In:
International Journal of Cancer, Wiley, Vol. 134, No. 12 ( 2014-06-15), p. 2778-2788
Abstract:
What's new? This report demonstrates that epigenetic modifications, rather than mutations in known cancer‐related genes, are important and early events in hepatocellular carcinogenesis. In a mouse model of fibrosis‐associated liver cancer, the authors found no mutations in key tumor‐associated genes, but detected instead wide‐spread DNA demethylation of genes and repetitive elements as well as a decrease in suppressive histone methylation marks (H3K9me3) in tumor and associated non‐tumor liver tissue. They speculate that these epigenetic alterations may be causally linked to the development of liver tumors that arise from fibrosis and cirrhosis and could be therapeutically exploited for the treatment of these cancers in humans.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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