In:
Catheterization and Cardiovascular Interventions, Wiley, Vol. 87, No. 3 ( 2016-02-15), p. 363-373
Abstract:
Outcomes with bivalirudin compare favorably with heparin ± GPIIb/IIIa receptor inhibition (heparin ± GPI) during percutaneous coronary intervention (PCI). Patients with congestive heart failure (CHF) have increased risk for complications. The objective was to investigate clinical and economic outcomes for bivalirudin ± GPI vs. heparin ± GPI among PCI patients with CHF. Methods Using the Premier Hospital Database, PCI patients with CHF were stratified by anticoagulant: bivalirudin, bivalirudin ± GPI, heparin and heparin ± GPI. The probability of receiving bivalirudin ± GPI was estimated using individual and hospital variables. Using propensity scores, each bivalirudin ± GPI patient was matched to a heparin ± GPI patient. The primary outcome was in‐hospital death. Bleeding rates, transfusion, length of stay and in‐hospital cost were ascertained. Results Overall, 116,313 patients at 315 hospitals received bivalirudin ( n = 45,559) bivalirudin + GPI ( n = 8,115), heparin ( n = 27,972) or heparin + GPI ( n = 34,667). Patients had STEMI (21.2%), NSTEMI (29.1%), unstable angina (16.6%), stable angina (5.7%) or other ischemic heart disease (24.2%). Of these, 79.1% of bivalirudin patients matched, resulting in 84,948 analyzed patients. Compared with heparin ± GPI patients, bivalirudin ± GPI patients had fewer deaths (3.3% vs. 3.9%; p 〈 0.0001), less clinically apparent bleeding (10.2% vs. 11.4%; p 〈 0.0001), clinically apparent bleeding with transfusion (2.7% vs. 3.2%, p 〈 0.0001), and transfusion (8.5% vs. 9.8%, p 〈 0.0001). Patients receiving bivalirudin had shorter length of stay (6.3 vs. 6.8 days; p 〈 0.0001) and lower in‐hospital cost (mean $26,706 vs. $27,166 [median $19,414 vs. $19,798]; p 〈 0.0001). In conclusion, this is the largest retrospective analysis of PCI patients with CHF and demonstrates bivalirudin ± GPI compared with heparin ± GPI is associated with lower inpatient rates of death, bleeding, and cost. © 2015 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1522-1946
,
1522-726X
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2001555-0
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