In:
International Journal of Cancer, Wiley, Vol. 134, No. 11 ( 2014-06), p. 2595-2604
Abstract:
What's new? Noxin was previously identified in mice as a stress‐induced gene that may be an important component of the defense machinery of stressed cells. Here, the authors identified human Noxin as a novel cancer‐specific gene whose expression is cell cycle‐regulated and induced by ultraviolet radiation. Knockdown of hNoxin induced apoptosis of A549 cancer cells via p38 MAPK/p53 signaling. Overexpression of hNoxin suppressed DNA damage‐induced apoptosis. These data suggest that hNoxin has anti‐apoptotic activity that protects cancer cells against DNA damage. Knockdown of hNoxin reduced tumor growth in a mouse xenograft model, suggesting that hNoxin is a potential therapeutic target in cancer.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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