GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Hydrogenation of m-xylene catalyzed by a silica-supported polysilazane-platinum complex (1996)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 7 (1996), S. 79-83 
    Details
    ISSN: 1042-7147
    Keywords: hydrogenation ; m-xylene ; polysilazane ; stereochemistry ; platinum complex ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A new kind of inorganic polymer, silica-supported polysilazane (Si-N), and its platinum complex (Si-N-Pt) were prepared and characterized by X-ray photoelectron spectroscopy. It was found that Si-N-Pt can catalyze hydrogenation of m-xylene under mild conditions (30-50°C, 1 atm). The products of the reaction were cis- and trans-1,3-dimethylcyclohexane. The formation of trans-1,3-dimethylcyclohexane may be adequately explained according to the “roll-over” model. The stereoselectivity was influenced by temperature and catalyst concentration, the proportion of the cis isomer decreasing with an increase in each of the two factors. The effects of other reaction parameters, such as the N/Pt mole ratio in the complex, solvents and reaction time, etc., on the hydrogenation of m-xylene were also studied. The Si-N-Pt catalyst is very stable in reaction and turnover numbers amount to 520 in 70 hr.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
  • 2
    Electronic Resource
    Electronic Resource
    Analysis of substrate protection of an immobilized glucose isomerase reactor (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 41 (1993), S. 451-458 
    Details
    ISSN: 0006-3592
    Keywords: immobilized glucose isomerase ; substrate protection ; reactor analysis ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The effect of substrate protection on enzyme deactivation was studied in a differential bed and a packed bed reactor using a commercial immobilized glucose isomerase (Swetase, Nagase Co.). Experimental data obtained from differential bed reactor were analyzed based on Briggs-Haldane kinetics in which enzyme deactivation accompanying the protection of substrate was considered. The deactivation constant of the enzyme-substrate complex was found to be about half of that of the free enzyme. The mathematical analysis describing the performance of a packed bed reactor under the considerations of the effects of substrate protection, diffusion resistance, and enzyme deactivation was studied. The system equations for the packed bed reactor were solved using an orthogonal collocation method. The presence of substrate protection and the diffusion effect within the enzyme particles resulted in an axial variation of effectiveness factor, ηD, along the length of the packed bed. The axial distribution profile of ηD was found to be dependent on the operation temperature, Based on the effect of substrate protection, a better substrate feed policy could be theoretically found for promoting productivity in long-term operation. © 1993 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260410408
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of thermal history on crystallization behavior of polyetheretherketone studied by differential scanning calorimetry (1988)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 164 (1988), S. 21-34 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Das Kristallisationsverhalten von Polyetheretherketon (PEEK) wurde mit Hilfe der Differentialkalorimetrie (DSC) untersucht. Mit der Erhöhung der Kristallinität verschiebt sich die Glastemperatur zu höheren Temperaturen. Hitzebehandeltes PEEK zeigt Doppelpeaks in der DSC-Kurve, was für PEEK charakteristisch ist. Diese Doppelpeaks werden, je nach den Bedingungen der Hitzebehandlung, durch die Bildung unvollständiger Kristallstrukturen hervorgerufen.
    Notes: The crystallization behavior of polyetheretherketone (PEEK) was investigated by differential scanning calorimetry (DSC). The glass transition temperature of PEEK shifts to higher temperatures with an increase in crystallinity. Heat-treated PEEK showed double peaks in their DSC curves, which is a characteristic phenomenon of PEEK. These double peaks were caused by the formation of incomplete crystal structures according to the conditions of heat-treatment.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1988.051640102
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    facet.materialart.
    Unknown
    MET amplification is not rare and predicts unfavorable clinical outcomes in patients with recurrent/metastatic gastric cancer after chemotherapy (2013)
    Wiley-Blackwell
    In: Cancer
    Details
    Publication Date: 2013-11-06
    Description: BACKGROUND Several large studies have reported an extremely low incidence of MET gene amplification (GA) in patients with radically resected gastric cancer. This study was conducted to evaluate the prevalence and prognostic role of MET in patients with recurrent/metastatic gastric cancer who received chemotherapy. METHODS MET GA and protein expression of recurrent/metastatic gastric cancer samples were evaluated by fluorescence in situ hybridization and immunohistochemistry (IHC), respectively. RESULTS This retrospective study included 232 patients with recurrent/metastatic gastric cancer. MET GA and strong protein expression (IHC3+) were observed in 8.3% (19 of 230 samples) and 9.6% (22 of 229 samples) of samples, respectively. A significant correlation was observed between MET GA and protein expression (r = 0.378; P  〈 .001). MET GA was correlated with poor performance status ( P  〈 .001) and poorly differentiated tumors ( P  = .0015). Both MET GA and IHC 3+ expression were associated with a substantially shorter median overall survival (OS) and progression-free survival (PFS). The median OS and PFS for patients with MET GA versus those without MET GA were 5.7 months versus 15.5 months ( P  〈 .001) and 3.6 months versus 6.9 months ( P  〈 .001), respectively. The median OS and PFS for patients with MET IHC 3+ expression versus IHC 0 to 2+ expression were 6.3 months versus 15.1 months ( P  〈 .001) and 3.6 months versus 7.0 months ( P  〈 .001), respectively. CONCLUSIONS In patients with recurrent/metastatic gastric cancer, MET amplification and strong protein expression are not rare and appear to be significantly associated with unfavorable clinical outcomes. Cancer 2013; . © 2013 American Cancer Society .
    Print ISSN: 0008-543X
    Electronic ISSN: 1097-0142
    Topics: Biology , Medicine
    Published by Wiley-Blackwell on behalf of The American Cancer Society.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-12-19
    Description: Tumor-stroma interactions contribute greatly to intratumoral estrogen biosynthesis in endometrial carcinoma, but the mechanisms involved remain largely unknown. Previous study demonstrated that intratumoral aromatase upregulation in stromal cells participated in this process, but the specific aromatase-regulators have not been reported. In the present study, we found that aromatase expression in intratumoral stroma, but not in tumor epithelium, correlated positively with interleukin (IL)-6 expression in cancer epithelial cells by immunohistochemistry, which was confirmed using laser capture microdissection/ real-time reverse transcription-PCR. With stimulation by exogenous IL-6, aromarase expression was increased in stromal cells not but not in cancer cells. Aromatase mRNA levels in endometrial cancer cells were not influenced by cocultivation with intratumoral stromal cells. When cocultured with 17β-estradiol (E 2 )-treated cancer cells, aromatase mRNA in stromal cells was significantly elevated and increased IL-6 protein levels were detected in E 2 -treated culture medium. Next, we demonstrated that E 2 -induced IL-6 production was through cooperation between estrogen receptor α and nuclear factor-kappa B. Furthermore, an IL-6 receptor blocking antibody could attenuate the upregulation of aromatase expression in stromal cells and the E 2 concentration in coculture systems of cancer and stromal cells. The results were confirmed by an orthotopic nude endometrial carcinoma model in vivo . These studies elucidated the activation of a positive feedback loop, that is, IL-6 stimulated by E 2 in endometrial cancer cells induced aromatase expression in stromal cells, promoting enhanced intratumoral E 2 synthesis. Blocking of this tumor-stroma interaction may be a therapeutic strategy to overcome in situ estrogen biosynthesis in endometrial carcinoma. © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    An engineered microorganism can simultaneously detoxify cadmium, chlorpyrifos, and γ-hexachlorocyclohexane (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-12-10
    Description: Many ecosystems are currently co-contaminated with heavy metals such as cadmium (Cd 2+ ) and pesticides such as chlorpyrifos (CP) and γ-hexachlorocyclohexane (γ-HCH). A feasible approach to remediate the combined pollution of heavy metals and pesticides is the use of γ-HCH degrading bacteria endowed with CP hydrolysis and heavy metal biosorption capabilities. In this work, a recombinant microorganism capable of simultaneously detoxifying Cd 2+ , CP, and γ-HCH was constructed by display of synthetic phytochelatins (EC20) and methyl parathion hydrolase (MPH) fusion protein on the cell surface of the γ-HCH degrading Sphingobium japonicum UT26 using the truncated ice nucleation protein (INPNC) as an anchoring motif. The surface localization of INPNC–EC20–MPH was verified by cell fractionation, Western blot analysis, immunofluorescence microscopy, and proteinase accessibility experiment. Expression of EC20 on the cell surface not only improved Cd 2+ binding but also alleviated the cellular toxicity of Cd 2+ . As expected, the rates of CP and γ-HCH degradation were reduced in the presence of Cd 2+ for cells without EC20 expression. However, expression of EC20 (higher Cd 2+ accumulation) significantly restored the levels of CP and γ-HCH degradation. These results demonstrated that surface display of EC20 enhanced not only Cd 2+ accumulation but also protected the recombinant strain against the toxic effects of Cd 2+ on CP and γ-HCH degradation.
    Print ISSN: 0233-111X
    Electronic ISSN: 1521-4028
    Topics: Biology
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Tuning Cadmium Coordination Architectures by Phenylenediacetate Position Isomers and 1,4-Bis(benzimidazol-1-ylmethyl)benzene (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-10-20
    Description: Three position isomers 1,2-, 1,3-, 1,4-phenylenediacetate and 1,4-bis(benzimidazol-1-ylmethyl)benzene (bmb) were used to assembly cadmium(II) coordination polymers, [Cd(bmb)(1,2-phda)] n ( 1 ), {Cd(bmb)(1,3-phda)] · 0.5(bmb)} n ( 2 ), and [Cd(bmb) 0.5 (1,4-phda)] n ( 3 ), which are characterized by elemental analyses, infrared spectra (IR), thermogravimetric analysis (TGA) and single-crystal X-ray diffraction. Single crystal structure analysis shows that complex 1 is a two-dimensional wave-like layer network. Complex 2 features a (3,5)-connected three-dimensional frameworks with (4 2 .6)(4 2 .6 5 .8 3 ) topology, whereas complex 3 shows a (4,4)-connected three-dimensional (4.6 4 .7)(4 2 .6 2 .8 2 ) topology. The structural versatility reveals that a significant structure-directing effect of the position of the acetate groups during self-assembly of these coordination polymers. Moreover, luminescent properties and thermal stabilities of three complexes were discussed in detail.
    Print ISSN: 0044-2313
    Electronic ISSN: 1521-3749
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Cyanide-Bridged Tetranuclear REIII2FeIII2 (RE = Y, Tb, Dy) Molecular Squares with 2, 2′:6′,2′′-Terpyridine as a Capping Ligand (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-03-05
    Description: Self-assembly reaction between hydrated rare-earth ( RE ) nitrates RE (NO 3 ) 3 · 6H 2 O with K 3 Fe(CN) 6 in H 2 O/DMF solution by employing the tridentate ligand 2, 2′:6′,2′′-terpyridine (terpy) as a capping ligand has yielded three cyanide-bridged compounds [ RE (terpy)(DMF)(H 2 O) 2 ][Fe(CN) 6 ] · 6H 2 O [ RE = Y ( 1 ), Tb ( 2 ), Dy ( 3 )]. FT-IR spectra confirmed the presence of terpy ligands and cyanide groups in compounds 1 – 3 . Single-crystal X-ray structural analysis indicated that these compounds are isomorphous and adopt neutral [ RE 2 Fe 2 ] molecular squares, which are further linked through hydrogen bonding interactions to generate a three-dimensional supramolecular network. Magnetic susceptibility measurements revealed that significant single ion magnetic anisotropy dominates the properties of these compounds.
    Print ISSN: 0044-2313
    Electronic ISSN: 1521-3749
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Beneficial roles of melanoma cell adhesion molecule in spinal cord transection recovery in adult zebrafish (2016)
    Wiley-Blackwell
    Details
    Publication Date: 2016-06-19
    Description: Melanoma cell adhesion molecule (MCAM) is a multifunctional protein involved in miscellaneous processes, including development and tumor angiogenesis. Here, spinal cord transection in adult zebrafish was used to investigate the effects of MCAM on spinal cord injury (SCI) and subsequent recovery. Expression of MCAM mRNA increased and co-localized with motoneurons in the spinal cord after SCI. With MCAM morpholino (MO) treatment, inhibition of MCAM retarded both axon regrowth and locomotor recovery in the spinal cord injured zebrafish. Further, MCAM mRNA expression was also observed in fli1a:EGFP transgenic zebrafish, which specifically show labeled blood vessels. Inhibition of MCAM down-regulated the expression of angiogenesis-related factors, such as VEGFR2, p-p38 and p-AKT, and the inflammatory factors TNF-α, IL-1β and IL-8. Taken together, these data suggest that MCAM may have a beneficial role in the recovery from SCI, via the promotion of neurogenesis and angiogenesis. This article is protected by copyright. All rights reserved.
    Print ISSN: 0022-3042
    Electronic ISSN: 1471-4159
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The International Society for Neurochemistry.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation (2015)
    Wiley-Blackwell
    In: Yeast
    Details
    Publication Date: 2015-07-15
    Description: 6-azauracil (6AU) inhibits enzymes in nucleoside synthesis and depletes intracellular GTP/UTP pool. Mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways exaggerate the growth defect of cells in the presence of 6AU. Thus, identification of mutations that render cells sensitive to 6AU will benefit the study on the basis of 6AU-sensitive phenotype. Here, we performed a genome-wide screen of a fission yeast deletion library. Out of 3235 single-gene deletions, 66 mutants displayed at least 50% drop of fitness in the presence of 6AU and 60 mutants were reported for the first time. 5 deletions showed synthetic decrease of fitness when combined with deletion of set3 + , which encodes a transcriptional regulator. Genes conferring tolerance to 6AU were enriched in various processes, especially in chromosome segregation. Accordingly, genes encoding subunits of CLRC complex and spindle pole body were overrepresented. Mutants were subjected to an in vivo transcript-length dependent reporter assay to assess the potential roles of deleted genes in transcriptional elongation. Same as the deletions known to affect elongation, nab2 Δ, nxt1 Δ, rhp18 Δ, SPAC24C9.08 Δ, clr3 Δ and ncs1 Δ set3 Δ mutants exhibited defects in expressing long transcript. New 6AU-sensitive mutants identified here will help to elucidate the mechanism of action of 6AU in the cells. Meanwhile, our study reveals novel genes potentially involved in transcriptional elongation and provides valuable targets for transcription study. This article is protected by copyright. All rights reserved.
    Print ISSN: 0749-503X
    Electronic ISSN: 1097-0061
    Topics: Biology
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...