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  • Articles  (84)
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  • 1
    Electronic Resource
    Electronic Resource
    Exploring the Conformational Behavior of Rigid Porphyrin-Quinone Systems by High-Temperature MD Simulations and Temperature-Dependent 1H-NMR Experiments (1996)
    Springer
    Journal of molecular modeling 2 (1996), S. 383-385 
    Details
    ISSN: 0948-5023
    Keywords: High-Temperature MD Simulations ; Confor-mational Analysis ; Porphyrin-Quinone Systems ; Photosynthesis Models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Photoinduced electron transfer reactions play an important role in the primary step of the biological photosynthesis process. In an attempt to understand better the mechanism of the charge separation organic donor-acceptor molecules containing porphyrins and quinones were designed as photosynthesis models. In order to study the structure dependence of the photoinduced electron transfer twofold and fourfold bridged porphyrin-quinone systems with increasing donor-acceptor distance were synthesized (Figure 1) [1, 2, 3]. It was assumed that in these molecules the porphyrin and quinone should be linked in a rigid and well-defined orientation. To verify this assumption the conformational behavior of these systems was studied by high-temperature MD simulations in combination with conformational analysis of selected minimized structures [4, 5].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0089460020383
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of the Conformational Behavior of Sialyllactose Complexed with the two Viral Attachment Proteins Influenza A Hemagglutinin and the Murine Polyomavirus (1997)
    Springer
    Journal of molecular modeling 3 (1997), S. 408-414 
    Details
    ISSN: 0948-5023
    Keywords: Keywords: Protein-Carbohydrate interactions ; MD simulations ; Flexibility ; Sialyllactose ; Influenza A virus hemagglutinin ; Murine polyoma virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The attachment of a virus to the host cell surface is influenced by enthalpic and entropic factors. A detailed evaluation of all possible energetic interactions including the effects of solvent molecules seems to be a promising way to gain deeper insights in the overall process of binding. Here we performed intensive molecular dynamics studies to compare the conformational space available for the unbound sialyllactose in aqueous solution and when complexed with influenza A hemagglutinin and the murine polyoma virus. In general the conformational freedom of sialyllactose is considerably reduced compared to the free state. Remarkably, two different conformations of the Siaα(2-3)Galβ glycosidic linkages are preferred (which are both populated in the free state) when complexed with either protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s008940050058
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  • 3
    Electronic Resource
    Electronic Resource
    The early Miocene onset of a ventilated circulation regime in the Arctic Ocean (2007)
    [s.l.] : Nature Publishing Group
    Nature 447 (2007), S. 986-990 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Deep-water formation in the northern North Atlantic Ocean and the Arctic Ocean is a key driver of the global thermohaline circulation and hence also of global climate. Deciphering the history of the circulation regime in the Arctic Ocean has long been prevented by the lack of data from cores ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05924
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  • 4
    Electronic Resource
    Electronic Resource
    Contribution of Southern Ocean surface-water stratification to low atmospheric CO 2 concentrations during the last glacial period (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 929-935 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The nitrogen-isotope record preserved in Southern Ocean sediments, along with several geochemical tracers for the settling fluxes of biogenic matter, reveals patterns of past nutrient supply to phytoplankton and surface-water stratification in this oceanic region. Areal averaging of these spatial ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/40073
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  • 5
    Electronic Resource
    Electronic Resource
    A confocal fiber-coupled single-lens theta microscope (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 2956-2963 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A confocal theta microscope using a single water-immersion objective lens is described. The system is based on the Zeiss Axioplan universal microscope, such that the illumination light is coupled into, and the detected light out of, the microscope optics via optical fibers attached to the reflector slider of the microscope. Conventional wide-field, laser-scanning confocal, confocal theta, and 4Pi-confocal theta microscopy modes are available with the system. As the design can be easily adapted to other microscopes, objective lenses, and wavelengths, it allows confocal theta techniques to be implemented in many standard systems. The design constraints and specifications for the microscope are given, as well as a demonstration of its performance. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149040
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  • 6
    Electronic Resource
    Electronic Resource
    Multiple mantle sources during island arc magmatism: U–Pb and Hf isotopic evidence from the Kohistan arc complex, Pakistan (2002)
    Oxford, UK : Blackwell Science Ltd
    Terra nova 14 (2002), S. 0 
    Details
    ISSN: 1365-3121
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: This paper presents high-precision U–Pb ages and initial Hf isotopic compositions of zircon from mafic to felsic rocks of the Kohistan Arc Complex, Pakistan. Three magmatic pulses tapping geochemically different reservoirs are distinguished. Partial melting of mantle with MORB-type isotopic characteristics generated 99–92-Ma-old magmas. Plutonism around 85 Ma tapped a more fertile mantle source, most likely consisting of a 〉600-Ma-old metasomatically enriched mantle, or of mantle contaminated by an old sedimentary component; 82-Ma-old felsic peraluminous dykes have MORB-type isotopic compositions considered to be inherited from remelting earlier magmas in the deep base of the arc. The isotopic results demonstrate several and rather rapid changes in melt source region during arc development. They also show that there was subordinate continental influence and negligible importance of slab components for the Hf budget during the generation of the Kohistan Arc Complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3121.2002.00432.x
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  • 7
    Electronic Resource
    Electronic Resource
    The transition from rifting to sea-floor spreading within a magma-poor rifted margin: field and isotopic constraints (2002)
    Oxford UK : Blackwell Science Ltd
    Terra nova 14 (2002), S. 0 
    Details
    ISSN: 1365-3121
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: We provide new geological and isotope geochemical constraints on the evolution from continental rifting to sea-floor spreading along a segment of the Jurassic Tethyan margin exposed in the Platta and Err nappes (eastern Central Alps). Field observations show that the ocean–continent transition zone is characterized by oceanward-dipping detachment faults leading to the exhumation of subcontinental mantle rocks subsequently intruded by gabbro bodies and dolerite dikes, and covered by pillow basalts and radiolarites. Zircons extracted from gabbros and albitite yield concordant U–Pb ages of 161 ± 1 Ma; their initial ɛHf (+ 14.4 to + 14.9) as well as bulk rock ɛNd values of from gabbros and basalts (+ 7.3 to + 9.5) point to a MORB-type depleted mantle source. These data suggest that the onset of magmatic activity coincides with the latest phase of mantle exhumation along low-angle detachment faults and may be controlled by upwelling asthenosphere beneath a zone of exhumed continental mantle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3121.2002.00406.x
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  • 8
    Electronic Resource
    Electronic Resource
    Plasticity of the landing response of Drosophila melanogaster (1991)
    Springer
    Journal of comparative physiology 169 (1991), S. 323-330 
    Details
    ISSN: 1432-1351
    Keywords: Habituation ; Contralateral sensitization ; Leaky integrator ; Rotation detectors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fruitflies (Drosophila melanogaster) may respond with landing reactions in tethered flight to unilateral progressive motion of single vertical dark stripes. The response frequency to repeated unilateral stimulation has a characteristic time course, a fast increase followed by a slower decrease. This behaviour is explained by the habituation of the input channels to a leaky integrator. The half-life of the integrated signal is in the range of 1 s. ‘Contralateral sensitization’ (CoS) describes the sensitization of the landing response to unilateral stimuli by preceding contralateral stimulation. It acts by increasing the initial reactivity, which habituates. The effects of CoS are thus still obvious after 1 min of repetitive stimulation. CoS can effectively be mediated by movement stimuli as well as by flickering light. We also show that binocular rotation rather than unilateral back to front motion inhibits the landing response (in the monocular part of the visual field). The biological significance of the described temporal characteristics of the landing response system and their possible neuronal basis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206996
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of ryanodine on myocardial calcium (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 35-47 
    Details
    ISSN: 1432-1912
    Keywords: Guinea Pig Atrial Muscle ; Ryanodine ; Ryanodine Steady-State Condition ; Post-Rest Potentiation ; Calcium Exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of ryanodine and ryanodine steady-state condition (RSSC) on contractile-related calcium were examined in isolated guinea pig left atrial muscle. 1. RSSC is a specific irreversible condition occurring after a brief exposure to 1×10−7 M ryanodine, followed by washing. It is characterized by elimination of the contraction following a 10-sec rest interval (post-rest) and prolongation of the associated action potential duration (AP50%) from 78.9 to 160.8 msec with minimal alteration in steady-state tension development determined at 1 Hz. 2. Induction of RSSC with a ryanodine-bovine serum albumin conjugate produced similar alterations in post-rest contractile strength and action potential duration. 3. In the presence of 1×10−7 M ryanodine, guinea pig left atria exhibit a significant increase in total 45Ca efflux from two rapidly exchangeable compartments (compartment 1, t 1/2=1.58 min; compartment 2, t 1/2-8.20 min). 4. In atria loaded after the induction of RSSC, total 45Ca release was significantly reduced by 7.2% of the total exchange. 5. The 45Ca exchange space for RSSC atria was reduced from 23.22±0.81 to 19.85±1.22 ml per 100 g muscle without a significant reduction in the total exchange space. 6. From these results, it is concluded that the effects of low concentrations of ryanodine and RSSC are to alter the contractile calcium levels of the tissue, primarily from sarcolemmal membrane sites which regulate post-rest contractile strength and action potential duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499988
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  • 10
    Electronic Resource
    Electronic Resource
    Über die Versorgung des Bruchsackes und dessen Verwendung zum plastischen Verschluß der Bruchpforte bei Leisten- und Schenkelhernien (1952)
    Springer
    Langenbeck's archives of surgery 271 (1952), S. 240-252 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über eine neue Methode der Hernienplastik bei Inguinal- und Cruralhernien berichtet, wobei auf folgende 3 Momente besonders Wert gelegt wird: 1. Die sorgfältige Präparation des Bruchsackes und seine ordnungsgemäße Versorgung durch Verlagerung nach medial und oben nach vorheriger Torsion sind die wichtigen Voraussetzungen für die Dauerheilung der Leisten- und Schenkelhernien. 2. Die plastische Wiederherstellung der Bauchwand im Bereiche des Trig. ing. ist grundsätzlich nach den vonBassini aufgestellten Richtlinien vorzunehmen, das Vorgehen wird dabei beim Einzelfall durch die Verhältnisse im Leistenkanal bestimmt. Als ganz besonders wichtig wird bei medialer Leistenhernie und bei cruraler Hernie betrachtet, das Schambeinperiost in die Naht mitzufassen. 3. Der Bruchsack wird bei allen großen Hernien der besprochenen Bruchformen zur Vermehrung der Bauchwandschichten verwendet. Dieser erhöht die Verschlußfestigkeit der Bruchpforte und schützt die Muskulatur vor Quetschung durch das Nahtmaterial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403805
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