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  • 1
    Online-Ressource
    Online-Ressource
    New York, NY :Springer,
    Schlagwort(e): Peptide hormones. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (229 pages)
    Ausgabe: 1st ed.
    ISBN: 9780387254050
    Serie: Basic Science for the Cardiologist Series ; v.19
    DDC: 612.4/5
    Sprache: Englisch
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Boston, MA : Springer Science+Business Media, Inc
    Schlagwort(e): Medicine ; Cardiology ; Medicine & Public Health ; Cardiology ; Medicine ; Cardiovascular Diseases drug therapy ; Peptides physiology ; Natriuretic Agents therapeutic use ; Peptides therapeutic use ; Adrenomedullin ; Kardiovaskuläre Krankheit
    Beschreibung / Inhaltsverzeichnis: Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease. Toshio Nishikimi, MD, PhD, is an Associate Professor in the Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
    Materialart: Online-Ressource
    Seiten: Online-Ressource (X, 222 p. 35 illus, digital)
    ISBN: 9780387254050
    Serie: Basic Science for the Cardiologist 19
    RVK:
    RVK:
    Sprache: Englisch
    Anmerkung: Includes bibliographical references and index , Biochemistry of Adrenomedullin; Adrenomedullin Receptor and Signal Transduction; Adrenomedullin Gene; Adrenomedullin Expression and Secretion; Biological Action of Adrenomedullin; Circulating Adrenomedullin; Role of Adrenomedullin in Cardiovascular Diseases; Adrenomedullin as an Adipokine; Adrenomedullin Knockout Mouse and Transgenic Mouse; Pleiotropic Effect of Adrenomedullin: Lessons from Pure Adrenomedullin Knockout Mouse; Therapeutic Application of Adrenomedullin; Therapeutic Potentials of Adrenomedullin for Heart Failure and Pulmonary Hypertension
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. We investigated the effect of exercise on plasma adreno-medullin, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations and studied the relationship between these peptides and haemodynamic parameters in nine patients with old myocardial infarction (MI) and in eight normal subjects.2. The exercise protocol consisted of two fixed work loads (40 and 80 W) for 4 min each and venous blood samples were taken at rest, during each exercise stage and after exercise while monitoring the mean arterial pressure (MAP) and heart rate (HR). In MI, pulmonary arterial pressure (PAP), pulmonary capillary wedge pressure (PCWP), left ventricular end-diastolic pressure (LVEDP) and cardiac output (CO) were measured throughout exercise.3. Adrenomedullin levels did not significantly increase with exercise. Adrenomedullin levels correlated with PAP and PCWP at rest (P 〈 0.05). Atrial natriuretic peptide levels correlated with PAP, PCWP and LVEDP throughout exercise (P 〈 0.05) but, on multiple regression analysis, PCWP correlated only with ANP (P 〈 0.01). Brain natriuretic peptide levels correlated with LVEDP throughout exercise (P 〈 0.01) and its increment correlated closely with basal BNP levels at rest (P 〈 0.01).4. These results suggest that adrenomedullin does not respond to the acute haemodynamic changes of exercise, whereas ANP responds to it and PCWP is the major stimulus factor. Brain natriuretic peptide responds to exercise in proportion to the basal synthesis of BNP in patients with left ventricular dysfunction and LVEDP may play a role in increasing BNP during exercise.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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