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  • 1
    ISSN: 1435-5922
    Keywords: Key words: hepatitis C virus ; nonstructural region 5 ; sequence analysis ; China
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Sequence variation in the putative nonstructural region 5b (NS5b) of hepatitis C virus (HCV) was analyzed in China. Complementary DNA fragments from sera of 49 Chinese patients were amplified by polymerase chain reaction (PCR) and the products were cloned and sequenced. Based on the comparison in NS5b of 33 clones of genotype 1b and 16 clones of genotype 2a, Chinese isolates of HCV belong to the same subtype as HCV-J, and HC-J6 from Japan. There does exist, however, some heterogeneity in the primary structure of the nucleotide acid. Higher homology was found among Chinese isolates than among Chinese isolates and Japanese isolates. Furthermore, among Chinese isolates, we found some conserved nucleotide acid positions different from those of Japanese isolates. Comparison of average homology among the 33 clones of genotype 1b and the 16 clones of genotype 2a indicated that the average homology among genotype 2a was lower than that among genotype 1b. In addition, a deletion of three nucleotide acids and a frame-shift, resulting in the introduction of an in-frame stop codon, were first observed in the NS5b region. These results indicated geographical differences in the distribution of individual HCV isolates, and the existence of a local variant in the same subtype. Our findings also suggested the need for further study on the sequence of genotype 2a, to improve diagnosis and help to advance the development of a vaccine.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2021-05-19
    Description: Taiwan Island is at the joint of Eurasian Continent and Pacific Plate, under threatening of typhoons and northeasterly strong winds. Consequently, enormous human lives and properties are lost every year. It is necessary to develop a coastal sea-state monitoring system. This paper introduces the coastal sea-state monitoring system (CSMS) along Taiwan coast. The COMC (Coastal Ocean Monitoring Center in National Cheng Kung University) built the Taiwan coastal sea-state monitoring system, which is modern and self-sufficient, consisting of data buoy, pile station, tide station, coastal weather station, and radar monitoring station. To assure the data quality, Data Quality Check Procedure (DQCP) and Standard Operation Procedure (SOP) were developed by the COMC. In further data analysis and data implementation of the observation, this paper also introduces some new methods that make the data with much more promising uses. These methods include empirical mode decomposition (EMD) used for the analysis of storm surge water level, wavelet transform used for the analysis of wave characteristics from nearshore X-band radar images, and data assimilation technique applied in wave nowcast operation. The coastal sea-state monitoring system has a great potential in providing ocean information to serve the society.
    Description: Published
    Keywords: Mooring buoys ; Acoustic waves ; Monitoring
    Repository Name: AquaDocs
    Type: Journal Contribution , Non-Refereed , Article
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