ISSN:
1434-193X
Schlagwort(e):
Glycosides
;
Clusters
;
Noncovalent interactions
;
Ligands
;
Receptors
;
Chemistry
;
General Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
A series of p-substituted aryl α-D-mannosides was synthesized and tested with regard to their inhibitory capacity in the hemagglutination of guinea pig erythrocytes by type 1 fimbriated Escherichia coli. Synthesis of the bivalent, phenyl-linked mannoside cluster 10 was complicated by orthoester formation during the glycosylation reaction. Surprisingly, the inhibitory potency of 10 was lower than that of p-nitrophenyl α-D-mannoside (1) and this is an important finding for the further design of clustered ligands.
Materialart:
Digitale Medien
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