ISSN:
1434-9949
Keywords:
Galactosamine
;
Glucosamine
;
Polymorphonuclear Leukocyte
;
Enzyme Secretion
;
Superoxide Anion
;
Rheumatoid Arthritis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This study shows that N-acetyl-galactosamine and N-acetyl-glucosamine and diminish the production of superoxide anion from cytochalasin-B treated PMNs stimulated with FMLP. Inhibition ranged from 80.9% to 1.8%. N-acetyl-galactosamine was superior to N-acetyl-glucosamine, but both showed their action in a dose — related fashion. The mannosamine may diminish the superoxide production, but without a statistical significance. Other sugars such as L-fucose, D-fucose and D-glucose failed to induce inhibition of superoxide generation. Previous reports showed that sugars interfere with carbohydrates lectins interaction. This study shows that aminosugars can do more than interfere with carbohydrates-lectin interaction. The mechanism is not completely known yet. The question whether aminosugars affect cell-cell interaction, regulation of respiratory burst, inflammatory mediators functions, or the glucose uptake and utilization needs further study.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02207968
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