In:
ChemMedChem, Wiley, Vol. 16, No. 2 ( 2021-01-19), p. 340-354
Kurzfassung:
Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PL pro ) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor ( R )‐5‐amino‐2‐methyl‐N‐(1‐(naphthalen‐1‐yl)ethyl) benzamide ( 2 b ), which is known to bind into the S3 and S4 pockets of the SARS‐CoV PL pro . Moreover, we report the discovery of isoindolines as a new class of potent PL pro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS‐CoV‐2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS‐CoV PL pro are valuable starting points for the development of new pan‐coronaviral inhibitors.
Materialart:
Online-Ressource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.202000548
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2021
ZDB Id:
2209649-8
SSG:
15,3
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