business -- 5.1.2 Curb Plastic Waste -- 5.1.3 Stop Littering at Sea -- 5.1.4 Drive Investment and Innovation -- 5.1.5 Spur Change Across the World -- 6 Environmental Aspects -- 6.1 Terrestrial Ecosystem -- 6.2 Marine Ecosystem -- 6.3 Freshwater Ecosystem -- 6.4 Microplastics in Aquatic Organisms of Commercial Interest -- 7 Food Safety Aspects -- 7.1 Adverse Effects -- 7.2 Potential Effects on Humans -- 8 Conclusions -- References -- Toxicity of Graphene: An Update -- 1 Introduction -- 2 Physiochemical Properties Determine the Fate and the Toxicity of Graphene -- 3 In Vitro Toxicity -- 4 In Vivo Toxicity -- 5 Simulation Studies on Graphene Toxicity -- 6 Environmental Toxicity -- 7 Toxicity Is Beneficial in the Context of Cancer and Microbiology! -- 8 How to Reduce the Toxicity? -- 9 Conclusion -- References -- Multi-Level Gene Expression in Response to Environmental Stress in Aquatic Invertebrate Chironomids: Potential Applications in... -- 1 Introduction -- 2 Chironomids as Bioindicator Species in Aquatic Ecosystem -- 3 Molecular Genetic Research on Environmental Stress in Chironomids -- 3.1 Gene Responses to Physical Stressors in Chironomids -- 3.1.1 Heat Shock -- 3.1.2 Temperature. , 3.2 Gene Responses to Chemical Stressors in Chironomids -- 3.2.1 UV Filters -- 3.2.2 Heavy Metals -- 3.2.3 Nanoparticles -- 3.2.4 Endocrine Disruptor Chemicals (EDCs) -- 3.2.5 Insecticides -- 3.2.6 Antibiotics -- 3.2.7 Herbicides -- 3.2.8 Fungicides and Biocides -- 3.2.9 Carcinogenic Substances and Synthetic Estrogen -- 3.2.10 Mixture and Field Exposure -- 4 Discussion -- 5 Conclusion -- References -- Role of Structural Morphology of Commodity Polymers in Microplastics and Nanoplastics Formation: Fragmentation, Effects and As... -- 1 Introduction -- 1.1 Plastics, Microplastics and Nanoplastics -- 2 Sources and Behaviour -- 2.1 Properties of Commodity Polymers -- 2.2 Mechanical Properties -- 3 Fragmentation Pathways -- 4 Common Commercial Plastics and Their MP/NP Derivatives -- 4.1 Thermoplastics -- 4.1.1 Polyethylene -- 4.1.2 Polypropylene -- 4.1.3 Polystyrene -- 4.1.4 Polyvinyl Chloride -- 4.1.5 Polyethylene Terephthalate -- 4.2 Thermosets -- 4.2.1 Polyurethane -- 4.2.2 Epoxy Resins -- 4.2.3 Poly(Styrene-Co-Divinylbenzene) -- 4.2.4 Styrene-Butadiene Rubber -- 5 Toxicity of Commodity Polymer MPs and NPs -- 5.1 Thermoplastics -- 5.1.1 Polyethylene -- 5.1.2 Polypropylene -- 5.1.3 Polystyrene -- 5.1.4 Polyvinyl Chloride -- 5.1.5 Polyethylene Terephthalate -- 5.2 Thermosets -- 5.2.1 Polyurethanes -- 5.2.2 Epoxy Resins -- 5.2.3 Poly(Styrene-Co-Divinylbenzene) -- 5.2.4 Styrene-Butadiene Rubber -- 5.2.5 Interactions with Other Contaminants -- 6 Detection -- 7 Regulations and International Initiatives -- 8 Conclusions -- References -- Prioritization of Pesticides for Assessment of Risk to Aquatic Ecosystems in Canada and Identification of Knowledge Gaps -- 1 Introduction -- 2 Methods -- 2.1 Scope of the Review -- 2.2 Identification of Pesticides of Top Concern for Aquatic Biota -- 3 Pesticides in the Canadian Aquatic Environment. , 3.1 National Results and Regional Contexts -- 3.2 Top-Priority Active Ingredients -- 3.3 Review of Top-Priority Active Ingredients -- 3.3.1 Herbicides -- Atrazine -- Presence in the Aquatic Environment -- Toxicity Towards Aquatic Organisms -- Exposure Risks for Aquatic Organisms -- Diquat -- Presence in the Aquatic Environment -- Toxicity Towards Aquatic Organisms -- Exposure Risks for Aquatic Organisms -- S-Metolachlor -- Presence in the Aquatic Environment -- Toxicity Towards Aquatic Organisms -- Exposure Risks for Aquatic Organisms -- 3.3.2 Insecticides -- Chlorpyrifos -- Presence in the Aquatic Environment -- Toxicity Towards Aquatic Organisms -- Exposure Risks for Aquatic Organisms -- Clothianidin -- Presence in the Aquatic Environment -- Toxicity Towards Aquatic Organisms -- Exposure Risks for Aquatic Organisms -- Permethrin -- Presence in the Aquatic Environment -- Toxicity Towards Aquatic Organisms -- Exposure Risks for Aquatic Organisms -- 3.3.3 Fungicides -- Chlorothalonil -- Presence in the Aquatic Environment -- Toxicity Towards Aquatic Organisms -- Exposure Risks for Aquatic Organisms -- 4 General Knowledge Gaps and Recommendations -- 4.1 Baseline Fish and Fish Habitat Data -- 4.2 Pesticide Monitoring Data -- 4.3 Marine and Sediment Benchmarks -- 4.4 Mixture Toxicity -- 4.5 Study Design and Analytical Methods for Compounds with Low Benchmarks -- 4.6 Habitat and Food Web-Mediated Effects on Fish -- 4.7 Current-Use and Legacy Pesticides in the Arctic -- 5 Conclusions -- References -- Correction to: Prioritization of Pesticides for Assessment of Risk to Aquatic Ecosystems in Canada and Identification of Knowl.