ISSN:
1432-0738
Keywords:
Benzene
;
Bleomycin
;
Low molecular weight iron
;
Lipid peroxidation
;
Superoxide radical
;
Myelotoxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract An accumulation of low molecular weight (LMW) bleomycin detectable iron in the bone marrow was observed after administration of benzene (IP 0.5 ml/kg, daily) for 5 and 10 days in female albino rats. However, this LMW iron was not detectable in the bone marrow of rats from the control group. Studies of bone marrow fractionation showed that the maximum accumulation of this LMW iron was in the mitochondrial fraction. An increase in the activity of superoxide dismutase and lipid peroxidation was also noticed in the benzene exposed groups.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01972997
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