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  • Wiley  (11)
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  • 1
    Online-Ressource
    Online-Ressource
    Elevated serum uric acid levels are independent risk factors for diabetic foot ulcer in female C hinese patients with type 2 diabetes (血尿酸水平升高是中国女性2型糖尿病患者糖尿病足溃疡的独立危险因素)
    Wiley ; 2014
    In:  Journal of Diabetes Vol. 6, No. 1 ( 2014-01), p. 42-47
    Details
    In: Journal of Diabetes, Wiley, Vol. 6, No. 1 ( 2014-01), p. 42-47
    Kurzfassung: 研究旨在调查中国2型糖尿病患者血尿酸水平升高与发生糖尿病足溃疡的关系。 方法 本研究为回顾性研究，纳入2007年1月到2009年12月期间至糖尿病门诊（南方医院，南方医科大学）就诊的糖尿病患者，共829例（478例男性，351例女性）。收集的信息包括临床病史，人口学指标和实验室数据。P 〈 0.10的潜在混淆变量在多元logistic回归分析中进行校正。 结果 在单变量分析中，伴或不伴糖尿病足溃疡的女性患者的尿酸水平存在显著差异（370 ± 128 vs 313 ± 107 µmol/L，P 〈 0.05），但在男性患者中差异无统计学意义（317 ± 100 vs 348 ± 111 µmol/L，P=0.643）。根据患者的血尿酸水平将其分为五分位区间（从1%‐20%到80%‐100%），糖尿病足溃疡的发生率分别是5.3%，3.9%，7.7%，5.5%和16.7%。将血尿酸水平作为一个连续变量，经多元回归模型校正后女性患者的糖尿病足溃疡的优势比是1.004（95% 可信区间1.001‐1.008；P 〈 0.05）。 结论 对于中国2型糖尿病女性患者，血尿酸水平升高是糖尿病足溃疡的独立危险因素。尿酸是否参与了女性患者糖尿病足溃疡的发病机制仍需要进一步的研究调查。
    Materialart: Online-Ressource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.2014.6.issue-1
    DOI: 10.1111/1753-0407.12079
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2014
    ZDB Id: 2485432-3
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Structured self‐monitoring of blood glucose regimens improve glycemic control in poorly controlled Chinese patients on insulin therapy: Results from COMPASS : 结构化自我血糖监测策略可改善接受胰岛素治疗但血糖控制不佳的中国糖尿病患者的血糖:来自COMPASS研究的结果
    Wiley ; 2017
    In:  Journal of Diabetes Vol. 9, No. 5 ( 2017-05), p. 495-501
    Details
    In: Journal of Diabetes, Wiley, Vol. 9, No. 5 ( 2017-05), p. 495-501
    Kurzfassung: 背景 既往研究显示,在中国接受胰岛素治疗的2型糖尿病患者使用自我血糖监测的情况并不理想。本研究旨在评价结构化自我血糖监测策略对改善血糖控制和提高自我血糖监测频率的有效性。 方法 年龄≥ 18岁、接受胰岛素治疗 〉 3个月、HbA 1c 〉 8%(64 mmol/mol)的2型糖尿病患者入选本研究。本研究为糖尿病患者提供自我血糖监测所需的材料,指导患者按照胰岛素治疗方案进行结构化的自我血糖监测。研究者培训患者根据自我血糖监测结果自行调整胰岛素剂量,并在研究3个月和6个月时进行中心访视。研究终点包括糖化血红蛋白的变化、自我血糖监测频率的变化以及低血糖发生频率的改变。 结果 本研究从中国19个中心入选了820例接受胰岛素治疗的2型糖尿病患者。患者的平均年龄为55.1 ± 9.8岁,体重指数为24.9 ± 3.6 kg/m 2 ,糖化血红蛋白为9.7 ± 1.6%(83 mmol/mol),糖尿病病程为9.8 ± 7.1年,胰岛素治疗时间的中位数为30.3(3.0‐274.1)月。在研究3个月时,99.9%的患者能够每日进行自我血糖监测。在研究3个月和6个月时,患者的糖化血红蛋白较基线分别下降1.81%和1.73%( P 均 〈 0.0001),同时低血糖发生频率降低。此外,研究3个月和6个月时糖化血红蛋白控制达标 〈 7.0%(53 mmol/mol)的患者比例分别为36.2%和39.9%。其中糖尿病病程和胰岛素治疗时间较短的患者糖化血红蛋白改善的幅度最大。 结论 结构化自我血糖监测策略培训患者解读自我血糖监测数据,并根据监测结果进行相应调整。对于接受胰岛素治疗的2型糖尿病患者,该策略在增加自我血糖监测频率的同时可改善患者的血糖控制。
    Materialart: Online-Ressource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.2017.9.issue-5
    DOI: 10.1111/1753-0407.12434
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2485432-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Efficacy and safety of coadministration of sitagliptin with insulin glargine in type 2 diabetes : 西格列汀联合甘精胰岛素治疗2型糖尿病的疗效及安全性
    Wiley ; 2017
    In:  Journal of Diabetes Vol. 9, No. 5 ( 2017-05), p. 502-509
    Details
    In: Journal of Diabetes, Wiley, Vol. 9, No. 5 ( 2017-05), p. 502-509
    Kurzfassung: 背景 评估二肽基肽酶‐4抑制剂西格列汀联合甘精胰岛素在口服降糖药物治疗血糖控制不佳(HbA1c为7%‐9%)的2型糖尿病患者中的疗效和安全性并与预混胰岛素方案进行了比较。 方法 对纳入的65例患者随机分组,试验组(n = 33)采用基础胰岛素联合西格列汀的固定联合治疗方案,对照组(n=32)采用每日2次预混胰岛素方案。主要终点是16周后的HbA1c的改变。次要终点包括空腹血糖,血糖曲线(七个时间点),达到目标HbA1c( 〈 7%或≤ 6.5%)的患者比例,胰岛素剂量,低血糖发生率和体重。 结果 治疗16周后,虽然试验组较对照组有更多患者达到HbA1c 〈 7.0%,但是两组中HbA1c自基线的平均改变无显著性差异。试验组较对照组体重改变明显,试验组体重降低0.45 Kg,对照组体重升高1.52 Kg,差异有统计学意义( P 〈 0.001)。SMBG显示,试验组较对照组的平均血糖及平均血糖波动幅度水平更低,差异显著( P 〈 0.005)。两组报告的症状性低血糖发生率分别为2.85 %和13.3%,差异有统计学意义( P 〈 0.001)。 结论 西格列汀联合甘精胰岛素方案可显著改善HbA1c为7%‐9%的2型糖尿病患者的血糖,不劣于预混胰岛素的效果。因此,西格列汀联合甘精胰岛素方案是口服降糖药物治疗血糖控制不佳患者的一个可行的治疗选择。
    Materialart: Online-Ressource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.2017.9.issue-5
    DOI: 10.1111/1753-0407.12436
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2485432-3
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  • 4
    Online-Ressource
    Online-Ressource
    Prevalence and risk factors of diabetic peripheral neuropathy: A population‐based cross‐sectional study in China
    Wiley ; 2023
    In:  Diabetes/Metabolism Research and Reviews
    Details
    In: Diabetes/Metabolism Research and Reviews, Wiley
    Kurzfassung: To assess the prevalence of diabetic peripheral neuropathy (DPN) and its risk factors in the type 2 diabetes mellitus (T2DM) population. Methods This cross‐sectional study enroled patients with T2DM between July and December 2017 from 24 provinces in China. Diabetic peripheral neuropathy and its severity were assessed by the Toronto clinical scoring system, neuropathy symptoms score (NSS) and neuropathy disability score. The prevalence of DPN and its risk factors were analysed. Results A total of 14,908 patients with T2DM were enroled. The prevalence of DPN was 67.6%. Among 10,084 patients with DPN, 4808 (47.7%), 3325 (33.0%), and 1951 (19.3%) had mild, moderate, and severe DPN, respectively. The prevalence of DPN in females was higher than in males (69.0% vs. 66.6%, P  = 0.002). The prevalence of DPN increased with age and course of diabetes and decreased with body mass index (BMI) and education level (all P for trend 〈 0.05). The comorbidities and complications in patients with DPN were higher than in those without DPN, including hypertension, myocardial infarction, diabetic retinopathy, and diabetic nephropathy (all P   〈  0.001). Age, hypertension, duration of diabetes, diabetic retinopathy, diabetic nephropathy, glycated haemoglobin, high‐density lipoprotein cholesterol, and lower estimated glomerular filtration rate were positively associated with DPN, while BMI, education level, fasting C‐peptide, and uric acid were negatively associated with DPN. Conclusions Among patients with T2DM in China, the prevalence of DPN is high, especially in the elderly, low‐income, and undereducated patients.
    Materialart: Online-Ressource
    ISSN: 1520-7552 , 1520-7560
    URL: Article
    DOI: 10.1002/dmrr.3702
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2001565-3
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  • 5
    Online-Ressource
    Online-Ressource
    MiR‐4756 promotes albumin‐induced renal tubular epithelial cell epithelial‐to‐mesenchymal transition and endoplasmic reticulum stress via targeting Sestrin2
    Wiley ; 2019
    In:  Journal of Cellular Physiology Vol. 234, No. 3 ( 2019-03), p. 2905-2915
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 234, No. 3 ( 2019-03), p. 2905-2915
    Kurzfassung: Accumulating evidence indicates that proteinuria promotes the progression of diabetic kidney disease (DKD) and induces renal epithelial tubular cell epithelial‐to‐mesenchymal transition (EMT) and endoplasmic reticulum (ER) stress, but the mechanism remains unclear. In our previous research, we found that miR‐4756 levels were increased in the urinary extracellular vesicles of type 2 diabetes mellitus patients with macroalbuminuria. In a preliminary study, we found that miR‐4756 may be derived from renal tubular epithelial cells, but its role has not been elucidated. Albumin stimulation significantly increased miR‐4756 levels in HK‐2 cells. In addition, an miR‐4756 mimic accelerated albumin‐stimulated HK‐2 cell EMT and ER stress, and an miR‐4756 inhibitor suppressed these events. We then found that miR‐4756 targeted the 3′‐untranslated region (UTR) of Sestrin2 and directly suppressed Sestrin2 expression. Furthermore, the induction of EMT and ER stress by the overexpression of miR‐4756 was abolished by Sestrin2 overexpression. Moreover, the overexpression of miR‐4756 increased ERK1/2 activation and decreased 5′ monophosphate‐activated protein kinase activation. Thus, our study provides evidence that miR‐4756 accelerates the process of DKD through Sestrin2, suggesting that targeting miR‐4756 may be a novel strategy for DKD treatment.
    Materialart: Online-Ressource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v234.3
    DOI: 10.1002/jcp.27107
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2019
    ZDB Id: 1478143-8
    SSG: 12
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  • 6
    Online-Ressource
    Online-Ressource
    The digestion property evaluation of oil embedded in soybean protein–phospholipid nanocomposite aggregate particle
    Wiley ; 2021
    In:  Journal of Food Process Engineering Vol. 44, No. 12 ( 2021-12)
    Details
    In: Journal of Food Process Engineering, Wiley, Vol. 44, No. 12 ( 2021-12)
    Kurzfassung: This research aimed to explore the digestion properties of oil embedded in the soybean protein–phospholipid (PC) nanocomposite aggregate particles through gastrointestinal digestion model. Soybean protein isolate (SPI), before and after enzymatically hydrolyzed, was combined with PC to form SPI‐PC and enzymatically hydrolyzed SPI‐PC (EHSPI‐PC) nanocomposite aggregate particles. In the process of stomach dynamic digestion, the zeta potential of SPI‐PC changed from −23.50 to 0.40 mV and the Z‐average particle size reached 1,452.00 nm at 70 min while the zeta potential of EHSPI‐PC changed from −45.63 to 6.13 mV and the Z‐average particle size was 594.77 nm. EHSPI‐PC had larger zeta‐potential absolute value and smaller particle size compared with SPI‐PC. It indicated EHSPI‐PC nanocomposite aggregate particles were good gastrointestinal protective carriers. After adding soybean oil, EHSPI‐PC showed denser and smaller droplet morphologies and more surface charge during the digestion process. Compared with SPI‐PC, it also had better emulsification activity and emulsification stability. In conclusion, EHSPI‐PC is more suitable for embedding soybean oil to release in the small intestine. Practical Applications Nano‐aggregate particles are widely used in food, medicine, and chemical industries due to their unique physical and chemical properties and functional properties. However, nano‐aggregate particles have unsatisfactory packaging of emulsifiers and leakage of embedded materials. Enzymatically hydrolyzed soybean protein isolate–phospholipid (EHSPI‐PC) nanocomposite aggregate particles have good emulsification and long‐lasting stability. The results showed that it is feasible for EHSPI‐PC nanocomposite aggregate particles to embed oily substances to ensure that the substances perform their functions in the intestinal tract. Therefore, the delivery system based on the EHSPI‐PC nanocomposite aggregate particles has good development potential in the food and pharmaceutical industries for encapsulation, protection, and release of nonpolar substances.
    Materialart: Online-Ressource
    ISSN: 0145-8876 , 1745-4530
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpe.v44.12
    DOI: 10.1111/jfpe.13914
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2175259-X
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  • 7
    Online-Ressource
    Online-Ressource
    Dapagliflozin reverses the imbalance of T helper 17 and T regulatory cells by inhibiting SGK1 in a mouse model of diabetic kidney disease
    Wiley ; 2021
    In:  FEBS Open Bio Vol. 11, No. 5 ( 2021-05), p. 1395-1405
    Details
    In: FEBS Open Bio, Wiley, Vol. 11, No. 5 ( 2021-05), p. 1395-1405
    Kurzfassung: An imbalance between T helper 17 (Th17) and T regulatory (Treg) cell subsets contributes to the pathogenesis of diabetic kidney disease (DKD). However, the underlying regulatory mechanisms that cause this imbalance are unknown. Serum/glucocorticoid‐regulated kinase 1 (SGK1) has been suggested to affect Th17 polarization in a salt‐dependent manner, and sodium/glucose cotransporter 2 inhibitors (SGLT2i) have been demonstrated to regulate sodium‐mediated transportation in the renal tubules. This study aimed to evaluate the potential benefits of dapagliflozin (Dap) on DKD, as well as its influence on shifting renal T‐cell polarization and related cytokine secretion. We treated male db/db mice with Dap or voglibose (Vog) and measured blood and kidney levels of Th17 and Treg cells using flow cytometry. We found that Th17 cells were significantly increased, while Treg cells were significantly decreased in diabetic mice. Moreover, Dap suppressed the polarization of Th17/Treg cells by inhibiting SGK1 in diabetic kidneys, and this was accompanied by attenuation of albuminuria and tubulointerstitial fibrosis independent of glycemic control. Taken together, these results demonstrate that the imbalance of Th17/Treg cells plays an important role in the progression of DKD. Moreover, Dap protects against DKD by inhibiting SGK1 and reversing the T‐cell imbalance.
    Materialart: Online-Ressource
    ISSN: 2211-5463 , 2211-5463
    URL: Issue
    URL: Article
    DOI: 10.1002/feb4.v11.5
    DOI: 10.1002/2211-5463.13147
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2651702-4
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  • 8
    Online-Ressource
    Online-Ressource
    Microbial community responses reduce soil carbon loss in Tibetan alpine grasslands under short‐term warming
    Wiley ; 2019
    In:  Global Change Biology Vol. 25, No. 10 ( 2019-10), p. 3438-3449
    Details
    In: Global Change Biology, Wiley, Vol. 25, No. 10 ( 2019-10), p. 3438-3449
    Kurzfassung: Changes in labile carbon (LC) pools and microbial communities are the primary factors controlling soil heterotrophic respiration ( R h ) in warming experiments. Warming is expected to initially increase R h but studies show this increase may not be continuous or sustained. Specifically, LC and soil microbiome have been shown to contribute to the effect of extended warming on R h . However, their relative contribution is unclear and this gap in knowledge causes considerable uncertainty in the prediction of carbon cycle feedbacks to climate change. In this study, we used a two‐step incubation approach to reveal the relative contribution of LC limitation and soil microbial community responses in attenuating the effect that extended warming has on R h . Soil samples from three Tibetan ecosystems—an alpine meadow (AM), alpine steppe (AS), and desert steppe (DS)—were exposed to a temperature gradient of 5–25°C. After an initial incubation period, soils were processed in one of two methods: (a) soils were sterilized then inoculated with parent soil microbes to assess the LC limitation effects, while controlling for microbial community responses; or (b) soil microbes from the incubations were used to inoculate sterilized parent soils to assess the microbial community effects, while controlling for LC limitation. We found both LC limitation and microbial community responses led to significant declines in R h by 37% and 30%, respectively, but their relative contributions were ecosystem specific. LC limitation alone caused a greater R h decrease for DS soils than AMs or ASs. Our study demonstrates that soil carbon loss due to R h in Tibetan alpine soils—especially in copiotrophic soils—will be weakened by microbial community responses under short‐term warming.
    Materialart: Online-Ressource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    URL: Article
    DOI: 10.1111/gcb.v25.10
    DOI: 10.1111/gcb.14734
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2019
    ZDB Id: 2020313-5
    SSG: 12
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  • 9
    Online-Ressource
    Online-Ressource
    Development and validation of a prognostic model incorporating tumor thrombus grading for nonmetastatic clear cell renal cell carcinoma with tumor thrombus: A multicohort study
    Wiley ; 2023
    In:  MedComm Vol. 4, No. 4 ( 2023-08)
    Details
    In: MedComm, Wiley, Vol. 4, No. 4 ( 2023-08)
    Kurzfassung: There is significant variability with respect to the prognosis of nonmetastatic clear cell renal cell carcinoma (ccRCC) patients with venous tumor thrombus (VTT). By applying multiregion whole‐exome sequencing on normal‐tumor‐thrombus‐metastasis quadruples from 33 ccRCC patients, we showed that metastases were mainly seeded by VTT (81.8%) rather than primary tumors (PTs). A total of 706 nonmetastatic ccRCC patients with VTT from three independent cohorts were included in this study. C‐index analysis revealed that pathological grading of VTT outperformed other indicators in risk assessment (OS: 0.663 versus 0.501–0.610, 0.667 versus 0.544–0.651, and 0.719 versus 0.511–0.700 for Training, China‐Validation, and Poland‐Validation cohorts, respectively). We constructed a risk predicting model, TT‐GPS score, based on four independent variables: V TT height, VTT g rading, p erinephric fat invasion, and s arcomatoid differentiation in PT. The TT‐GPS score displayed better discriminatory ability (OS, c‐index: 0.706–0.840, AUC: 0.788–0.874; DFS, c‐index: 0.691–0.717, AUC: 0.771–0.789) than previously reported models in risk assessment. In conclusion, we identified for the first‐time pathological grading of VTT as an unheeded prognostic factor. By incorporating VTT grading, the TT‐GPS score is a promising prognostic tool in predicting the survival of nonmetastatic ccRCC patients with VTT.
    Materialart: Online-Ressource
    ISSN: 2688-2663 , 2688-2663
    URL: Issue
    URL: Article
    DOI: 10.1002/mco2.v4.4
    DOI: 10.1002/mco2.300
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 3021470-1
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  • 10
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    Volcanic rocks distribution and basement structure in western–central Junggar Basin revealed by gravitational and magnetic data
    Wiley ; 2018
    In:  Geological Journal Vol. 53, No. 3 ( 2018-05), p. 960-976
    Details
    In: Geological Journal, Wiley, Vol. 53, No. 3 ( 2018-05), p. 960-976
    Kurzfassung: The Junggar Basin is a large superimposed basin with multistage evolution. The Carboniferous volcanic rock in the middle‐lower part of the basin has been an important target of oil and gas exploration. Therefore, it is crucial to establish a set of efficient methods and techniques to find out the distribution of the Carboniferous volcanic rock and the tectonic factors related to the reservoir forming of the volcanic rock. Our research reveals that the density and magnetism of the Carboniferous volcanic rock are obviously higher than those of the Mesozoic and Cenozoic sedimentary rocks. With a series of frequency domain filters and boundary enhancement techniques, we determine the residual gravitational and magnetic anomalies caused by the Carboniferous volcanic rock. Combined with borehole and seismic data from the studied areas, the horizontal and vertical distributions of the Carboniferous volcanic rock are defined, and the lithologies of different types of volcanic rocks are predicted. Furthermore, the gravitational and magnetic anomalies are used to estimate the basement faults and topography. The regional deep faults and their secondary faults of the basement are outlined, and the model of basement relief is constructed. Finally, the effects of the fracture structure and the basement topography in the process of volcanic activity and hydrocarbon accumulation are fully discussed. These results provide fundamental information for optimal selection of the favorable area of volcanic reservoir.
    Materialart: Online-Ressource
    ISSN: 0072-1050 , 1099-1034
    URL: Issue
    URL: Article
    DOI: 10.1002/gj.v53.3
    DOI: 10.1002/gj.2937
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 1479201-1
    SSG: 13
    Standort Signatur Einschränkungen Verfügbarkeit
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