ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Using an immunoblotting technique and goat antihuman C4, we observed five distinct electrophoretic variants of C4 in a panel of 60 random dogs. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of immunoprecipitated C4 showed that dog C4 is composed of three polypeptide subunit chains (α, β, and γ) and that structural variability occurs within the α- and γ-chain regions. Two distinct molecular weight forms of both the C4α- (α A and α B) and C4γ-(γ A and γ B) chain were detected. The variant forms of C4α and C4γ were found in association with particular C4 allotypes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00430323
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