In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1099, No. 1 ( 2007-03), p. 481-485
Abstract:
Abstract: Chemical hypoxia produces depletion of ATP, intracellular Ca 2+ overload, and cell death. The role of Na + /Ca 2+ exchanger (NCX), the major plasma membrane Ca 2+ extruding system, has been explored in chemical hypoxia using BHK cells stably transfected with the three mammalian NCX isoforms: NCX1, NCX2, and NCX3. Here we report that the three isoforms show similar activity evaluated as [Ca 2+ ] i increase evoked by Na + ‐free medium exposure in Fura‐2‐loaded single cells and NCX3 transfected cells are less vulnerable to chemical hypoxia compared to NCX1‐ and NCX2‐transfected cells, suggesting that NCX3 could play a more relevant protective role during chemical hypoxia.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1387.052
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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