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  • 1
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 379, No. 6634 ( 2023-02-24)
    Kurzfassung: The Hayabusa2 spacecraft retrieved surface and subsurface samples from the carbonaceous near-Earth asteroid (162173) Ryugu, which was expected to be enriched in volatile species. The samples were collected from two locations, one undisturbed surface and the other including material excavated by an artificial impact. Unlike meteorites, these samples have experienced minimal alteration by Earth’s atmosphere. Ryugu is thought to have formed from material ejected (by an impact) from a parent body, which had experienced aqueous alteration (reactions with liquid water) ~4.56 billion years (Gyr) ago. Ryugu’s orbit later migrated from the main asteroid belt to become a near-Earth asteroid. RATIONALE Noble gases and nitrogen isotopes in Ryugu grains are inherited from Ryugu’s parent body and potentially provide information about the source of Earth’s volatile elements. Noble gas isotopes can also be used to assess the orbital evolution and recent surface activities of Ryugu. We pelletized ~0.8-mm-diameter Ryugu grains and investigated their mineralogy before carrying out isotope measurements. We measured the concentrations and isotopic compositions of noble gases and nitrogen, extracted by stepped heating, with mass spectrometers. RESULTS The mineralogy of the Ryugu grains is similar to Ivuna-type carbonaceous (CI) chondrite meteorites. Fine-grained hydrous silicates (phyllosilicates), produced through aqueous alteration of primary minerals, compose the major fraction of the samples. This is consistent with infrared spectroscopic observations of the asteroid. Iron oxide, iron sulfides, and carbonates are also found within the matrix. Noble gas isotopes are dominated by primordially trapped gases. Their abundances are mostly similar to the highest found in a CI chondrite, with some grains having several times higher concentrations than the highest CI value. Isotopic compositions and concentrations of nitrogen vary between the Ryugu grains, with divergence from the CI chondrite composition. The nitrogen concentrations in four Ryugu grains are one-half to one-third the CI values, and the 15 N/ 14 N ratio is also lower. The Ryugu grains with compositions farthest from the CI values are similar to the composition of a dehydrated CI chondrite. Only two surface samples, out of the 16 Ryugu grains measured, have clear signs of noble gases derived from solar wind (SW). Their abundances correspond to SW exposure durations of ≳3500 and ≳250 years at the current orbit, whereas most of the grains were exposed for ≳1 to ≳50 years. Cosmic ray–produced 21 Ne concentrations vary, with no systematic difference between the sample collection sites. The estimated cosmic ray exposure (CRE) ages for the surface and subsurface samples are 5.3 ± 0.9 and 5.2 ± 0.8 million years (Myr), assuming irradiations at 2 to 5 g cm −2 and 150 g cm −2 , respectively. This is consistent with the expected surface residence time under near-Earth impact rates. We infer that Ryugu’s orbit migrated from the main asteroid belt to the near-Earth region ~5 Myr ago. About 30% of cosmogenic 21 Ne, corresponding to a CRE age of ~1 Myr, was released in gas-extraction steps at 100°C, indicating that the Ryugu samples have not experienced heating above 100°C within the past 1 Myr. Previous studies have suggested that Ryugu experienced an orbital excursion much closer to the Sun. If this is the case, this excursion must have occurred ≳1 Myr ago. CONCLUSION The mineralogical and noble gas measurements show that the Ryugu samples are similar to CI chondrites. The nitrogen data indicate a heterogeneous distribution of nitrogen-carrying materials with different compositions, one of which has been lost from Ryugu grains to varying degrees. The CRE age of ~5 Myr and the implanted SW are records of the recent irradiation at the current near-Earth orbit of Ryugu. Inferred formation and history of Ryugu. Ryugu’s parent body formed in the early Solar System, incorporating primordial noble gases and nitrogen, followed by aqueous alteration ~4.56 Gyr ago. Ryugu formed from the accumulation of fragments of the parent body ejected by an impact, at an unknown date. Ryugu migrated to its current near-Earth orbit ~5 Myr ago. Ryugu might have experienced another change in orbit, bringing it closer to the Sun (“Path A”), or remained in the same near-Earth orbit (“Path B”).
    Materialart: Online-Ressource
    ISSN: 0036-8075 , 1095-9203
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2023
    ZDB Id: 128410-1
    ZDB Id: 2066996-3
    ZDB Id: 2060783-0
    SSG: 11
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 107, No. 12 ( 2010-03-23), p. 5622-5627
    Kurzfassung: Neuregulin-1 (NRG1) and Disrupted-in-Schizophrenia-1 (DISC1) are promising susceptibility factors for schizophrenia. Both are multifunctional proteins with roles in a variety of neurodevelopmental processes, including progenitor cell proliferation, migration, and differentiation. Here, we provide evidence linking these factors together in a single pathway, which is mediated by ErbB receptors and PI3K/Akt. We show that signaling by NRG1 and NRG2, but not NRG3, increase expression of an isoform of DISC1 in vitro. Receptors ErbB2 and ErbB3, but not ErbB4, are responsible for transducing this effect, and PI3K/Akt signaling is also required. In NRG1 knockout mice, this DISC1 isoform is selectively reduced during neurodevelopment. Furthermore, a similar decrease in DISC1 expression is seen in β-site amyloid precursor protein cleaving enzyme–1 (BACE1) knockout mice, in which NRG1/Akt signaling is reportedly impaired. In contrast to neuronal DISC1 that was reported and characterized, expression of DISC1 in other types of cells in the brain has not been addressed. Here we demonstrate that DISC1, like NRG and ErbB proteins, is expressed in neurons, astrocytes, oligodendrocytes, microglia, and radial progenitors. These findings may connect NRG1, ErbBs, Akt, and DISC1 in a common pathway, which may regulate neurodevelopment and contribute to susceptibility to schizophrenia.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2010
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 119, No. 1 ( 2022-01-05)
    Kurzfassung: The development of a plastic root system is essential for stable crop production under variable environments. Rice plants have two types of lateral roots (LRs): S-type (short and thin) and L-type (long, thick, and capable of further branching). LR types are determined at the primordium stage, with a larger primordium size in L-types than S-types. Despite the importance of LR types for rice adaptability to variable water conditions, molecular mechanisms underlying the primordium size control of LRs are unknown. Here, we show that two WUSCHEL-related homeobox ( WOX ) genes have opposing roles in controlling LR primordium (LRP) size in rice. Root tip excision on seminal roots induced L-type LR formation with wider primordia formed from an early developmental stage. QHB/OsWOX5 was isolated as a causative gene of a mutant that is defective in S-type LR formation but produces more L-type LRs than wild-type (WT) plants following root tip excision. A transcriptome analysis revealed that OsWOX10 is highly up-regulated in L-type LRPs. OsWOX10 overexpression in LRPs increased the LR diameter in an expression-dependent manner. Conversely, the mutation in OsWOX10 decreased the L-type LR diameter under mild drought conditions. The qhb mutants had higher OsWOX10 expression than WT after root tip excision. A yeast one-hybrid assay revealed that the transcriptional repressive activity of QHB was lost in qhb mutants. An electrophoresis mobility shift assay revealed that OsWOX10 is a potential target of QHB. These data suggest that QHB represses LR diameter increase, repressing OsWOX10 . Our findings could help improve root system plasticity under variable environments.
    Materialart: Online-Ressource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: Proceedings of the National Academy of Sciences
    Publikationsdatum: 2022
    ZDB Id: 209104-5
    ZDB Id: 1461794-8
    SSG: 11
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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