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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 46 (1980), S. 313-317 
    ISSN: 1432-0738
    Keywords: Heme metabolism ; Liver ; Benzene ; Gasoline ; Kerosene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract δ-Aminolevulinic acid (ALA) synthetase, δ-ALA dehydratase and heme oxygenase activities were studied in the liver of albino rats, 3 and 20 h after i.p. administration of benzene, gasoline, and kerosene. δ-ALA synthetase activity was increased markedly after benzene administration, while gasoline and kerosene treated groups showed decreased enzyme activity. Inhibition of δ-ALA dehydratase activity was observed in all three groups, but heme oxygenase activity was unchanged.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0738
    Keywords: Benzene ; Bleomycin ; Low molecular weight iron ; Lipid peroxidation ; Superoxide radical ; Myelotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An accumulation of low molecular weight (LMW) bleomycin detectable iron in the bone marrow was observed after administration of benzene (IP 0.5 ml/kg, daily) for 5 and 10 days in female albino rats. However, this LMW iron was not detectable in the bone marrow of rats from the control group. Studies of bone marrow fractionation showed that the maximum accumulation of this LMW iron was in the mitochondrial fraction. An increase in the activity of superoxide dismutase and lipid peroxidation was also noticed in the benzene exposed groups.
    Type of Medium: Electronic Resource
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