GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 4 (1992), S. 205-215 
    ISSN: 0899-0042
    Keywords: cyclodextrins ; molecular mechanics ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A comparison of α-, β and γ-cyclodextrins in the solid state is made. Monomeric features analyzed include orientations of primary hydroxyl groups and pyran ring pucker. Macromolecular features examined include planarity of the oligomer, tilting of pyran rings, and, deviation from Cn symmetry where n = number of monomers. The mean values and standard deviations of these shape descriptors are given for cyclodextrins with and without guests embedded in their interiors. Molecular mechanics calculations using the MM2, AMBER, and CHARMM force fields show that most solid state cyclodextrins are trapped in high-energy conformations relative to the most stable forms found in this study. © 1992 Wiley-Liss, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 5 (1993), S. 51-57 
    ISSN: 0899-0042
    Keywords: molecular mechanic ; guest-host cyclodextrin complexes ; enantiodiscriminating forces ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A molecular mechanics investigation of R- vs. S-phenylethanol, R- vs. S-mandelic acid, R- vs. S-flurbiprofen, and R- vs. S-fenoprofen in their cyclodextrin crystal environments was undertaken. It was found that the dominant force responsible for guesthost complexation is the short-range London force; the enantiodiscriminating forces tend to be very small and are generally, but not always, dominated by long-range electrostatic contributions. Derivatized cyclodextrins are generally more enantiodiscriminating than native cyclodextrins, perhaps due to exterior rather than interior guest-host binding. © 1993 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 57 (1995), S. 655-665 
    ISSN: 0730-2312
    Keywords: sulfate uptake ; chromium(VI) uptake ; GSH ; GST ; catalase ; cytotoxicity ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Chromium(VI) resistant Chinese hamster ovary (CHO) cell lines were established in this study by exposing parental CHO-K1 cells to sequential increases in CrO3 concentration. The final concentration of CrO3 used for selection was 7 μM for Cr7 and 16 μM for Cr16 cells. Cr16-1 was a subclone derived from Cr16 cells. Next, these resistant cells were cultured in media without CrO3 for more than 6 months. The resistance of these cells to CrO3 was determined by colony-forming ability following a 24-h treatment. The LD50 of CrO3 for chromium(VI) resistant cells was at least 25-fold higher than that of the parental cells. The cellular growth rate, chromosome number, and the hprt mutation frequency of these chromium(VI) resistant cells were quite similar to their parental cells. The glutathione level, glutathione S-transferase, catalase activity, and metallothionine mRNA level in Cr7 and Cr16-1 cells were not significantly different from their parental cells. Furthermore, Cr16-1 cells were as sensitive as CHO-K1 cells to free-radical generating agents, including hydrogen peroxide, nickel chloride, and methanesulfonate methyl ester, and emetine, i.e., a protein synthesis inhibitor. The uptake of chromium(VI) and the remaining amount of this metal in these resistant and the parental cell lines were assayed by atomic absorption spectrophotometry. Experimental results indicated that a vastly smaller amount of CrO3 entered the resistant cell lines than their parental cells did. A comparison was made of the sulfate uptake abilities of CHO-K1 and chromium(VI) resistant cell lines. These results revealed that the uptake of sulfate anion was substantially reduced in Cr7 and Cr16-1 cells. Extracellular chloride reduced sulfate uptake in CHO-K1 but not in Cr16-1 cells. Therefore, the major causative for chromium(VI) resistance in these resistant cells could possibly be due to the defects in SO42-/C1- transport system for uptake chromium(VI).
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2015-10-06
    Description: Parrotia subaequalis (Hamamelidaceae) is a Tertiary relic species endemic in eastern China. We used inter-simple sequence repeat (ISSR) markers to access genetic diversity and population genetic structure in natural five populations of P. subaequalis . The levels of genetic diversity were higher at species level ( H  =   0.2031) but lower at population level ( H  =   0.1096). The higher genetic diversity at species levels might be attributed to the accumulation of distinctive genotypes which adapted to the different habitats after Quaternary glaciations. Meanwhile, founder effects on the early stage, and subsequent bottleneck of population regeneration due to its biological characteristics, environmental features, and human activities, seemed to explain the low population levels of genetic diversity. The hierarchical AMOVA revealed high levels (42.60%) of among-population genetic differentiation, which was in congruence with the high levels of Nei's genetic differentiation index ( G ST  = 0.4629) and limited gene flow ( N m  = 0.5801) among the studied populations. Mantel test showed a significant isolation-by-distance, indicating that geographic isolation has a significant effect on genetic structure in this species. Unweighted pair-group method with arithmetic average clustering, PCoA, and Bayesian analyses uniformly recovered groups that matched the geographical distribution of this species. In particular, our results suggest that Yangtze River has served as a natural barrier to gene flow between populations occurred on both riversides. Concerning the management of P. subaequalis , the high genetic differentiation among populations indicates that preserving all five natural populations in situ and collecting enough individuals from these populations for ex situ conservation are necessary. Parrotia subaequalis (Hamamelidaceae) is a Tertiary relic species endemic in eastern China. The levels of genetic diversity were higher at species level but lower at population level. UPGMA clustering, PCoA, and Bayesian analyses uniformly recovered groups that matched the geographical distribution of this species. In particular, our results suggest that Yangtze River has served as a natural barrier to gene flow between populations occurred on both riversides.
    Electronic ISSN: 2045-7758
    Topics: Biology
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2017-06-23
    Description: Purpose To evaluate the utility of the whole-lesion histogram apparent diffusion coefficient (ADC) for characterizing the heterogeneity of mucinous breast carcinoma (MBC) and to determine which ADC metrics may help to best differentiate subtypes of MBC. Materials and Methods This retrospective study involved 52 MBC patients, including 37 pure MBC (PMBC) and 15 mixed MBC (MMBC). The PMBC patients were subtyped into PMBC-A (20 cases) and PMBC-B (17 cases) groups. All patients underwent preoperative diffusion-weighted imaging (DWI) at 1.5T and the whole-lesion ADC assessments were generated. Histogram-derived ADC parameters were compared between PMBC vs. MMBC and PMBC-A vs. PMBC-B, and receiver operating characteristic (ROC) curve analysis was used to determine optimal histogram parameters for differentiating these groups. Results The PMBC group exhibited significantly higher ADC values for the mean ( P  = 0.004), 25 th ( P  = 0.004), 50 th ( P  = 0.004), 75 th ( P  = 0.006), and 90 th percentiles ( P  = 0.013) and skewness ( P  = 0.021) than did the MMBC group. The 25 th percentile of ADC values achieved the highest area under the curve (AUC) (0.792), with a cutoff value of 1.345 × 10 −3 mm 2 /s, in distinguishing PMBC and MMBC. The PMBC-A group showed significantly higher ADC values for the mean ( P  = 0.049), 25 th ( P  = 0.015), and 50 th ( P  = 0.026) percentiles and skewness ( P  = 0.004) than did the PMBC-B group. The 25 th percentile of the ADC cutoff value (1.476 × 10 −3 mm 2 /s) demonstrated the best AUC (0.837) among the ADC values for distinguishing PMBC-A and PMBC-B. Conclusion Whole-lesion ADC histogram analysis enables comprehensive evaluation of an MBC in its entirety and differentiating subtypes of MBC. Thus, it may be a helpful and supportive tool for conventional MRI. Level of Evidence : 4 Technical Efficacy Stage 2 J. Magn. Reson. Imaging 2017.
    Print ISSN: 1053-1807
    Electronic ISSN: 1522-2586
    Topics: Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2017-11-09
    Description: Geochronological, geochemical, and isotopic studies were carried out on the Paleoproterozoic granitic rocks, widely exposed on the southeastern Liaodong Peninsula in Northeast China, in order to determine their ages and petrogenesis and further to provide constraint on the tectonic nature of the north segment of Paleoproterozoic Jiao–Liao–Ji Belt. The zircons from the monzogranitic gneisses, magnetite-bearing granitic gneisses, biotite-monzogranitic gneisses, and amphibole-bearing granitic gneisses fall into two groups, namely, magmatic and metamorphic. U–Pb and Lu–Hf isotopic data show that the magmatic zircons have peak ages of ~2,194, 2,485–2,603, and 2,951 Ma, and these age groups yield ε Hf values of +0.86 to +9.29, −3.04 to +3.70, and −2.86 and T C DM model ages of 2.19–2.67, 2.76–3.21, and 3.56 Ga, respectively, whereas the metamorphic zircons have a peak age of 1,910 Ma, ε Hf values of −7.71 to −2.02 and +0.69 to +7.63, with the corresponding T C DM model ages of 2.72 to 3.01 Ga and 2.08 to 2.52 Ga, respectively. Most of these granitic rocks are characterized by depletion in elements such as Nb, Ta, P, Ti, and peraluminous and belong to the high- to medium-K calc-alkaline series, suggesting I-type granites, whereas a few samples have high contents of SiO 2 , alkalis, and TFe 2 O 3 and are metaluminous to weakly peraluminous, which show typical features of A-type granites. We consider these granitic rocks were emplaced at 2,194 Ma and modified by a regional metamorphic event at 1,910 Ma. The parental magma was originated mainly from the partial melting of Neoarchean–Paleoproterozoic juvenile crustal materials. Taking into account the regional geology, we consider these granitic rocks were formed in relation to subduction at an active continental margin. A crustal growth event took place at 2.5–2.2 Ga and a metamorphic event at ~1.9 Ga.
    Print ISSN: 0072-1050
    Electronic ISSN: 1099-1034
    Topics: Geosciences
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2017-09-01
    Description: ABSTRACT Relapses are observed in most HBeAg-negative chronic hepatitis B patients who discontinue nucleos(t)ide analogues (NAs), but the rates of relapse vary widely among studies and whether all patients with relapse need retreatment is unclear. The aim of this study was to assess the impact of different definitions on the rates of post-treatment relapse and therefore on the probability of retreatment in such patients who discontinued effective long-term NAs therapy. In total, 130 non-cirrhotic HBeAg-negative chronic hepatitis B patients before NAs were included. All had on-therapy virological remission for ≥24 months and close follow-up for ≥12 months after stopping NAs or until retreatment, which started on stringent predefined criteria. Relapses rates based on several predetermined definitions of virological and perhaps biochemical criteria were assessed. The median duration of therapy was 60 and of on-therapy virological remission 43 months. During a median off-NAs follow-up of 15 months, no patient experienced liver decompensation or died. Cumulative relapse rates ranged between 2%-49% at 3, 4%-73% at 6, 11%-82% at 12 and 16%-90% at 24 months, whereas cumulative retreatment rates were 15%, 22% and 40% at 6, 12 and 24 months after NAs discontinuation. No patient characteristic was independently associated with the probability of relapse based on at least two definitions or of retreatment. In conclusion, in HBeAg-negative chronic hepatitis B patients who discontinue NAs, the definition of relapse has great impact on the off-NAs relapse rates and potentially on the probability of retreatment. Regardless of definition, off-NAs relapses cannot be easily predicted by the patients' characteristics. A substantial proportion of such patients may not require retreatment if stringent criteria are adopted. This article is protected by copyright. All rights reserved.
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2013-01-16
    Description: Patients dually infected with hepatitis C virus (HCV)/hepatitis B virus (HBV) have a higher risk of developing advanced liver disease or hepatocellular carcinoma compared to monoinfected patients. Our previous study showed a similar rate of sustained virologic response (SVR) after peginterferon alfa-2a and ribavirin combination therapy in these patients compared to HCV monoinfected patients, and a high hepatitis B surface antigen (HBsAg) seroclearance rate. The durability of hepatitis C and B clearance in dually infected patients was investigated by a 5-year follow-up study. Patients with active HCV genotype 1, both HBV coinfected (n=97) and monoinfected (n=110), received a 48-week combination therapy with peginterferon alfa-2a plus ribavirin. Patients with active HCV genotype 2/3, both HBV coinfected (n=64) and monoinfected (n=50) patients received a 24-week combination therapy. A total of 295 (91.9%) patients completed treatment and 24 weeks post-treatment follow-up; 264 (89.5%) agreed to receive additional follow-up for up to 5 years after the end of treatment. After a median follow-up of 4.6 + 1.0 years, 6 of the 232 patients achieving SVR developed HCV RNA reappearance, including 5 HCV genotype 1/HBV coinfected patients and 1 HCV genotype 2/3 monoinfected patient. Subgenomic analysis of the HCV core gene suggested that 5 patients developed delayed recurrence of HCV infection. Overall, the cumulative recurrence rate of HCV infection was 2.3% (0.4%/year; 95% confidence interval [CI]=0.9%∼5.5%). The cumulative HBsAg seroclearance rate was 30.0% (95% CI=21.5%∼42.0%); with 33.1% (95% CI=21.8%∼50.1%) in 48-week combination therapy group and 24.3% (95% CI=13.7%∼42.9%) in 24-week therapy group. Conclusion: Peginterferon alfa-2a and ribavirin therapy provides a good durability of HCV SVR and a high accumulative HBsAg seroclearance rate in patients dually infected with HCV and HBV. (H EPATOLOGY 2013.)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2013-03-09
    Description: The Gulf of Mexico (GOM) is facing large pressures from environmental changes since the beginning of last century. However, the magnitude and long-term trend of total water discharge to the GOM and the underlying processes are not well understood. In this study, the Dynamic Land Ecosystem Model (DLEM) has been improved and applied to investigate spatial and temporal variations of evapotranspiration (ET) and runoff (R) over drainage basins of the GOM during 1901-2008. Modeled ET and discharge were evaluated against up-scaled data sets and gauge observations. Simulated results demonstrated a significant decrease in ET at a rate of 15 mm yr -1 century -1 and an insignificant trend in runoff/precipitation (R/P) and river discharge over the whole region during 1901-2008. However, the trends in estimated water fluxes show substantial spatial and temporal heterogeneities across the study region. Generally, in the west arid area, ET, R, and R/P decreased; while they increased in the eastern part of the study area during the last 108 years. In the resent 30 years this region experienced substantial decrease in R. Factorial simulation experiments indicate that climate change, particularly P, was the dominant factor controlling interannual variations of ET and R; while land use change had the same magnitude of effects on long-term trends in water fluxes as climate change did. To eliminate modeling uncertainties, high-resolution historical meteorological data sets and model parameterizations on anthropogenic effects such as water use and dam constructions should be developed.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2013-03-09
    Description: A one-dimensional Ag I coordination complex, catena -poly[[silver(I)-μ-{2-[2-(pyridin-4-yl)-1 H -benzimidazol-1-ylmethyl]phenol-κ 2 N 2 : N 3 }] perchlorate monohydrate], {[Ag(C 19 H 15 N 3 O)]ClO 4 ·H 2 O} n , was synthesized by the reaction of 2-[2-(pyridin-4-yl)-1 H -benzimidazol-1-ylmethyl]phenol ( L ) with silver perchlorate. In the complex, the L ligands are arranged alternately and link Ag I cations through one benzimidazole N atom and the N atom of the pyridine ring, leading to an extended zigzag chain structure. In addition, the one-dimensional chains are extended into a three-dimensional supramolecular architecture via O—H...O hydrogen-bond interactions and π–π stacking interactions. The complex exhibits photoluminescence in acetonitrile solution, with an emission maximum at 390 nm, and investigation of the thermal stability reveals that the network structure is stable up to 650 K.
    Print ISSN: 0108-2701
    Electronic ISSN: 1600-5759
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...