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  • 1
    Online-Ressource
    Online-Ressource
    Singapore :Springer Singapore Pte. Limited,
    Schlagwort(e): Science-Congresses. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (425 pages)
    Ausgabe: 1st ed.
    ISBN: 9789813298286
    DDC: 500
    Sprache: Englisch
    Anmerkung: Intro -- Organizing Committee -- General Chair -- General Co-Chair -- Technical Program Chair -- Technical Program Co-Chair -- Finance Chair -- Publicity Chair -- Local Arrangements Chair -- Sponsorship Chair -- Publication Chair -- International Advisory Panel Chair -- International Advisory Panel -- TPC Members -- Preface -- Acknowledgements -- Contents -- Prognostic Biomarkers for Hepatocellular Carcinoma -- 1 Background and Purpose of Research -- 2 Hypothesis -- 3 Materials and Methods -- 3.1 Study Population -- 3.2 RNA Extraction from FFPE Tissue -- 3.3 Design of qPCR Assay for FFPE Tissue RNA -- 3.4 Processing of qPCR Expression Data -- 3.5 Statistical Analysis -- 4 Results and Discussion -- 4.1 Clinical Application -- 4.2 Cellular Functions of Prognostic Genes -- 4.3 Limitations -- 5 Conclusion and Recommendation for Future Work -- References -- Green Synthesis of Nanoparticles Using Dried Fruit Peel Extract -- 1 Introduction -- 2 Materials and Methods -- 3 Results and Discussion -- 4 Conclusion -- References -- Optimization of the Electrospinning Process to Create Pure Gelatin Methacrylate Microstructures for Tissue Engineering Applications -- 1 Introduction -- 2 Aims and Objectives -- 3 Methods and Materials -- 4 Results and Discussion -- 5 Conclusion and Recommendations for Future Work -- Appendix -- References -- Study of Bird Feathers to Improve Design of Absorbent Pads for Greater Efficiency of Oil Spill Removal -- 1 Introduction -- 2 Hypothesis -- 3 Methodology -- 3.1 Comparison of Oil Adsorption Ability of Feathers and Regular Paper Towels -- 3.2 Effect of Surface Area to Mass Ratio on Oil Absorption Ability of Absorbent Pads -- 3.3 Comparison of Oil Adsorbency of Materials -- 4 Results and Discussion -- 5 Conclusion and Future Works -- Appendix -- References. , Design of Smart Antimicrobial Materials Based on Silver-Silica Nanocapsules -- 1 Background and Purpose of Research Area -- 2 Engineering Goal of Project -- 3 Methods and Materials -- 3.1 Synthesis of Silica Nanocapsules -- 3.2 Synthesis of Silver Nanocapsules (AgNCs) -- 3.3 Characterization Methods -- 3.4 Preliminary Processing of Composite Antimicrobial Biomaterial Using PVA Film -- 3.5 Preliminary Processing of Composite Antimicrobial Biomaterial Using F127 Hydrogel -- 4 Results and Discussion -- 4.1 Silica Nanocapsules Templates -- 4.2 Optimization of the Synthesis Conditions of AgNCs -- 4.3 Properties of AgNCs -- 4.4 Incorporation of AgNCs into PVA Film to Form Composite Biomaterial -- 4.5 Incorporation of AgNCs into F127 Hydrogel to Form Composite Biomaterial -- 5 Results and Discussion -- Appendices -- Appendix 1: Synthesis of Silica Nanocapsules -- Appendix 2: Variation of Reaction Conditions to Synthesize AgNCs -- Appendix 3: Response of AgNCs to Acidic Conditions -- Appendix 4: Incorporation of AgNCs into PVA Film to Form Composite Material -- Appendix 5: Sol-to-Gel Transition of F127 Hydrogel at Different wt% -- References -- Investigation of Low Cost Eye Tracker and EEG for Objectively Assessing Vigilance Level -- 1 Background and Purpose of Research -- 2 Objective and Hypothesis -- 3 Experiment Design and Data Collection -- 3.1 Experimental Design for Sensor Evaluation -- 3.2 Experimental Design for Vigilance Testing -- 4 Data Analysis and Evaluation -- 5 Discussion -- 6 Conclusion -- References -- Human Attribute Classification for Re-identification Across Non-overlapping Cameras -- 1 Introduction -- 2 Hypothesis -- 3 Methods and Materials -- 3.1 Inception V3 -- 3.2 Person Re-ID Base-Net -- 3.3 Evaluation Methods -- 4 Results and Discussion -- 5 Conclusion and Future Work. , Appendix: Code to Calculate Precision and Recall of Each Attribute -- References -- The Power of the Micro-tide -- 1 Literature Review and Background -- 2 Hypothesis -- 3 Methodology -- 4 Results and Discussion -- 5 Conclusion and Further Advancements -- Appendix -- References -- The Application of Markov Chains in Multiplayer Online Battle Arena (MOBA) Games -- 1 Introduction and Purpose -- 2 Hypothesis -- 3 Methodology -- 3.1 Derivation of Model -- 3.2 Experiment -- 4 Results -- 5 Discussion and Conclusion -- References -- Investigating the Air Quality in Bus Stops Using IoT-Enabled Devices -- 1 Introduction -- 2 Hypothesis -- 3 Methods and Materials -- 3.1 Mobile AirQ and Smartphone App -- 4 Results and Discussion -- 4.1 Position within Bus Stop -- 4.2 Frequency of Buses Arriving -- 4.3 Vehicular Traffic -- 5 Conclusion -- References -- Novel Method to Reconstruct a Surface Grid Using Linear Regression Modelling -- 1 Introduction -- 2 Engineering Goal -- 3 Methodology and Materials -- 3.1 Image Analysis -- 3.2 Geometric Relations (GR) Method -- 3.3 Linear Regression Models (LRMs) Method -- 3.4 Initialising Linear Regression Models (LRMs) -- 3.5 Training Linear Regression Models (LRMs) -- 3.6 Translation and Rotation of Points -- 4 Results and Discussion -- 5 Conclusions and Recommendations for Future Work -- Appendix: Similar triangle -- References -- Demonstration of Switching Plasmonic Chirality via Geometric Transformations for Biosensing Applications -- 1 Introduction -- 2 Methods -- 3 Results and Discussion -- 4 Conclusion -- References -- Microbial Fuel Cells: Food Waste as a Sugar Source -- 1 Introduction -- 1.1 Background of Research -- 1.2 Objective -- 1.3 Hypothesis -- 2 Methodology -- 2.1 Preparation of Food Waste Substrates -- 2.2 Assembling of Microbial Fuel Cells -- 2.3 Testing of Microbial Fuel Cells -- 2.4 Food Tests. , 3 Results and Discussion -- 3.1 Microbial Fuel Cell Setups Results -- 3.2 Food Test Results -- 3.3 Discussion -- 4 Conclusion -- 5 Future Work -- References -- Cross-Talk Between Cell Mechanics and Biochemical Signalling Pathways via Modulation of Nucleocytoplasmic Shuttling of Transcription Factors: A Novel Approach to Study Fibroblasts in Breast Cancer Environments -- 1 Introduction -- 2 Methods and Materials -- 2.1 Cell Culture and Treatment -- 2.2 Engineering Cells in 3D Collagen Matrix -- 2.3 Micropatterning -- 2.4 Fluorescent Staining on 3D Matrix -- 2.5 Fluorescent Staining on 2D Micro-Patterned Substrates -- 2.6 Imaging, Digital Image Analysis and Statistical Analysis -- 3 Results and Discussion -- 3.1 Cellular Mechanics Impinge on Nuclear Morphology -- 3.2 Cellular Mechanics Modulate Cellular Response to TNF-Alpha Stimulation -- 3.3 Cellular Mechanics Modulate Cellular Response to Stimulation with MCF-7 Conditioned Media -- 3.4 Cellular Mechanics Modulate Vimentin Protein Levels -- 4 Conclusion and Future Work -- Appendices -- Micro-patterned Fibronectin -- NIH3T3 Embryonic Mouse Fibroblasts on Patterns -- References -- A Study of Chitosan Films as a Feasible Material for Wound Dressing -- 1 Introduction -- 2 Materials and Methods -- 2.1 Synthesis of Chitosan Film -- 2.2 Modifications Made to Standard Film -- 2.3 Incorporation of Other Chemicals -- 3 Testing of Synthesised Material -- 3.1 Tensile Strength Test -- 3.2 Antibacterial Property Test -- 3.3 Air Permeability Test -- 3.4 Effects of Water on Film -- 4 Experimental Data and Analysis -- 4.1 Tensile Strength Test -- 4.2 Antibacterial Property Test -- 4.3 Air Permeability Test -- 4.4 Effects of Water on Film -- 5 Conclusion -- 6 Limitations -- 7 Future Research -- References -- Demonstration Kit for Battery-Less RF Energy Harvesting Device -- 1 Introduction -- 2 System Setup. , 2.1 Receiving Antenna -- 2.2 Rectifier Circuit -- 2.3 Power Management Circuit -- 2.4 Sensor Tag -- 3 Development of Rectenna -- 4 Development of Sensor Tag -- 5 Development of Power Management Circuit -- 5.1 Configuration of Jumpers -- 5.2 Configuration of User Programmable Values -- 5.3 Selecting a Storage Element -- 5.4 Optimising the Power Management Circuit -- 6 Demonstration Kit Assembly and Testing -- 7 Conclusion -- 8 Future Work -- References -- A Novel Approach to Desalination Using Modified Bio-wastes as Adsorbents -- 1 Introduction -- 1.1 Background -- 1.2 Objective -- 1.3 Scope of Work -- 2 Methodology -- 2.1 Bleaching Banana Stem Waste -- 2.2 Dialysis of Polymers -- 2.3 Synthesis of Hydrogels -- 2.4 Batch Adsorption Studies -- 3 Results and Discussion -- 3.1 Characterization -- 3.2 Batch Adsorption Studies -- 4 Conclusion -- 5 Future Work -- References -- Dye-Sensitised Solar Cells Using Flora Extracts -- 1 Introduction -- 2 Methods -- 2.1 Dye Extraction -- 2.2 Preparation of TiO2 Paste -- 2.3 Preparation of Carbon Coated Glass Plates -- 2.4 Preparation of 1% Agarose Gel with 4% NaCl -- 2.5 Assembly of Dye-Sensitised Solar Cells -- 2.6 Test for Voltage -- 3 Results and Discussion -- 3.1 Analysis of Experimental Results -- 3.2 Spectrum Graph Analysis -- 4 Conclusion -- 5 Future Work -- References -- Genes Associated with Disease-Free Survival Prognosis of Renal Cancers -- 1 Introduction -- 2 Methodology -- 2.1 Overview -- 2.2 Selecting Differentially Expressed Genes from the Cancer Genome Atlas -- 2.3 Kaplan-Meier Plots -- 2.4 Log-Rank Test and Hazard Ratio -- 2.5 Criterion for Kaplan-Meier Plots -- 2.6 Database for Annotation, Visualisation and Integrated Discovery (DAVID) v6.8 -- 3 Results and Discussion -- 3.1 Overview -- 3.2 Kidney Chromophobe -- 3.3 Kidney Renal Clear Cell Carcinoma -- 3.4 Kidney Renal Papillary Cell Carcinoma. , 3.5 Bladder Urothelial Carcinoma.
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  • 2
    Schlagwort(e): Biomedical Engineering/Biotechnology ; Biomedical engineering ; Biomaterials ; Energy systems ; Physics ; Engineering—Materials
    Beschreibung / Inhaltsverzeichnis: Green Synthesis of Nanoparticles Using Dried Fruit Peel Extract -- Enhancing and Determining the rate of polystyrene composting process through the use of Mealworms -- Nutrients for the Elderly -- Novel Encapsulation of Cadmium Orthostannate Nanoparticles with 3-(mercaptopropyl) trimethoxysilane: Synthesis, Characterisation, and Application -- Enhancing Children’s Concentrating Abilities Through A Laser Firing Game Approach -- Investigating the Effectiveness of Wind Tunneling at Reducing the Urban Heat Island Effect -- Colloidal Flows Through Polymer Brush-Coated Nanochannel -- Application of Artificial Neural Networks on UAV Airfoil Performance Prediction -- Study of Bird Feathers to Improve Design of Absorbent Pads for Greater Efficiency of Oil Spill Removal -- Identifying Phishing Sites through the Inspection of SSL Certificates
    Materialart: Online-Ressource
    Seiten: 1 Online-Ressource (XV, 427 p)
    Ausgabe: 1st ed. 2019
    ISBN: 9789813298286
    Serie: Springer eBooks
    Sprache: Englisch
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  • 3
    Online-Ressource
    Online-Ressource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    Schlagwort(e): Environment. ; Agriculture. ; Soil science.
    Beschreibung / Inhaltsverzeichnis: Part 1: Climate Change and Global Food Security -- Chapter 1: Climate Change and Global Food Security -- Chapter 2: A Perspective Way to Climate Smart Agriculture -- Chapter 3: An Insight on Different Climate Smart and Resilient Agricultural Practices -- Chapter 4: Soil Management in Sustainable Agriculture: Principles and Techniques -- Chapter 5: Dynamics of Nutrients, Soil Organic Carbon and Smart Nutrient Management Practices.-Chapter 6: Impact on Agricultural Crop Production under Climate Change Scenario -- Chapter 7: Metal (loid) Source and Effects on Peri Urban Agriculture/aquaculture sediments -- Chapter 8: Monitoring and Forecasting Land Use and Land Cover Changes in Paddy Cultivation -- Chapter 9: A bioinformatics insight on agriculture -- Part 2: Advanced technology in agriculture for climate smart faming -- Chapter 10: Advanced technology in agriculture for climate smart faming -- Chapter 11: Adaptation and Mitigation Strategies under Climate Change Scenario -- Chapter 12: Precision Farming: A Step Towards Sustainable, Climate-Smart Agriculture -- Chapter 13: Geospatial Technology for Climate Change: Influence of ENSO and IOD -- Chapter 14: Simulation Modelling for Climate Smart Agriculture -- Chapter 15: Strategic Intervention for Climate-Smart Agriculture -- Chapter 16: Climate Policies for Climate Smart Approach -- Chapter 17: Land Use Change and Agro-Climatic Interactions -- Chapter 18: Drone Technology in Perspective of Data Capturing -- Chapter 19: Renovating Conservation Agriculture: Management and Future Prospects.
    Materialart: Online-Ressource
    Seiten: 1 Online-Ressource(XVI, 411 p. 101 illus., 99 illus. in color.)
    Ausgabe: 1st ed. 2024.
    ISBN: 9783031527081
    Sprache: Englisch
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  • 4
    Publikationsdatum: 2016-02-06
    Beschreibung: We examine the spatio-temporal variability of aerosol loading in the recent decade (2005–2014) over the North American Monsoon (NAM) region. Emerging patterns are characterized using aerosol optical depth (AOD) retrievals from the NASA Terra/Moderate Resolution Imaging Spectroradiometer (MODIS) instrument along with a suite of satellite retrievals of atmospheric and land-surface properties. We selected 20 aerosol hotspots and classified them into fire, anthropogenic, dust, and NAM alley clusters based on the dominant driver influencing aerosol variability. We then analyzed multivariate statistics of associated anomalies during pre-, monsoon, and post-monsoon periods. Our results show a decrease in aerosol loading for the entire NAM region, confirming previous reports of a declining AOD trend over the continental United States. This is evident during pre-monsoon and monsoon for fire and anthropogenic clusters, which are associated with a decrease in the lower and upper quartile of fire counts and carbon monoxide, respectively. The overall pattern is obfuscated in the NAM alley, especially during monsoon and post-monsoon seasons. While the NAM alley is mostly affected by monsoon precipitation, the frequent occurrence of dust storms in the area modulates this trend. We find that aerosol loading in the dust cluster is associated with observed vegetation index and has only slightly decreased in the recent decade.
    Digitale ISSN: 2073-4433
    Thema: Geologie und Paläontologie
    Publiziert von MDPI Publishing
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  • 5
    Publikationsdatum: 2016-02-14
    Beschreibung: Article SIRT7 is a protein deacetylase with important roles in rRNA synthesis, ribosome biogenesis and cell proliferation. Here the authors show a role of SIRT7 in rRNA maturation via deacetylation of U3-55k, a core component of the U3 snoRNP complex. Nature Communications doi: 10.1038/ncomms10734 Authors: Sifan Chen, Maximilian Felix Blank, Aishwarya Iyer, Bingding Huang, Lin Wang, Ingrid Grummt, Renate Voit
    Digitale ISSN: 2041-1723
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik
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  • 6
    Publikationsdatum: 2016-02-16
    Beschreibung: Indole-3-carbinol (I3C), an anti-cancer phytochemical derived from cruciferous vegetables, strongly inhibited proliferation and down-regulated protein levels of the melanocyte master regulator micropthalmia-associated transcription factor (MITF-M) in oncogenic BRAF-V600E expressing melanoma cells in culture as well as in vivo in tumor xenografted athymic nude mice. In contrast, wild type BRAF-expressing melanoma cells remained relatively insensitive to I3C anti-proliferative signaling. In BRAF-V600E-expressing melanoma cells, I3C treatment inhibited phosphorylation of MEK and ERK/MAPK, the down stream effectors of BRAF. The I3C anti-proliferative arrest was concomitant with the down-regulation of MITF-M transcripts and promoter activity, loss of endogenous BRN-2 binding to the MITF-M promoter, and was strongly attenuated by expression of exogenous MITF-M. Importantly, in vitro kinase assays using immunoprecipitated BRAF-V600E and wild type BRAF demonstrated that I3C selectively inhibited the enzymatic activity of the oncogenic BRAF-V600E but not of the wild type protein. In silico modeling predicted an I3C interaction site in the BRAF-V600E protomer distinct from where the clinically used BRAF-V600E inhibitor Vemurafenib binds to BRAF-V600E. Consistent with this prediction, combinations of I3C and Vemurafenib more potently inhibited melanoma cell proliferation and reduced MITF-M levels in BRAF-V600E expressing melanoma cells compared to the effects of each compound alone. Thus, our results demonstrate that oncogenic BRAF-V600E is a new cellular target of I3C that implicate this indolecarbinol compound as a potential candidate for novel single or combination therapies for melanoma. © 2016 Wiley Periodicals, Inc.
    Print ISSN: 0899-1987
    Digitale ISSN: 1098-2744
    Thema: Medizin
    Publiziert von Wiley-Blackwell
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  • 7
    Publikationsdatum: 2016-09-18
    Beschreibung: Two interesting aspects of cell lines grown in 3D conditions are their distinct morphology and production of extracellular matrix (ECM). Also, it is known that 3D aggregates have different susceptibilities to damage-inducing agents compared to their 2D monolayer counterparts. We describe the effect of ECM on 3D aggregate morphology, the effect of cisplatin, bleomycin and UV on the 3D aggregates and 2D monolayers of the BMG-1 cell line. We also present a rapid method for analyzing cytotoxicity and anti-proliferative effects of 3D aggregates in 96-well plates. We utilized a single-step protocol using the dye resazurin. BMG-1 cells formed floating aggregates on 1% agarose hydrogels. The extent of ECM formed by them was dependent on number of cells seeded irrespective of the seeding density, which in turn directed the 3D aggregates compactness. The 3D aggregates were less susceptible to cisplatin and UV-induced cytotoxicity compared to 2D counterparts. The IC 50 value of cisplatin was elevated at 210 µg/ml for the aggregates compared to 170µg/ml for the monolayers. Exposure to UV for 10, 20 and 30 minutes gave inhibition values of 2.98%, 8%, 22.99% and 31.8% for the aggregates as compared to 3.06%, 7.5%, 39.4% and 46.7% for the monolayers. While bleomycin-induced effects were unapparent when analyzed by vital staining for the doses used, the rapid, single-step method in 96-well plates was able to provide a dose-response for cytotoxicity and anti-proliferative effects. Also, comparative analysis of results obtained from vital staining and the single-step method demonstrates the reliability of the assay described. This article is protected by copyright. All rights reserved
    Digitale ISSN: 1097-4652
    Thema: Biologie , Medizin
    Publiziert von Wiley-Blackwell
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  • 8
    Publikationsdatum: 2015-07-24
    Beschreibung: Author(s): Yang Wang, Xianli Zhang, Theodore A. Corcovilos, Aishwarya Kumar, and David S. Weiss Researchers manipulate atomic qubits individually in a three-dimensional optical lattice. [Phys. Rev. Lett. 115, 043003] Published Thu Jul 23, 2015
    Schlagwort(e): Atomic, Molecular, and Optical Physics
    Print ISSN: 0031-9007
    Digitale ISSN: 1079-7114
    Thema: Physik
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  • 9
    Publikationsdatum: 2017-10-28
    Beschreibung: Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs Nature Communications, Published online: 27 October 2017; doi:10.1038/s41467-017-01349-y Hyperoxia contributes to lung injury in bronchopulmonary dysplasia. The authors show that hyperoxia increases miR-34a expression in human neonates and in mouse models, and that pathology is ameliorated by miR-34a inhibition or by administration of its target angiopoietin-1
    Digitale ISSN: 2041-1723
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik
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  • 10
    Publikationsdatum: 2017-06-29
    Beschreibung: ABSTRACT Transcription factor TFII-I is a multifunctional protein implicated in the regulation of cell cycle and stress-response genes. Previous studies have shown that a subset of TFII-I associated genomic sites contained DNA-binding motifs for E2F family transcription factors. We analyzed the co-association of TFII-I and E2Fs in more detail using bioinformatics, chromatin immunoprecipitation, and co-immunoprecipitation experiments. The data show that TFII-I interacts with E2F transcription factors. Furthermore, TFII-I, E2F4, and E2F6 interact with DNA-regulatory elements of several genes implicated in the regulation of the cell cycle, including DNMT1 , HDAC1, CDKN1C and CDC27 . Inhibition of TFII-I expression led to a decrease in gene expression and in the association of E2F4 and E2F6 with these gene loci in human erythroleukemia K562 cells. Finally, TFII-I deficiency reduced the proliferation of K562 cells and increased the sensitivity towards doxorubicin toxicity. The results uncover novel interactions between TFII-I and E2Fs and suggest that TFII-I mediates E2F function at specific cell cycle genes. This article is protected by copyright. All rights reserved
    Digitale ISSN: 0091-7419
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Publiziert von Wiley-Blackwell
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