Publikationsdatum:
2018-06-29
Beschreibung:
Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice, Published online: 28 June 2018; doi:10.1038/s41467-018-04982-3 The valine-citrulline dipeptide, which is used as a cleavable linker for antibody-drug conjugates, is instable in mouse plasma. Here, the authors developed a glutamic acid–valine–citrulline tripeptide sequence as a stable alternative that still is susceptible to cathepsin-mediated cleavage.
Digitale ISSN:
2041-1723
Thema:
Biologie
,
Chemie und Pharmazie
,
Allgemeine Naturwissenschaft
,
Physik
Permalink