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  • 1
    Electronic Resource
    Electronic Resource
    Genetic variability and characterization of non-structural region 5 of hepatitis C virus genome from Chinese patients (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 62-72 
    Details
    ISSN: 1435-5922
    Keywords: Key words: hepatitis C virus ; nonstructural region 5 ; sequence analysis ; China
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Sequence variation in the putative nonstructural region 5b (NS5b) of hepatitis C virus (HCV) was analyzed in China. Complementary DNA fragments from sera of 49 Chinese patients were amplified by polymerase chain reaction (PCR) and the products were cloned and sequenced. Based on the comparison in NS5b of 33 clones of genotype 1b and 16 clones of genotype 2a, Chinese isolates of HCV belong to the same subtype as HCV-J, and HC-J6 from Japan. There does exist, however, some heterogeneity in the primary structure of the nucleotide acid. Higher homology was found among Chinese isolates than among Chinese isolates and Japanese isolates. Furthermore, among Chinese isolates, we found some conserved nucleotide acid positions different from those of Japanese isolates. Comparison of average homology among the 33 clones of genotype 1b and the 16 clones of genotype 2a indicated that the average homology among genotype 2a was lower than that among genotype 1b. In addition, a deletion of three nucleotide acids and a frame-shift, resulting in the introduction of an in-frame stop codon, were first observed in the NS5b region. These results indicated geographical differences in the distribution of individual HCV isolates, and the existence of a local variant in the same subtype. Our findings also suggested the need for further study on the sequence of genotype 2a, to improve diagnosis and help to advance the development of a vaccine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050046
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  • 2
    Electronic Resource
    Electronic Resource
    Impact-Induced delamination in [05, 905, 05] carbon fiber/polyetheretherketone composite laminates (1991)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 31 (1991), S. 1301-1309 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: This paper reports both experimental and numerical investigations on delamination mechanisms in [05, 905, 05] carbon fiber(CF)/poly(etheretherketone) (PEEK) laminate subjected to low-velocity impact. It was found that the CF/PEEK composite exhibits the same damage mechanisms as epoxy-based composites, but superior delamination resistance. For the crossply laminate, the impact delamination results from a Mode II interlaminar fracture process, and a close association exists between the interlaminar shear stress field and the delamination growth. The prediction of impact-induced delamination sizes is discussed.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760311804
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    Paper (German National Licenses)
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