Electronic Resource
Springer
Naunyn-Schmiedeberg's archives of pharmacology
315 (1980), S. 63-67
ISSN:
1432-1912
Keywords:
Phenytoin
;
Methotrexate
;
Anticonvulsants
;
Calcium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Administration of phenytoin for 5 days significantly reduces oral absorption and bone uptake of radiolabelled calcium in mice. Acute treatment with phenytoin had no effect on calcium disposition. Pretreatment (1–5 days) with phenobarbital also had no effect of calcium disposition. Methotrexate pretreatment for 5 days increased the bone uptake of radiolabelled calcium presumably by decreasing calcium renal clearance. It is concluded that phenytoin induced reduction in calcium metabolism is unrelated to a state of functional folate deficiency.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00504231
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