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  • 1
    In: Alzheimer's & Dementia, Wiley, Vol. 16, No. S10 ( 2020-12)
    Abstract: Prior research suggests that health systems are unprepared for a potential disease‐modifying treatment (DMT) for Alzheimer’s disease and projected substantial delays in access. We analyzed whether and to what degree changes to institutional arrangements (e.g., policies, incentives and regulations) could improve capacity and readiness in five countries. Method Desk research and expert interviews in France, Germany, Italy, Spain, and the U.K. focusing on planning for and coverage of memory services, ability of providers to adapt to a surge in demand and provider capabilities along the patient journey from diagnosis to treatment. Result No country has a government‐led plan to prepare for the advent of a DMT or advance planning to budget for the expected increase spending. Spain and the U.K. have expert‐led initiatives to inform the policy dialog. Screening for cognitive decline is not recommended or covered in any of the countries. While all cover initial evaluation of memory complaints in primary care settings, it is often not performed because of limited knowledge, lack of tools and fatalistic attitude. Patients with suspected cognitive decline have access to specialist memory services in all five countries, led by geriatric psychiatrists (Germany and U.K.) or neurologists (France, Italy and Spain). Scale and scope vary substantially within and across countries, with only France and the U.K. attempting to standardize services. Only Italy and Spain cover biomarker testing based on PET scans or CSF tests for routine care. Memory services operate at capacity in all countries with wait times of at least two months, and limited flexibility to scale up due to low numbers of dementia specialists, lack of budget and complex planning processes. Psychiatry‐led services tend to be less prepared for the medicalized requirements of a DMT delivery. Conclusion Institutional preparedness and funding for a DMT needs to be improved in all five countries, particularly by strengthening primary care with training and tools, such as simple cognitive tests and blood‐based tests for Alzheimer’s biomarkers, as workforce and budget constraints limit the ability to scale up specialist services. Such improvements would also improve access to and quality of memory care in the absence of a DMT.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2201940-6
    Location Call Number Limitation Availability
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2003
    In:  Acta hydrochimica et hydrobiologica Vol. 31, No. 4-5 ( 2003-12), p. 297-306
    In: Acta hydrochimica et hydrobiologica, Wiley, Vol. 31, No. 4-5 ( 2003-12), p. 297-306
    Abstract: Freie und partikelassoziierte extrazelluläre Enzymaktivität und bakterielle Produktion im unteren Elbeästuar, Deutschland Hohe Abundanzen von Partikeln und Aggregaten sind für Ästuare charakteristisch, und ihre Textur und Oberflächen können wichtige Orte für eine gesteigerte Bioproduktivität und mikrobielle Aktivität repräsentieren. Von einer im Elbeästuar durchgeführten Studie wurden Partikelanzahl und ‐größenverteilung (Partikelzähler), Abundanz und Biomasse von Bakterien (AODC‐Methode), bakterielle Produktionsraten ([ 3 H] Thymidin‐Methode) und mikrobielle extrazelluläre Enzymaktivitäten (MUF‐ und MCA‐Methode) mit spezieller Hinsicht auf ihre Beziehung zu Partikeln und Aggregaten (Größenfraktionierung) untersucht. Obwohl im Vergleich zu anderen Flussabschnitten der Elbe eine höhere Partikelabundanz vorgefunden wurde, konnte keine relativ oder — mit Ausnahme der meisten Peptidasen, Galactosidasen und der Phosphatase — absolut erhöhte bakterielle Aktivität, assoziiert mit Partikeln und Aggregaten, bestimmt werden. Für den Abbau des organischen Materials war hauptsächlich die Aktivität der freien gelösten mikrobiellen Enzyme verantwortlich. Die Produktivität der freien Bakterien (≥0.2… 〈 2 μm, 2…69%) und der an kleine Partikel angehefteten Bakterien ( 2… 〈 10 μm, 27…93%) übertraf deutlich die bakterielle Produktion an Partikeln 〉 10 μm (0…40%). Damit konnte gezeigt werden, dass Partikel und Aggregate nicht zu allen Zeiten in Fließgewässern und Ästuaren substantiell zur mikrobiellen Gesamtaktivität beitragen.
    Type of Medium: Online Resource
    ISSN: 0323-4320 , 1521-401X
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 2270984-8
    detail.hit.zdb_id: 1480781-6
    detail.hit.zdb_id: 7185-7
    SSG: 13
    SSG: 14
    Location Call Number Limitation Availability
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