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  • 1
    Electronic Resource
    Electronic Resource
    Ontogeny of the androgen receptor in rat ventral prostate during sexual development (1987)
    Springer
    Research in experimental medicine 187 (1987), S. 287-294 
    Details
    ISSN: 1433-8580
    Keywords: Androgen receptor ; Dihydrotestosterone ; Ontogeny ; Puberty ; Prostate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concentrations of cytosolic androgen receptor, DNA and soluble protein, contents of DHT, and in-vivo uptake of3H-DHT were measured in rat ventral prostates at 5-day intervals during sexual development. Regarding prostate weight two phases of growth were noted being separated by a period of stagnation from Day 40 to 45. Cytosolic androgen receptor, particle-bound DHT, and uptake of3H-DHT into the 100,000-g sediment showed a clear pattern: a maximum in the prepubertal animal at age Day 20, a minimum at age Day 30 (4 days after the early pubertal rise of LH, testosterone, and DHT) followed by a second maximum on Day 55 (2 days before the beginning of fertility), and a second minimum in the young mature animal on Day 70. An intermediate peak seen at age Day 37 was not significant. Neither the time-dependent profile of the cytosolic androgen receptor nor the contents and in vivo uptake of DHT were correlated to concentrations of circulating gonadotrophins, growth hormone, and sex-steroids measured during puberty in the same strain of animals. Therefore, the regulating mechanism remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852054
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  • 2
    Electronic Resource
    Electronic Resource
    Seasonal and diurnal changes of prostatic androgen receptor and circulating testosterone in young mature rats (1988)
    Springer
    Research in experimental medicine 188 (1988), S. 451-462 
    Details
    ISSN: 1433-8580
    Keywords: Androgen receptor ; Diurnal rhythm ; Rat ventral prostate ; Seasonal rhythm ; Testosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Low- and high-salt (600 mM KCl) extractable androgen receptors were measured in the ventral prostate lobes of 70-day-old rats which were housed in constant environmental conditions (22 ± 2°C, 65 ± 5% air humidity, light 6.00 h–18.00 h). Seasonal variations were observed during 2 years, exhibiting elevations in late summer and autumn and depressions in late winter and spring time. These fluctuations were superposed by steep changes from month to month. The maximum and minimum values of the low- and high-salt extractable receptors differed within 1 year by a factor 8.5 and 2.4, respectively. Both receptor fractions showed a diurnal rhythm as measured during 1 day in January with maximal concentrations at 9.00 h (low-salt: median = 1 308 fmol/mg DNA) and minimal values at 18.00 (424) and 24.00 (230). The electrophoretic mobility in agar gel of pH 8.2 also showed a diurnal variation with maximal values at 18.00 h in either receptor fraction. Neither the seasonal nor the diurnal variations were correlated to the corresponding rhythms of serum testosterone concentrations. As steroid receptors may be regulated by neural transmission, in a final experiment the parasympathic innervation of the prostate was blocked by infiltrating the plexus pelvicus with a local anesthetic drug. One hour later, the total receptor concentration was not changed, while the ratio of low- to high-salt extractable receptors and the electrophoretic mobility of both fractions were elevated as compared to the control animals. This finding indicates that peripheral neural transmission rather than circulating testosterone may be involved in the regulation of androgen receptors in rat ventral prostate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852003
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
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