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  • 1
    Digitale Medien
    Digitale Medien
    Role of the cellular environment in interstitial stem cell proliferation in Hydra (1991)
    Springer
    Development genes and evolution 200 (1991), S. 269-276 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Stem cells ; Nerve cells ; Differentiation ; Microenvironment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary The role of the cellular environment on hydra stem cell proliferation and differentiation was investigated by introduction of interstitial cells into host tissue of defined cellular composition. In epithelial tissue lacking all non-epithelial cells the interstitial cell population did not grow but differentiated into nerve cells and nematocytes. In host tissue with progressively increased numbers of nerve cells growth of the interstitial cell population was positively correlated to the nerve cell density. In agreement with previous observations (Bode et al. 1976), growth of the interstitial cell population was also found to be negatively correlated to the level of interstitial cells present. The strong correlation between the growth of the interstitial cell population and the presence of interstitial cells and nerve cells implies that interstitial cell proliferation is controlled by a feedback signal from interstitial cells and their derivatives. Our results suggest that the cellular environment of interstitial cells provides cues which are instrumental in stem cell decision making.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00241296
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  • 2
    Digitale Medien
    Digitale Medien
    The heat shock response in hydra: immunological relationship of hsp60, the major heat shock protein of Hydra vulgaris, to the ubiquitous hsp70 family (1991)
    Springer
    Hydrobiologia 216-217 (1991), S. 513-517 
    Details
    ISSN: 1573-5117
    Schlagwort(e): Hydra vulgaris ; heat shock ; hsp60 ; hsp70 ; immunology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The major heat shock protein (hsp) of Hydra vulgaris has recently been found to be a 60 kDa protein. Since in all organisms studied so far, the major heat shock protein is a 70 kDa protein, we have analyzed the relationship of hydra hsp60 to the highly conserved 70 kDa heat shock protein family. Genes and proteins related to the 70 kDa class of stress proteins are present in hydra. However, antibodies known to cross-react with hsp70 proteins in several different organisms do not cross-react with hydra hsp60 suggesting that hsp60 is not related to the conserved hsp70 proteins.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00026507
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  • 3
    Digitale Medien
    Digitale Medien
    Die Isopropylgruppe als stereochemische Sonde; 13C-NMR-Untersuchungen an Menthan- und Isomenthanderivaten (1978)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1978 (1978), S. 87-97 
    Details
    ISSN: 0075-4617
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: The Isopropyl Group as a Stereochemical Probe; C-NMR Investigations of Menthane- and Isomenthane DerivativesThe 13C-NMR spectra of 22 menthane and isomenthane derivatives are reported. The influence of substituents on the chemical shifts of the ring carbon atoms is discussed. The chemical shifts of the signals of the (CH3)2C8H - C4H(CH2-)2 fragment depend strongly on the position of the rotamer equilibrium around the C8-C4-bond. Hence the isopropyl group can be used as a probe for differentiation between constitutional and stereoisomeric cyclohexane derivatives as well as for the estimation of conformational equilibria.
    Notizen: Die 13C-NMR-Spektren von 22 Menthan- und Isomenthanderivaten werden interpretiert, und der Substituenteneinfluß auf die 13C-chemische Verschiebung der Gerüst-C-Atome wird diskutiert. Es zeigt sich, daß die Verschiebungen der Signale des Fragments (CH3)2C8H - C4H(CH2-)2 stark von der Lage des Rotamerengleichgewichts um die C8-C4-Bindung abhängen. Die Isopropylgruppe kann daher als Sonde zur Unterscheidung von konstitutions-und stereoisomeren Cyclohexanderivaten sowie zur Abschätzung von Konformationsgleichgewichten benutzt werden.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.197819780111
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  • 4
    Digitale Medien
    Digitale Medien
    Aliphatische α-substituierte Nitrosoverbindungen, II. Zur Chemie und Stereochemie einiger α-Chlornitrosoterpene (1975)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1975 (1975), S. 1009-1017 
    Details
    ISSN: 0075-4617
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Aliphatic α-Substituted Nitroso Compounds, II. - Chemistry and Stereochemistry of Some α-Chloro Nitroso TerpenesDiastereomeric α-chloro nitroso compounds derived from carvomenthone, 3-methylcyclo- hexanone, fenchone and camphor have been synthesized. Their stereochemistry is discussed in terms of 1H-NMR and CD data.
    Notizen: Diastereomere α-Chlornitrosoverbindungen, die sich von Carvomenthon, 3-Methylcyclo- hexanon, Fenchon und Campher ableiten, werden dargestellt und einige ihrer Umsetzungen untersucht. Die Stereochemie der Verbindungen, erschlossen aus ihren 1H-NMR- und CD- Spektren, wird diskutiert.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.197519750518
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  • 5
    Digitale Medien
    Digitale Medien
    Aliphatische a-substituierte Nitrosoverbindungen, III. Zur Photochemie von 2-Chlor-2-nitroso- und 3-Chlor-3-nitroso-p-menthan (1979)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1979 (1979), S. 905-913 
    Details
    ISSN: 0170-2041
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Aliphatic a-Substituted Nitroso Compounds, III. - Photochemistry of 2-Chloro-2-nitroso- and 3-Chloro-3-nitroso-p-methaneThe diastereomeric 2-chloro-2-nitroso- and 3-chloro-3-nitroso-p-menthanes epimerize during photolysis. This result, together with the evaluation of the quantum yields of the photoreactions and the detection of an intermediate aminyl oxide, place our concept of the mechanism of photolysis of geminally substituted nitroso compounds on a firmer footing.The products of the polyphosphoric acid cyclization of the 2-(o-iodophenylacetyl)malonate 3 have been reinvestigated and their structures revised. The reaction proceeds with loss of iodine, presumably forming 7, which is oxidized to 8 (instead of 5) followed by dehydration to 11 (instead of 2) and equilibration to hydroquinone 10 (instead of 6).
    Notizen: Die diastereomeren 2-Chlor-2-nitroso- und 3-Chlor-3-nitroso-p-menthane epimerisieren während der Photolyse. Dieses Ergebnis, die Auswertung der Quantenausbeuten der Photoreaktionen und der Nachweis eines intermediären Aminyloxids verfeinern die früheren Aussagen über den Mechanismus der Photolyse von geminal substituierten Nitrosoverbindungen.Die durch Polyphosphorsäure-Cyclisierung des 2-(o-Iodphenylacetyl)malonsäureesters 3 erhaltenen Produkte wurden erneut untersucht und ihre Strukturen korrigiert. Vermutlich ergibt Iodabspaltung zunächst 7, und nachfolgende Oxidation 8 (statt 5). Verbindung 8 wird zu 11 (statt 2) de-hydratisiert. 11 steht mit 10 (statt 6) im Gleichgewicht.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.197919790620
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  • 6
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    Clinicopathological characteristics predict lymph node metastases in ypT0-2 rectal cancer after chemoradiotherapy (2016)
    Wiley-Blackwell
    Details
    Publikationsdatum: 2016-06-07
    Beschreibung: Background Changes in rectal cancer treatment include increasing emphasis on organ preservation. Local excision after chemoradiotherapy (CRT) for rectal cancer with excellent clinical response reduces morbidity and mortality compared to total mesorectal excision, although residual lymph node metastases (LNM) may cause local recurrence. Our aim is to identify clinicopathological factors predicting the presence of residual LNM in rectal cancer patients with ypT0-2 tumours after neo-adjuvant CRT. These risk factors may help select patients who can be spared radical surgery without compromising oncological outcomes. Methods Rectal cancer patients with ypT0-2 tumours after CRT and radical resection from five centres treated between June 1999 and February 2012 were included. Histopathology was extensively reviewed. Clinicopathological characteristics and their association with residual LNM were investigated. Results Out of 657 consecutive CRT treated rectal cancer patients 210 with ypT0-2 disease were included. Residual nodal disease was found in 44 cases (21.0%). Independent predictors of LNM were clinical nodal involvement (cN+) (OR 2.79 [95% CI 1.04-7.48], p=0.042), “high grade” histopathology assessed in the post-CRT resection specimen (OR 6.46 [95% CI 1.23-34.02], p=0.028), and residual tumour diameter ≥10mm (OR 2.54 [95% CI 1.06-6.09], p=0.036). An algorithm combining these factors adequately stratified patients according to LNM risk, independently of ypT category Conclusions Clinical nodal involvement, “high grade” histopathology, and residual tumour diameter ≥10mm are strong and independent predictors of residual nodal disease in rectal cancer patients with ypT0-2 tumours after CRT. Risk stratification based on these factors may help identify patients suitable for organ preserving therapy and should be validated in appropriately selected populations. This article is protected by copyright. All rights reserved.
    Print ISSN: 0309-0167
    Digitale ISSN: 1365-2559
    Thema: Medizin
    Publiziert von Wiley-Blackwell
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