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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Climate dynamics 15 (1999), S. 277-291 
    ISSN: 1432-0894
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract  Intermittent convection and its consequences on the stability of the thermohaline circulation are investigated with an oceanic global circulation model (OGCM) and simple box models. A two-box model shows that intermittency is a consequence of the non-linearity of the equation of state and of the ratio of heat and freshwater fluxes at surface versus the fluxes at depth. Moreover, it only occurs in areas, where the instability of the water column is caused by temperature or by salinity. Intermittency is not necessarily suppressed by long restoring times. Because intermittent convection causes temporal variations of the ocean-atmosphere fluxes, an OGCM cannot reach an exact equilibrium. After a switch to mixed boundary conditions, changes of the convective activity occur in areas where intermittency is observed. Intermittent convection becomes either continuous or is stopped depending on the method used for calculating the freshwater fluxes. Advective and diffusive fluxes between these regions and their surroundings change in order to balance the altered convective fluxes. A comparison between the OGCM and a six-box model illustrates that this may lead to an alteration of adjacent deep convection and of the related deep water formation.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Publikationsdatum: 2017-06-15
    Repository-Name: EPIC Alfred Wegener Institut
    Materialart: Article , peerRev
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Publikationsdatum: 2022-05-26
    Beschreibung: Author Posting. © American Meteorological Society, 2011. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 24 (2011): 2429–2449, doi:10.1175/2010JCLI3997.1.
    Beschreibung: Continuous estimates of the oceanic meridional heat transport in the Atlantic are derived from the Rapid Climate Change–Meridional Overturning Circulation (MOC) and Heatflux Array (RAPID–MOCHA) observing system deployed along 26.5°N, for the period from April 2004 to October 2007. The basinwide meridional heat transport (MHT) is derived by combining temperature transports (relative to a common reference) from 1) the Gulf Stream in the Straits of Florida; 2) the western boundary region offshore of Abaco, Bahamas; 3) the Ekman layer [derived from Quick Scatterometer (QuikSCAT) wind stresses]; and 4) the interior ocean monitored by “endpoint” dynamic height moorings. The interior eddy heat transport arising from spatial covariance of the velocity and temperature fields is estimated independently from repeat hydrographic and expendable bathythermograph (XBT) sections and can also be approximated by the array. The results for the 3.5 yr of data thus far available show a mean MHT of 1.33 ± 0.40 PW for 10-day-averaged estimates, on which time scale a basinwide mass balance can be reasonably assumed. The associated MOC strength and variability is 18.5 ± 4.9 Sv (1 Sv ≡ 106 m3 s−1). The continuous heat transport estimates range from a minimum of 0.2 to a maximum of 2.5 PW, with approximately half of the variance caused by Ekman transport changes and half caused by changes in the geostrophic circulation. The data suggest a seasonal cycle of the MHT with a maximum in summer (July–September) and minimum in late winter (March–April), with an annual range of 0.6 PW. A breakdown of the MHT into “overturning” and “gyre” components shows that the overturning component carries 88% of the total heat transport. The overall uncertainty of the annual mean MHT for the 3.5-yr record is 0.14 PW or about 10% of the mean value.
    Beschreibung: This research was supported by the U.S. National Science Foundation under Awards OCE0241438 and OCE0728108, by the U.K. RAPID Programme (RAPID Grant NER/T/S/2002/00481), and by the U.S. National Oceanic and Atmospheric Administration, as part of its Western Boundary Time Series Program.
    Schlagwort(e): Atlantic Ocean ; Meridonial overturning circulation ; Sea surface temperature ; Transport ; Anomalies
    Repository-Name: Woods Hole Open Access Server
    Materialart: Article
    Format: application/pdf
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Publikationsdatum: 2012-04-25
    Beschreibung: HIV-1 protease is an important target for the treatment of HIV/AIDS. However, drug resistance is a persistent problem and new inhibitors are needed. An approach toward understanding enzyme chemistry, the basis of drug resistance, and the design of powerful inhibitors is to establish the structure of enzymatic transition states. Enzymatic transition structures can be established by matching experimental kinetic isotope effects (KIEs) with theoretical predictions. However, the HIV-1 protease transition state has not been previously resolved using these methods. We have measured primary 14C and 15N KIEs and secondary 3H and 18O KIEs for native and multidrug-resistant HIV-1 protease (I84V). We observed 14C KIEs (14V/K) of 1.029 ± 0.003 and 1.025 ± 0.005, 15N KIEs (15V/K) of 0.987 ± 0.004 and 0.989 ± 0.003, 18O KIEs (18V/K) of 0.999 ± 0.003 and 0.993 ± 0.003, and 3H KIEs (3V/K) KIEs of 0.968 ± 0.001 and 0.976 ± 0.001 for the native and I84V enzyme, respectively. The chemical reaction involves nucleophilic water attack at the carbonyl carbon, proton transfer to the amide nitrogen leaving group, and C-N bond cleavage. A transition structure consistent with the KIE values involves proton transfer from the active site Asp-125 (1.32 Å) with partial hydrogen bond formation to the accepting nitrogen (1.20 Å) and partial bond loss from the carbonyl carbon to the amide leaving group (1.52 Å). The KIEs measured for the native and I84V enzyme indicate nearly identical transition states, implying that a true transition-state analogue should be effective against both enzymes.
    Print ISSN: 0027-8424
    Digitale ISSN: 1091-6490
    Thema: Biologie , Medizin , Allgemeine Naturwissenschaft
    Standort Signatur Einschränkungen Verfügbarkeit
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