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  • 1
    Electronic Resource
    Electronic Resource
    Radiation crosslinked poly(vinylmethylsiloxane) for levonorgestrel delivery system (1988)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 26 (1988), S. 195-199 
    Details
    ISSN: 0887-6258
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1988.140260405
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Thermal and mechanical properties of phenolphthalein polyethersulfone/poly(phenylene sulfide) blends (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 55 (1995), S. 633-639 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The thermal and mechanical properties of phenolphthalein polyethersulfone/poly(phenylene sulfide) (PES-C/PPS) blends were studied using a differential scanning calorimeter, a dynamic mechanical analyzer, and mechanical characterization. The morphologies of fracture surfaces were observed by scanning electron microscopy. The blends are multiphase systems with strong interaction between the two phases. It is of interest that, although the strength and ductility of PPS are lower than those of PES-C, the addition of PPS can improve markedly the impact strength of PES-C without changing its higher strength. The PPS can also act as a flow aid for PES-C. © 1995 John Wiley & Sons, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070550411
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of metal salts on poly(DL-lactide-co-glycolide) polymer hydrolysis (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 34 (1997), S. 531-538 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The effects of encapsulated metal salts on poly(DL-lactide-co-glycolide) (PLGA) water uptake and degradation properties were investigated in this work. Salts of varying aqueous solubility characteristics were incorporated into PLGA films either as particles or by codissolution in polymer solutions. Polymer films were characterized with respect to the kinetics of water uptake, morphology changes, degradation, and weight loss after hydration. It was found that these properties are strongly influenced by the presence and nature of encapsulated salts. Effects range from minor changes in water uptake profile with no significant difference in degradation kinetics to major alterations in water uptake kinetics together with a several-fold decrease in the polymer degradation rate. Possible mechanistic explanations for the observed effects are discussed. © 1997 John Wiley & Sons, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 4
    Electronic Resource
    Electronic Resource
    Eigenproperties of large-scale structures by finite element partitioning and homotopy continuation (1989)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 28 (1989), S. 2113-2122 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Finite element partitioning (or substructuring) is employed to estimate the eigenproperties of large-scale structural systems. A homotopy equation is constructed and its solutions are characterized by a number of curves which connect the eigensolutions of the partitions with those of the complete system. A step-by-step tracing procedure is developed to follow these curves. At each step, prediction and correction are performed. The Rayleigh-Ritz procedure and the conjugate gradient method are used as predictor and corrector, respectively. Compared with the sole use of either the Rayleigh-Ritz or gradient methods, the proposed method is more reliable and more efficient for large-scale problems. Numerical implementation is well suited for supercomputers.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620280909
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  • 5
    Electronic Resource
    Electronic Resource
    Multiple scale finite element methods (1991)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 32 (1991), S. 969-990 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: New temporal and spatial discretization methods are developed for multiple scale structural dynamic problems. The concept of fast and slow time scales is introduced for the temporal discretization. The required time step is shown to be dependent only on the slow time scale, and therefore, large time steps can be used for high frequency problems. To satisfy the spatial counterpart of the requirement on time step constraint, finite-spectral elements and finite wave elements are developed. Finite-spectral element methods combine the usual finite elements with the fast convergent spectral functions to obtain a faster convergence rate; whereas, finite wave elements are developed in parallel to the temporal shifting technique. Therefore, the spatial resolution is increased substantially. These methods are especially applicable to structural acoustics and linear space structures. Numerical examples are presented to illustrate the effectiveness of these methods.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620320504
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  • 6
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    Insulin induces C2C12 cell proliferation and apoptosis through regulation of cyclin D1 and BAD expression (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-06-25
    Description: Insulin is a secreted peptide hormone identified in human pancreas to promote glucose utilization. Insulin has been observed to induce cell proliferation and myogenesis in C2C12 cells. The precise mechanisms underlying the proliferation of C2C12 cells induced by insulin remain unclear. In this study, we observed for the first time that 10nM insulin treatment promotes C2C12 cell proliferation. Additionally, 50 nM and 100nM insulin treatment induces C2C12 cell apoptosis. By utilizing real-time PCR and Western blotting analysis, we found that the mRNA levels of cyclinD1 and BAD are induced upon 10nM and 50nM/100nM insulin treatment respectively. The similar results were observed in C2C12 cells expressing GATA-6 or PPARα. Our results identify for the first time the downstream targets of insulin, cyclin D1 and BAD, elucidate a new molecular mechanism of insulin in promoting cell proliferation and apoptosis. J. Cell. Biochem. © 2013 Wiley Periodicals, Inc.
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley-Blackwell
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  • 7
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    Loss of BRM Expression is a Frequently Observed Event in Poorly Differentiated Clear Cell Renal Cell Carcinoma (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-11-27
    Description: Aims The aim of this study was to examine the status of BRM, a key SWI/SNF complex subunit, in clear cell renal cell carcinomas (RCC), and to analysis the histopathology, immunophenotype, molecular features, and prognosis of the BRM-negative cases. Methods and results We identified 19 cases of grade 4 tumors lacking of BRM expression among 625 clear cell RCC. All 19 cases exhibited poorly differentiated features, 13 showed pure poorly differentiated morphology while 6 were composite tumors mixed with typical low grade component. Besides negative BRM expression, the immunophenotype of these cases was similar to clear cell RCC. VHL gene mutations were identified in 9/19 patients (47%). Chromosome 3p deletion was detected in 11/13 poorly differentiated RCCs and both areas of 5/5 composite tumors. All poorly differentiated tumor areas showed polysomy of chromosome 3. No losses or gains of chromosome 3 were observed in low grade tumor areas of 5/5 composite RCCs. Conclusions We have shown that a loss of BRM expression is a common feature among poorly differentiated tumors in clear cell RCCs. We hypothesize that loss of BRM expression is involved in tumor dedifferentiation in clear cell RCCs and may play an important role during tumor progression. This article is protected by copyright. All rights reserved.
    Print ISSN: 0309-0167
    Electronic ISSN: 1365-2559
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 8
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    Lanostane Triterpenes from Ceriporia lacerate HS-ZJUT-C13A, a Fungal Endophyte of Huperzia serrata (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-11-16
    Description: Two new lanostane triterpenes, 3 β -acetoxy-15 α -hydroxylanosta-8,24-dien-21-oic acid ( 1 ) and 3 β -acetoxylanosta-7,9(11),24-trien-21-oic acid ( 2 ), along with the four known analogs, 3 – 6 , were isolated from the culture broth of Ceriporia lacerate HS-ZJUT-C13A, a fungal endophyte residing in the stems of the traditional Chinese herb Huperzia serrata. The structures of the new compounds 1 and 2 were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D- and 2D-NMR techniques. To the best of our knowledge, this is the first report on triterpene metabolites from the genus Ceriporia.
    Print ISSN: 0018-019X
    Electronic ISSN: 1522-2675
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 9
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    Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with HBV infection by promoting Th17 cell recruitment (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-10-30
    Description: It is well established that interleukin (IL)-22 has hepatoprotective and anti-fibrotic functions in acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis (LC) remains obscure. In the current study, we demonstrated that expression of numerous IL-22 pathway-associated genes was significantly upregulated in hepatitis B virus (HBV)-infected liver tissues compared with normal controls through microarray analysis. In agreement with these findings, liver-infiltrating IL-22 + cells were largely increased in HBV-infected patients with LC compared with those without LC or healthy subjects, and were positively associated with liver fibrosis staging scores. Immunohistochemistry and flow cytometric analyses revealed that IL-22 was produced by multiple intrahepatic immune cells, and preferentially by Th17 cells in LC patients. In a HBV transgenic mouse model of T cell-mediated chronic liver inflammation/fibrosis, blockade of IL-22 attenuated hepatic expression of CXCL10 and CCL20, and subsequently reduced Th17 recruitment and liver inflammation/fibrosis progression. In vitro treatment with IL-22 stimulated hepatic stellate cells (HSCs) to secret several chemokines and subsequently promoted Th17 cell chemotaxis. Blocking CXCR3 or CCL20 reduced Th17 cell chemotaxis by IL-22-treated HSCs. Conclusions : Our findings suggest that IL-22 plays a pathological role in exacerbating chronic liver inflammation and fibrosis by recruiting hepatic Th17 cells in HBV infected patients and HBV transgenic mice. (H epatology 2013;)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The American Association for the Study of Liver Diseases.
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  • 10
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    Combined value of susceptibility-weighted and perfusion-weighted imaging in assessing WHO grade for brain astrocytomas (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-10-30
    Description: Purpose To assess the value of combining susceptibility-weighted imaging (SWI) and dynamic susceptibility-weighted contrast-enhanced (DSC) perfusion-weighted MRI (PWI) in assessing World Health Organization (WHO) grade for brain astrocytoma. Materials and Methods A total of 94 patients with pathologically confirmed astrocytomas underwent SWI and DSC scans. The evaluation included intratumoral susceptibility signal intensity (ITSS) and relative cerebral blood volume (rCBV) max. The receiver operating characteristic curve (ROC) was used to assess the efficacy of combining two sequences in astrocytoma grading. Results ITSS within astrocytomas showed significant correlations with rCBV max (r = 0.72; P 〈 0.01) and with tumor grades (r = 0.92; P 〈 0.01), and there was also a significant correlation between rCBV and tumor grade (r = 0.77; P 〈 0.001). The area under the ROC, SWI, PWI, SWI, and PWI, in differentiation of the grades II and III astrocytomas were 0.995, 0.942, and 1.000, respectively; identifying grades III and IV were 0.773, 0.919, and 0.978, respectively; and identifying high and low-grade astrocytomas were 0.999, 0.992, 1.000, respectively. Conclusion ITSS was useful for assessing the WHO tumor grade in this cohort of patients with astrocytoma. The combination of SWI and PWI may improve the diagnostic accuracy of astrocytoma grading. J. Magn. Reson. Imaging 2013; . © 2013 Wiley Periodicals, Inc .
    Print ISSN: 1053-1807
    Electronic ISSN: 1522-2586
    Topics: Medicine
    Published by Wiley-Blackwell
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