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  • 1
    Digitale Medien
    Digitale Medien
    Metabolism and autoradiographic distribution of Δ8- and Δ9 tetrahydrocannabinol in some organs of the monkey callithrix jacchus (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 287 (1975), S. 219-225 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Δ8- and Δ9-Tetrahydrocannabinol ; Monkey ; Organ Distribution ; Autoradiography ; Metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Metabolism and autoradiographic distribution of the two isomeric tetrahydrocannabinols, (2,4-14C)-Δ8-THC and (2,4-14C)-Δ9-THC), were studied in the marmoset Callithrix jacchus. Of the two cannabinoids, Δ8-THC had a slower initial rate of biotransformation to the psychopharmacologically more potent 11-hydroxylated metabolite. This may explain the minor psychopharmacological activity of the Δ8-isomer. In glandular tissues an accumulation of unchanged Δ9-THC was observed. Autoradiography revealed characteristic label distributions in some organs 30 min after the administration of the drugs. This labelling pattern was found to be changed after a 6-hr incorporation period. The autoradiographic distribution of Δ8- and Δ9-THC appeared to be identical.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00510453
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Comparative autoradiographic and metabolic study of Δ 8- and Δ 9-Tetrahydrocannabinol in the brain of the marmoset Callithrix jacchus (1976)
    Springer
    Psychopharmacology 47 (1976), S. 53-58 
    Details
    ISSN: 1432-2072
    Schlagwort(e): 14C-Tetrahydrocannabinol ; Monkey ; Brain ; Autoradiography ; Metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The label distribution in the brain of the marmoset Callithrix jacchus following intravenous application of radioactively labeled Δ 8-tetrahydrocannabinol (Δ 8-THC) and Δ 9-THC is investigated by autoradiographic technique. Accumulations of label are observed in nuclei concerned with motor function, in the optic and acoustic pathways, and a few other structures. Of the two hydroxylated isomeres which were shown to be equally psychoactive the brain concentration of 11-OH-Δ 9-THC was found to be about 3 times higher as compared with 11-OH-Δ 8-THC, which may explain whyΔ 9-THC is more potent than Δ 8-THC. More than 90% of the radioactivity found in the brain can be attributed to the THCs and their 11-hydroxylated isomeres. Polar metabolites are almost completely absent from the brain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00428701
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Autoradiographische Untersuchungen zur Verteilung von Mescalin und dessen Einfluß auf die zentrale Erregung bei Mäusen (1969)
    Springer
    Psychopharmacology 16 (1969), S. 183-200 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Mescaline ; Autoradiography ; Topographic Distribution ; Mice ; Motility
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary After the injection of radioactive mescaline into mice the distribution of radioactivity was studied in different organs with biochemical and autoradiographic techniques. The half-life time of mescaline in the brain of mice was found to be about 55 min. One hour after injection, the highest level of radioactivity was found in thesoma rich areas of the cortex and of the brainstem. At this time the choroid plexus contained the highest amount of radioactivity within the brain. Six hours after the mescaline injection the radioactive material was concentrated more in the hippocampus compared with other areas of grey matter, whereas the plexus was nearly free of radioactivity. Motility increased parallel with the enrichment of the radioactivity in the cornu ammonis. Within the retina the layers with myelinated fibers were more radioactive than those containing the perikarya. A marked storage of radioactive material in the perikarya of the spinal ganglia was also observed. In the bone-marrow and in other reticulo-endothelial structures a high concentration of radioactivity was also found. In the liver the radioactivity was accumulated in the bile ducts and around the central veins. These autoradiograms were similar to the pictures which are obtained from Kupffer's cells by injection of Chinese ink. The adrenal medulla and the isles of Langerhans in the pancreas were also marked selectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02456044
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