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  • 1
    Online Resource
    Online Resource
    Inflammation of the periodontium associates with risk of future cardiovascular events
    Wiley ; 2021
    In:  Journal of Periodontology Vol. 92, No. 3 ( 2021-03), p. 348-358
    Details
    In: Journal of Periodontology, Wiley, Vol. 92, No. 3 ( 2021-03), p. 348-358
    Abstract: While growing evidence suggests a link between periodontal disease (PD) and cardiovascular disease (CVD), the independence of this association and the pathway remain unclear. Herein, we tested the hypotheses that: (1) inflammation of the periodontium (PD inflammation ) predicts future CVD independently of disease risk factors shared between CVD and PD, and (2) the mechanism linking the two diseases involves heightened arterial inflammation. Methods 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F‐FDG‐PET/CT) imaging was performed in 304 individuals (median age 54 years; 42.4% male) largely for cancer screening; individuals without active cancer were included. PD inflammation and arterial inflammation were quantified using validated 18 F‐FDG‐PET/CT methods. Additionally, we evaluated the relationship between PD inflammation and subsequent major adverse cardiovascular events (MACE) using Cox models and log‐rank tests. Results Thirteen individuals developed MACE during follow‐up (median 4.1 years). PD inflammation associated with arterial inflammation, remaining significant after adjusting for PD and CVD risk factors (standardized β [95% CI]: 0.30 [0.20‐0.40] , P   〈  0.001). PD inflammation predicted subsequent MACE (standardized HR [95% CI]: 2.25 [1.47 to 3.44] , P   〈 0.001, remaining significant in multivariable models), while periodontal bone loss did not. Furthermore, mediation analysis suggested that arterial inflammation accounts for 80% of the relationship between PD inflammation and MACE (standardized log odds ratio [95% CI]: 0.438 [0.019‐0.880] , P  = 0.022). Conclusion PD inflammation is independently associated with MACE via a mechanism that may involve increased arterial inflammation. These findings provide important support for an independent relationship between PD inflammation and CVD.
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Issue
    URL: Article
    DOI: 10.1002/jper.v92.3
    DOI: 10.1002/JPER.19-0441
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2040047-0
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  • 2
    Online Resource
    Online Resource
    Effects of Cecropin Transgenesis and Interspecific Hybridization on the Resistance to Ichthyophthirius multifiliis in Channel Catfish and Female Channel Catfish × Male Blue Catfish Hybrids
    Wiley ; 2019
    In:  North American Journal of Aquaculture Vol. 81, No. 3 ( 2019-07), p. 242-252
    Details
    In: North American Journal of Aquaculture, Wiley, Vol. 81, No. 3 ( 2019-07), p. 242-252
    Abstract: The resistance of Channel Catfish Ictalurus punctatus , hybrid catfish (female Channel Catfish × male Blue Catfish I. furcatus [ CB hybrids]), and Channel Catfish and hybrid catfish expressing the introduced cecropin B gene to Ichthyophthirius multifiliis infestation was investigated in two experiments. In experiment I, four fingerling groups were challenged, including cecropin‐transgenic Channel Catfish, cecropin‐transgenic CB hybrids, non‐transgenic Channel Catfish, and non‐transgenic CB hybrids. Non‐transgenic Channel Catfish survived for a shorter time than the other three groups. Survival rate was significantly different between non‐transgenic Channel Catfish and the other groups, which had similar survival rates. In experiment II , non‐transgenic CB hybrids had a less severe infestation than non‐transgenic Channel Catfish. Mortality rates were 62.4% and 40.2% for non‐transgenic Channel Catfish and CB hybrids, respectively. The mean survival time for non‐transgenic hybrids was significantly longer ( 〉 5 d) than that of non‐transgenic Channel Catfish. The results suggest that genetic enhancement of Ichthyophthirius resistance can be accomplished in Channel Catfish by either cecropin transgenesis or interspecific hybridization. In addition to survival rate, improving survival time is important because the extension of survival time provides greater opportunity to apply treatments to stop the protozoan infestation.
    Type of Medium: Online Resource
    ISSN: 1522-2055 , 1548-8454
    URL: Issue
    URL: Article
    DOI: 10.1002/naaq.2019.81.issue-3
    DOI: 10.1002/naaq.10096
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2192450-8
    detail.hit.zdb_id: 1482260-X
    SSG: 21,3
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Effects of pomegranate peel and olive pomace supplementation on reproduction and oxidative status of rabbit doe
    Wiley ; 2022
    In:  Journal of Animal Physiology and Animal Nutrition Vol. 106, No. 3 ( 2022-05), p. 655-663
    Details
    In: Journal of Animal Physiology and Animal Nutrition, Wiley, Vol. 106, No. 3 ( 2022-05), p. 655-663
    Abstract: The current study aimed to investigate the effects of pomegranate peel and olive pomace supplementation on the reproductive hormones, antioxidative status, reproductive capacity and maternal behaviour of rabbit does. Forty does were used for the experiments. The animals were randomly assigned to four groups of ten does. One group was fed on the control diet and was considered the control group (C). The second group was supplemented with 4.5% pomegranate peel in their diet (P), the third group was supplemented with 10% olive pomace in their diet (O), and the fourth group was supplemented with a mixture of pomegranate peel and olive pomace (PO). Compared with the control does, group P showed significantly increased serum levels of gonadotropic hormones and oestradiol‐17β two hours after mating, on the 20th day of lactation and after weaning; significantly increased progesterone levels at mid‐pregnancy; and significantly increased in prolactin levels on the 10th day of lactation. Additionally, the results revealed significant increases in total DNA, protein concentration, litter size, milk yield and nest traits of groups P and PO. In conclusion, pomegranate peel supplementation improves the reproductive performance of does and increases their antioxidant parameters.
    Type of Medium: Online Resource
    ISSN: 0931-2439 , 1439-0396
    URL: Issue
    URL: Article
    DOI: 10.1111/jpn.v106.3
    DOI: 10.1111/jpn.13617
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020405-X
    SSG: 12
    SSG: 21
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