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  • 1
    Online Resource
    Online Resource
    Clinical definition of secondary resistance to immunotherapy in non‐small cell lung cancer
    Wiley ; 2023
    In:  Thoracic Cancer Vol. 14, No. 34 ( 2023-12), p. 3421-3429
    Details
    In: Thoracic Cancer, Wiley, Vol. 14, No. 34 ( 2023-12), p. 3421-3429
    Abstract: Immune checkpoint inhibitors (PD‐1/PD‐L1 and CTLA‐4 blockade) have revolutionized the treatment landscape in non‐small cell lung cancer (NSCLC). Secondary resistance to immunotherapy (IO), which poses a substantial challenge in clinical settings, occurs in several initial responders. Currently, new treatment approaches have been extensively evaluated in investigational studies for these patients to tackle this difficult problem; however, the lack of consistency in clinical definition, uniform criteria for enrollment in clinical trials, and interpretation of results remain significant hurdles to progress. Thus, our expert panel comprehensively synthesized data from current studies to propose a practical clinical definition of secondary resistance to immunotherapy in NSCLC in metastatic and neoadjuvant settings. In addition to patients who received IO alone (including IO‐IO combinations), we also generated a definition for patients treated with chemotherapy plus IO. This consensus aimed to provide guidance for clinical trial design and facilitate future discussions with investigators. It should be noted that additional updates in this consensus are required when new data is available.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v14.34
    DOI: 10.1111/1759-7714.15157
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2559245-2
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  • 2
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    Online Resource
    MiR‐106b inhibition suppresses inflammatory bone destruction of wear debris‐induced periprosthetic osteolysis in rats
    Wiley ; 2020
    In:  Journal of Cellular and Molecular Medicine Vol. 24, No. 13 ( 2020-07), p. 7490-7503
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 24, No. 13 ( 2020-07), p. 7490-7503
    Abstract: Aseptic loosening caused by periprosthetic osteolysis (PPO) is the main reason for the primary artificial joint replacement. Inhibition of inflammatory osteolysis has become the main target of drug therapy for prosthesis loosening. MiR‐106b is a newly discovered miRNA that plays an important role in tumour biology, inflammation and the regulation of bone mass. In this study, we analysed the in vivo effect of miR‐106b on wear debris‐induced PPO. A rat implant loosening model was established. The rats were then administrated a lentivirus‐mediated miR‐106b inhibitor, miR‐106b mimics or an equivalent volume of PBS by tail vein injection. The expression levels of miR‐106b were analysed by real‐time PCR. Morphological changes in the distal femurs were assessed via micro‐CT and histopathological analysis, and cytokine expression levels were examined via immunohistochemical staining and ELISA. The results showed that treatment with the miR‐106b inhibitor markedly suppressed the expression of miR‐106b in distal femur and alleviated titanium particle‐induced osteolysis and bone loss. Moreover, the miR‐106b inhibitor decreased TRAP‐positive cell numbers and suppressed osteoclast formation, in addition to promoting the activity of osteoblasts and increasing bone formation. MiR‐106b inhibition also significantly regulated macrophage polarization and decreased the inflammatory response as compared to the control group. Furthermore, miR‐106b inhibition blocked the activation of the PTEN/PI3K/AKT and NF‐κB signalling pathways. Our findings indicated that miR‐106b inhibition suppresses wear particles‐induced osteolysis and bone destruction and thus may serve as a potential therapy for PPO and aseptic loosening.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v24.13
    DOI: 10.1111/jcmm.15376
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2076114-4
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  • 3
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    Online Resource
    Molecular dynamics simulation of the surface wettability of typical minerals in shale
    Wiley ; 2023
    In:  Geological Journal Vol. 58, No. 5 ( 2023-05), p. 1990-2001
    Details
    In: Geological Journal, Wiley, Vol. 58, No. 5 ( 2023-05), p. 1990-2001
    Abstract: Nanoscale pores are an important storage space in shale petroleum reservoirs. Mineral surface wettability significantly affects the adsorption ability of a fluid, and it is of great significance for the efficient development of shale petroleum. Within a nanoscale pore, however, we cannot measure the contact angle through a conventional measuring method, so we used a molecular dynamics (MD) simulation method. A nanoscale ‘oil–water–rock’ wettability model was used to study the wettability of reservoir minerals with micropores. In this study, by means of MD simulation, the wettability models of different minerals (calcite, quartz and illite) and different liquid hydrocarbons ( n ‐hexane, toluene and acetic acid) were established, and then the temperature and pressure were changed to study the influence of mineral type, liquid hydrocarbon type, temperature and pressure on wettability. The results show that calcite has the strongest wettability of water in n ‐hexane, followed by illite and quartz, and toluene has the strongest wettability of water on the surface of calcite minerals, followed by n ‐hexane and acetic acid. In the temperature range of 313–378 K, the higher the temperature, the stronger the water wettability. In the pressure range of 5–20 MPa, the higher the pressure, the water wettability is stronger. By comparing the MD simulation results with the previous experimental results, similar wetting characteristics were obtained, which verified the reliability of the simulation results. This MD simulation method provides a new idea for the study of shale mineral wettability, which is of great significance for shale petroleum exploration.
    Type of Medium: Online Resource
    ISSN: 0072-1050 , 1099-1034
    URL: Issue
    URL: Article
    DOI: 10.1002/gj.v58.5
    DOI: 10.1002/gj.4703
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1479201-1
    SSG: 13
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  • 4
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    Differences between novel hybrid mode flaps and traditional perforator flaps at the level of metabolites using LC–MS
    Wiley ; 2022
    In:  Biomedical Chromatography Vol. 36, No. 11 ( 2022-11)
    Details
    In: Biomedical Chromatography, Wiley, Vol. 36, No. 11 ( 2022-11)
    Abstract: The multi‐territory perforator flaps are widely used in plastic surgery. However, partial necrosis flap in the potential territory remains a challenge to plastic surgeons. We raised a novel “hybrid nourished mode” (HNM) flap based on the multi‐territory deep inferior epigastric perforator (DIEP) flap to improve flap survival. Thirty‐two rabbits were randomly divided into DIEP and HNM groups. Untargeted metabolic mechanisms between the DIEP and HNM groups were performed using LC–MS under the filter criteria of fold change 〉 20.0 times or 〈 0.05, and variable importance in projection (VIP) value was set at ≥1, P   〈  0.05. Between the two groups, flap survival, perfusion, microvasculature, histopathology, and immunohistochemistry of CD31 were assessed on post‐operative day 7. We screened 16 different metabolites that mainly participated in biosynthesis of secondary metabolites, aminoacyl transfer RNA biosynthesis, phenylalanine metabolism, arginine and proline metabolism, among others. The results of the HNM flaps were higher than those of the DIEP flaps ( P   〈  0.05) in the aspects of flap survival, flap perfusion, and microvasculature. Compared with the DIEP flaps, HNM has a stronger advantage in tissue metabolism. This study provided us with a better understanding and strong evidence in terms of metabolites on how HNM achieves the survival of large multi‐territory perforator flaps.
    Type of Medium: Online Resource
    ISSN: 0269-3879 , 1099-0801
    URL: Issue
    URL: Article
    DOI: 10.1002/bmc.v36.11
    DOI: 10.1002/bmc.5466
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1479945-5
    SSG: 12
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  • 5
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    Cell‐Free Bilayered Porous Scaffolds for Osteochondral Regeneration Fabricated by Continuous 3D‐Printing Using Nascent Physical Hydrogel as Ink
    Wiley ; 2021
    In:  Advanced Healthcare Materials Vol. 10, No. 3 ( 2021-02)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 10, No. 3 ( 2021-02)
    Abstract: Cartilage is difficult to self‐repair and it is more challenging to repair an osteochondral defects concerning both cartilage and subchondral bone. Herein, it is hypothesized that a bilayered porous scaffold composed of a biomimetic gelatin hydrogel may, despite no external seeding cells, induce osteochondral regeneration in vivo after being implanted into mammal joints. This idea is confirmed based on the successful continuous 3D‐printing of the bilayered scaffolds combined with the sol‐gel transition of the aqueous solution of a gelatin derivative (physical gelation) and photocrosslinking of the gelatin methacryloyl (gelMA) macromonomers (chemical gelation). At the direct printing step, a nascent physical hydrogel is extruded, taking advantage of non‐Newtonian and thermoresponsive rheological properties of this 3D‐printing ink. In particular, a series of crosslinked gelMA (GelMA) and GelMA‐hydroxyapatite bilayered hydrogel scaffolds are fabricated to evaluate the influence of the spacing of 3D‐printed filaments on osteochondral regeneration in a rabbit model. The moderately spaced scaffolds output excellent regeneration of cartilage with cartilaginous lacunae and formation of subchondral bone. Thus, tricky rheological behaviors of soft matter can be employed to improve 3D‐printing, and the bilayered hybrid scaffold resulting from the continuous 3D‐printing is promising as a biomaterial to regenerate articular cartilage.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v10.3
    DOI: 10.1002/adhm.202001404
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2645585-7
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  • 6
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    Hypersensitivity in the lungs is responsible for acute respiratory failure in COVID‐19 patients: Case series of patients who received high‐dose/short‐term methylprednisolone
    Wiley ; 2021
    In:  Clinical and Translational Allergy Vol. 11, No. 7 ( 2021-09)
    Details
    In: Clinical and Translational Allergy, Wiley, Vol. 11, No. 7 ( 2021-09)
    Abstract: COVID‐19 is a highly contagious respiratory disease caused by the SARS‐CoV‐2 virus. Patients with severe disease have a high fatality rate and face a huge medical burden due to the need for invasive mechanical ventilation. Hypoxic respiratory failure is the major cause of death in these patients. There are currently no specific anti‐SARS‐CoV‐2 drugs, and the effect of corticosteroids is still controversial. Methods The clinical data of 102 COVID‐19 patients, including 27 patients with severe disease, were analyzed. The serum levels of total IgE and anti‐SARS‐CoV‐2 specific IgE were compared in healthy controls and COVID‐19 patients, changes in the level of anti‐SARS‐CoV‐2 specific IgE and clinical response to methylprednisolone (MP) treatment were analyzed, and the effect of high‐dose/short‐term MP therapy for patients with critical illness and respiratory failure was determined. Results COVID‐19 patients had elevated serum levels of anti‐SARS‐CoV‐2 specific IgE, and patients with severe disease, especially critical illness, had even higher levels. Application of short‐term/high‐dose MP significantly reduced the level of these IgE antibodies and also blocked the progression of hypoxic respiratory failure. Hypoxic respiratory failure in patients with COVID‐19 is related to pulmonary hypersensitivity. Conclusions Hypersensitivity in the lungs is responsible for acute respiratory failure in COVID‐19 patients. Application of high‐dose/short‐term MP appears to be an effective life‐saving method for COVID‐19 patients who have hypoxic respiratory failure.
    Type of Medium: Online Resource
    ISSN: 2045-7022 , 2045-7022
    URL: Issue
    URL: Article
    DOI: 10.1002/clt2.v11.7
    DOI: 10.1002/clt2.12056
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2630865-4
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  • 7
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    Highly Selective Aerobic Oxidation of Alcohol Catalyzed by a Gold(I) Complex with an Anionic Ligand.
    Wiley ; 2006
    In:  ChemInform Vol. 37, No. 21 ( 2006-05-23)
    Details
    In: ChemInform, Wiley, Vol. 37, No. 21 ( 2006-05-23)
    Type of Medium: Online Resource
    ISSN: 0931-7597 , 1522-2667
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/chin.v37:21
    DOI: 10.1002/(ISSN)1522-2667
    DOI: 10.1002/chin.200621041
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2110203-X
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  • 8
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    Oxidation Behavior of Hot Pressed Z r B 2 ‐ Z r C ‐ S i C Ceramic Composites
    Wiley ; 2014
    In:  International Journal of Applied Ceramic Technology Vol. 11, No. 1 ( 2014-01), p. 178-185
    Details
    In: International Journal of Applied Ceramic Technology, Wiley, Vol. 11, No. 1 ( 2014-01), p. 178-185
    Abstract: Dense Z r B 2 ‐ S i C ceramics containing 40 vol% Z r C particles are fabricated via hot pressing method. Then the sintered ceramics are oxidized in air up to 1500°C, and the oxidation kinetics of the ceramic composites is deduced in combination with the reacted fraction curves. As indicated by the experimental results, the oxidation kinetics changes from reaction‐controlled process to diffusion‐controlled one with increasing of oxidation temperature. In addition, the oxidation kinetics parameters are obtained, which indicates that the oxidation resistance decays at elevated temperatures. Furthermore, the evolution of surface morphology and oxide scale during oxidation process is clarified.
    Type of Medium: Online Resource
    ISSN: 1546-542X , 1744-7402
    URL: Issue
    URL: Article
    DOI: 10.1111/ijac.2013.11.issue-1
    DOI: 10.1111/ijac.12000
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2167226-X
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  • 9
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    Analysis of positron emission tomography hypometabolic patterns and neuropsychiatric symptoms in patients with dementia syndromes
    Wiley ; 2023
    In:  CNS Neuroscience & Therapeutics Vol. 29, No. 8 ( 2023-08), p. 2193-2205
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 29, No. 8 ( 2023-08), p. 2193-2205
    Abstract: To estimate the proportions of specific hypometabolic patterns and their association with neuropsychiatric symptoms (NPS) in patients with cognitive impairment (CI). Methods This multicenter study with 1037 consecutive patients was conducted from December 2012 to December 2019. 18 F‐FDG PET and clinical/demographic information, NPS assessments were recorded and analyzed to explore the associations between hypometabolic patterns and clinical features by correlation analysis and multivariable logistic regression models. Results Patients with clinical Alzheimer's disease (AD, 81.6%, 605/741) and dementia with Lewy bodies (67.9%, 19/28) mostly had AD‐pattern hypometabolism, and 76/137 (55.5%) of patients with frontotemporal lobar degeneration showed frontal and anterior temporal pattern (FT‐P) hypometabolism. Besides corticobasal degeneration, patients with behavioral variant frontotemporal dementia (36/58), semantic dementia (7/10), progressive non‐fluent aphasia (6/9), frontotemporal lobar degeneration and amyotrophic lateral sclerosis (3/5), and progressive supranuclear palsy (21/37) also mostly showed FT‐P hypometabolism. The proportion of FT‐P hypometabolism was associated with the presence of hallucinations ( R  = 0.171, p  = 0.04), anxiety ( R  = 0.182, p  = 0.03), and appetite and eating abnormalities ( R  = 0.200, p  = 0.01) in AD. Conclusion Specific hypometabolic patterns in FDG‐PET are associated with NPS and beneficial for the early identification and management of NPS in patients with CI.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.14169
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2423467-9
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  • 10
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    A Humidity‐Insensitive Waterborne Polyurethane Pressure‐Sensitive Adhesive Modified by Castor Oil and Siloxane
    Wiley ; 2023
    In:  ChemistrySelect Vol. 8, No. 17 ( 2023-05-05)
    Details
    In: ChemistrySelect, Wiley, Vol. 8, No. 17 ( 2023-05-05)
    Abstract: Although waterborne polyurethane pressure‐sensitive (PSA) has achieved great progress, achieving robust effective adhesion on the wet substrate surface is still challenging. Herein, we developed a humidity‐insensitive waterborne polyurethane pressure‐sensitive adhesive through the modification of bio‐based castor oil and 3‐aminopropyl triethoxysilane (APTES) as the end‐capper. Improved bonding property on wet substrate via drainage of hydrophobic groups led to better humidity‐insensitive adhesiveness. The results exhibited exceptional bonding performance (∼3.3N/25 mm) on the moist surface of the steel in the environment with a humidity of 100 % RH (Relative Humidity). Especially, the 180° peel forces of siloxane‐terminated castor oil‐based waterborne polyurethane (SCWPU) respectively enhanced by 13.33 % and 73.68 % compared with the blank sample when the air humidity increased from 50 % RH to 100 % RH. Silicone had the advantages of low surface energy, good heat resistance and good oxidation resistance. The heat resistance could be improved by introducing silicone into waterborne polyurethane. Tested by the TGA, the SCWPU3 PSA demonstrated great thermal stability (T HRI =144.32 °C). Besides, the PSA also exhibited low water absorption (20.6 %), and eligible viscoelasticity properties. These findings provided an impetus for the development of humidity‐insensitive PSA.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v8.17
    DOI: 10.1002/slct.202300699
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2844262-3
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