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  • 1
    Online Resource
    Online Resource
    Knowledge of HbA1c and LDL‐C treatment goals, subjective level of disease‐related information and information needs in patients with atherosclerotic cardiovascular disease
    Wiley ; 2023
    In:  Clinical Cardiology Vol. 46, No. 2 ( 2023-02), p. 223-231
    Details
    In: Clinical Cardiology, Wiley, Vol. 46, No. 2 ( 2023-02), p. 223-231
    Abstract: Risk factor control of diabetes mellitus (DM) and especially dyslipidemia remains unsatisfactory in patients with atherosclerotic cardiovascular disease (ASCVD). We aimed to analyze the knowledge of low‐density lipoprotein cholesterol (LDL‐C) and glycated hemoglobin (HbA1c) treatment goals, subjective level of information, and information needs in very high‐risk patients with ASCVD. Methods ASCVD patients ( n  = 210; 75 ± 9 years; 71.4% male; 89.5% coronary disease) with DM (96.7% type 2) completed a questionnaire assessing knowledge of HbA1c and LDL‐C treatment goals and subjective level of information and information needs on disease‐related topics of DM and ASCVD. Serum LDL‐C and HbA1c were measured. Results HbA1c goal ( 〈 7.0% in 60.6%) was attained more frequently than LDL‐C goal ( 〈 70 mg/dl in 39.9%; p   〈  .01). Significantly more participants named the correct goal for HbA1c compared to LDL‐C (52.9% vs. 2.4%; p   〈  .01). Subjective levels of information were higher and information needs were lower for DM than for ASCVD ( p   〈  .01 for all topics). No associations of knowledge of treatment goals and level of information with the attainment of treatment goals for HbA1c and LDL‐C were found. However, in multivariate regression, higher levels of education were associated with knowledge of treatment goals (HbA1c: odds ratio [OR] 1.32, 95% confidence interval [CI] 1.01–1.72, p  = .04; LDL‐C: OR 2.32, 95% CI 1.07–5.03; p  = .03). Conclusion In very high‐risk patients with ASCVD, a deficit of knowledge of treatment goals to control dyslipidemia exists when compared to DM, patients felt significantly better informed for topics of DM than for ASCVD and display higher information needs for topics of ASCVD.
    Type of Medium: Online Resource
    ISSN: 0160-9289 , 1932-8737
    URL: Issue
    URL: Article
    DOI: 10.1002/clc.v46.2
    DOI: 10.1002/clc.23948
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2048223-1
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  • 2
    Online Resource
    Online Resource
    The effect of tranexamic acid on perioperative blood loss in transurethral resection of the prostate: A double‐blind, randomized controlled trial
    Wiley ; 2023
    In:  The Prostate
    Details
    In: The Prostate, Wiley
    Abstract: Bleeding and bleeding‐related complications remain common after bipolar transurethral resection of the prostate (TURP) for benign prostatic hyperplasia. This may possibly lead to prolonged postoperative irrigation, catheterization, and hospital stay. The objective of this trial was to evaluate the effect of high‐dose tranexamic acid (TXA) on perioperative blood loss in patients treated with bipolar TURP for prostate sizes between 30 and 80 g. Methods We conducted a single‐center, prospective, double‐blind, randomized controlled trial. Eighty patients were screened for inclusion between March 2020 and January 2023. After exclusion, 65 patients were randomized in two comparable groups. The TXA group (31 patients) received a TXA intravenous loading dose of 10 mg/kg over 30 min before induction, followed by a maintenance dose of 5 mg/kg/h over 12 h. The placebo group (34 patients) received an equal dose of saline infusion. We measured age, weight, preoperative prostate size, anticoagulant use, 5‐alpha reductase inhibitor use, preoperative urinary tract infection, American Society of Anesthesiologists score, difference in pre‐ and 24 h postoperative hemoglobin and hematocrit levels, operative time, resected adenoma weight, duration of postoperative irrigation, total amount of postoperative irrigation fluid, indwelling catheter time, duration of hospital stay, blood transfusion rate, and 4‐week complication rate. Results Baseline characteristics in both groups were comparable. Postoperative hemoglobin decrease in TXA versus placebo group was 1 versus 1.6 mg/dL, respectively ( p  = 0.04). In addition, the amount of postoperative irrigation fluid (10.7 vs. 18.5 L), irrigation time (24.3 vs. 37.9 h), catheterization time (40.8 vs. 53.7 h), and hospital stay (46.9 vs. 59.2 h) were statistically significant in favor of TXA use. No blood transfusions were carried out. Four‐week complication rate was comparable between the two groups. Conclusions Perioperative high‐dose TXA seems beneficial in reducing hemoglobin loss, postoperative irrigation, catheterization time, and hospital stay in bipolar TURP for prostate sizes between 30 and 80 g, without increased risk of TXA‐related thromboembolic events.
    Type of Medium: Online Resource
    ISSN: 0270-4137 , 1097-0045
    URL: Article
    DOI: 10.1002/pros.24616
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1494709-2
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