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Inhibition of superoxide anion release from human polymorphonuclear leukocytes by N-acetyl-galactosamine and N-acetyl-glucosamine (1992)

Kamel, M. ; Alnahdi, M.

Springer

Clinical rheumatology 11 (1992), S. 254-260

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ISSN: 1434-9949

Keywords: Galactosamine ; Glucosamine ; Polymorphonuclear Leukocyte ; Enzyme Secretion ; Superoxide Anion ; Rheumatoid Arthritis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary This study shows that N-acetyl-galactosamine and N-acetyl-glucosamine and diminish the production of superoxide anion from cytochalasin-B treated PMNs stimulated with FMLP. Inhibition ranged from 80.9% to 1.8%. N-acetyl-galactosamine was superior to N-acetyl-glucosamine, but both showed their action in a dose — related fashion. The mannosamine may diminish the superoxide production, but without a statistical significance. Other sugars such as L-fucose, D-fucose and D-glucose failed to induce inhibition of superoxide generation. Previous reports showed that sugars interfere with carbohydrates lectins interaction. This study shows that aminosugars can do more than interfere with carbohydrates-lectin interaction. The mechanism is not completely known yet. The question whether aminosugars affect cell-cell interaction, regulation of respiratory burst, inflammatory mediators functions, or the glucose uptake and utilization needs further study.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02207968

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Massenspektrometrische Untersuchungen an 1.1-Difluorcyclopropanen (1976)

Kamel, M. ; Riepe, W.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 11 (1976), S. 79-85

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ISSN: 0030-493X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Mass spectra and fragmentation patterns of several substituted 1,1-difluorocyclopropanes have been investigated. Trends in fragmentation probabilities of different difluorocyclopropanes seem to be related qualitatively to well known empirical substituent effects.

Notes: Die Massenspektren von verschiedenen substituierten 1.1-Difluorcyclopropanen wurden aufgenommen und ihr Fragmentierungsverhalten untersucht. die Tendenzen in den Bildungswahrscheinlichkeiten der Bruchstükionen bei verschiedenen Difluorcyclopropanen lassen sich qualitativ mit bekanten empirischen Substituenteneffekten erklären.

Additional Material: 4 Ill.