In:
European Journal of Organic Chemistry, Wiley, Vol. 2017, No. 16 ( 2017-04-26), p. 2223-2229
Kurzfassung:
The inhibition of PARP‐1 (poly[ADP‐ribose]polymerase 1), a key enzyme for DNA quality control, has been achieved with synthetic molecular tweezers through a noncompetitive mechanism with an IC 50 value of 3 µ m . Displacement as well as electrophoretic mobility shift assays and molecular dynamics experiments point to a simultaneous inclusion of lysine side‐chains in the cavity of the tweezers and the coordination of one phosphate arm to the central Zn 2+ ion of the zinc finger; thereby, lesioned DNA is displaced.
Materialart:
Online-Ressource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2017.16
DOI:
10.1002/ejoc.201601596
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2017
ZDB Id:
1475010-7
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