Publication Date:
2018-01-23
Description:
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Published online: 22 January 2018; doi:10.1038/s41556-017-0022-y RIP3 regulates mitochondrial metabolism. Yang et al. show that RIP3 activates the pyruvate dehydrogenase complex to enhance aerobic respiration and increase mitochondrial ROS during necroptosis, and MLKL is required for RIP3 translocation to mitochondria.
Print ISSN:
1465-7392
Electronic ISSN:
1476-4679
Topics:
Biology
,
Medicine
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