GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 357-360 
    ISSN: 1432-1335
    Schlagwort(e): Key words Colorectal neoplasms ; Apoptosis ; Chemosensitivity ; p53 gene
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose : The p53 gene is considered one of the most important in the control of apoptosis, and its mutations have a close relationship with chemosensitivity. The aim of this work was to investigate the role of p53 in the apoptosis of colorectal cancer cells in vitro, induced by 5-fluorouracil (5-FU) and hydroxy-camptothecin (HCPT). Methods : A total of 39 colorectal cancer samples from patients were treated in vitro with 5-FU (10 μg/ml), 5-FU (10 μg/ml) + leucovorin (5 μg/ml), HCPT (0.1 μg/ml) and HCPT (0.1 μg/ml) + Salvia mitorrhiza (6 μl), using an in situ terminal deoxynucleotidyltransferase assay to detect chemosensitivity. p53 gene mutations from tumor DNA were detected, after amplification by the polymerase chain reaction of exons 5–8, by non-radioactive single-strand conformation polymorphism. Results : p53 gene mutations were observed in 43.6% (17/39) of colorectal carcinomas, when the terminal deoxynucleotidyltransferase assay was used to detect the tumor apoptotic rate. Cells with mutated p53 had lower chemosensitivity than those without (p 〈 0.01). Conclusion : Routine assessment of p53 status may be helpful in selecting patients with the wild-type p53 gene, who have a predictably better response to chemotherapy.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Publikationsdatum: 2021-05-19
    Beschreibung: Taiwan Island is at the joint of Eurasian Continent and Pacific Plate, under threatening of typhoons and northeasterly strong winds. Consequently, enormous human lives and properties are lost every year. It is necessary to develop a coastal sea-state monitoring system. This paper introduces the coastal sea-state monitoring system (CSMS) along Taiwan coast. The COMC (Coastal Ocean Monitoring Center in National Cheng Kung University) built the Taiwan coastal sea-state monitoring system, which is modern and self-sufficient, consisting of data buoy, pile station, tide station, coastal weather station, and radar monitoring station. To assure the data quality, Data Quality Check Procedure (DQCP) and Standard Operation Procedure (SOP) were developed by the COMC. In further data analysis and data implementation of the observation, this paper also introduces some new methods that make the data with much more promising uses. These methods include empirical mode decomposition (EMD) used for the analysis of storm surge water level, wavelet transform used for the analysis of wave characteristics from nearshore X-band radar images, and data assimilation technique applied in wave nowcast operation. The coastal sea-state monitoring system has a great potential in providing ocean information to serve the society.
    Beschreibung: Published
    Schlagwort(e): Coastal sea-state monitoring ; Moored buoy ; Wave monitoring of radar technique ; EMD ; Wavelet transform ; Data assimilation
    Repository-Name: AquaDocs
    Materialart: Journal Contribution , Not Known
    Format: pp.42-56
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...