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  • Vietnam National University Journal of Science  (8)
  • 1
    Online Resource
    Online Resource
    Flos Lonicerae: A Review of Chemical Structures and Biological Activities of Phenolic Derivatives
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 38, No. 4 ( 2022-12-18)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 38, No. 4 ( 2022-12-18)
    Abstract: Flos Lonicerae, a widely used Vietnamese medicinal material, is the dried buds or flowers of Lonicera japonica Thunb., and several other species of genus Lonicera such as Lonicera dasystyla Rehd., Lonicera confusa DC., Lonicera cambodiana Pierre ex Danguy, belonging to the family Caprifoliaceae. This material has been used for a long time in traditional medicine for clearing heat, removing toxins, and dispersing wind heat. According to a variety of recent phytochemistry and biological studies that we systematically summarized, Flos Lonicerae contains 129 phenolic derivatives including 48 flavonoids, 13 lignans and neolignans, 55 phenolic acid derivatives, and 13 other phenolic compounds. These phenolic compounds have remarkable biological effects such as antibacterial, antiviral, antioxidant, anti-inflammatory, anti-cancer, hepatoprotective, anti-endotoxin, anti-allergic, anti-diabetic, cardioprotective, anti-allergic activities, etc. In particular, chlorogenic acid, a prominent component with significant biological activities, is utilized as a marker compound to evaluate the quality of Flos Lonicerae in the Vietnamese and Chinese Pharmacopoeia.      
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4429
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Simultaneous Quantification of Kirenol, Daurutoside, and Darutigenol in Siegesbeckia orientalis L. by HLPC-DPA Method
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 38, No. 2 ( 2022-06-24)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 38, No. 2 ( 2022-06-24)
    Abstract: Kirenol (1), darutoside (2), and darutigenol (3), which are major active diterpenoids isolated from Herba Siegesbeckiae, are reported for analgesic activity and inflammatory effects. Currently, in Vietnamese Pharmacopoeia V, there is no requirement for the contents of active ingredients in this medicinal plant. In this study, a high-performance liquid chromatography (HPLC) method, which was developed with good repeatability and recovery, was used for simultaneous quantification of 1, 2, and 3 in Herba Siegesbeckiae. This method was successfully applied to quantify 1-3 in samples of Herba Siegesbeckiae collected from different locations. The results showed that the content of compound 1 accounted for 0 – 5.77 mg/g, compound 2 ranged from 0.82 to 5.48 mg/g, and compound 3 ranged from 0.37 to 3.18 mg/g. These results are considered a reference for upgrading the specification and quality control of Herba Siegesbeckiae. Keywords: Herba Siegesbeckiae; kirenol; darutoside; darutigenol; HPLC.    
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4399
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 3
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    Online Resource
    Evaluation on the Stability of Amine-Mesoporous Silica Adsorbents used for CO2 Capture
    Vietnam National University Journal of Science ; 2020
    In:  VNU Journal of Science: Earth and Environmental Sciences Vol. 36, No. 1 ( 2020-03-13)
    Details
    In: VNU Journal of Science: Earth and Environmental Sciences, Vietnam National University Journal of Science, Vol. 36, No. 1 ( 2020-03-13)
    Abstract: Amine-mesoporous silica has been considered as a promising CO2 adsorbent with high potential for the reduction of energy consumption and CO2 capture cost; however, its stability could greatly vary with synthetic method. In this study, adsorbents prepared by impregnating different amines including polyethylenimine (PEI) and 3-aminopropyltriethoxysilane (APTES) onto mesoporous silica were used to evaluate the effect of amines selection on the stability of adsorbents used in CO2 capture process. Results revealed that APTES impregnated mesoporous silica (APTES-MPS) is more stable than PEI-impregnated mesoporous silica (PEI-MPS); APTES-MPS was thermally decomposed at ≈280 oC, while PEI-MPS was thermally decomposed at ≈180 oC only. PEI-MPS was particularly less stable when operating under dry condition; its CO2 adsorption capacity reduced by 22.1% after 10 adsorption/regeneration cycles, however, the capacity can be significantly improved in humid condition. APTES-MPS showed a greater stability with no significant reduction in CO2 capture capacity after 10 adsorption/regeneration cycles. In general, APTES-MPS adsorbent possesses a higher stability compared to PEI-MPS thanks to the formation of chemical bonds between amino-functional groups and mesoporous silica substrate. Keywords: Mesoporous silica; CO2 capture; Adsorption; Regeneration; Emission.
    Type of Medium: Online Resource
    ISSN: 2588-1094 , 2615-9279
    URL: Article
    DOI: 10.25073/2588-1094/vnuees.4549
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2020
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  • 4
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    Online Resource
    Preparation of Berberine Chloride Nanoparticles by Ball Milling Method
    Vietnam National University Journal of Science ; 2022
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 38, No. 4 ( 2022-12-18)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 38, No. 4 ( 2022-12-18)
    Abstract: Berberine is a quaternary benzylisoquinoline alkaloid that has been used for the local treatment of gastrointestinal tract diseases. Recently, several pharmacological effects of berberine have been reported, which include anti-hypertension, antitumor, anti-hypercholesterolemia, and neuroprotective effects. However, berberine has exhibited poor aqueous solubility and low oral bioavailability. To overcome these limitations, this study aims to develop and investigate nano berberine. Nano berberine fabricated by ball milling method is a simple process and easily applied in the production scale. The characterization of nano berberine was evaluated, including appearance, particle size, potential zeta, dissolution in vitro in a phosphate buffer media (pH 6.8), differential scanning calorimetry (DSC) analysis, fourier transformed infrared spectroscopy (FTIR), and X-ray diffraction analysis (XRD). Results from this study showed that spray-dried nano berberine powder was almost uniform in size, particle size average of 570.7 nm, and potential zeta of -28.6 mV. The dissolution in vitro study revealed that nano berberine was about 2 times more soluble than raw berberine for 60 minutes. No incompatibility between drug and excipients can be observed through FTIR and DSC analysis. XRD analysis suggested that raw berberine and nano berberine might exist in a crystal form. Thus, findings from this study indicate that the physicochemical properties of spray-dried nano berberine may increase the bioavailability of oral berberine.  
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4437
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2022
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  • 5
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    Online Resource
    Evaluation of Protein Kinase C Inhibition of some Benzofuro[3,2-d]pyrimidine Derivatives
    Vietnam National University Journal of Science ; 2023
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 39, No. 1 ( 2023-03-25)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 39, No. 1 ( 2023-03-25)
    Abstract: Abstract: Treatment of fungal infections is very difficult because of the limited therapeutic arsenal and the emergence of resistance to the two major antifungal classes: azoles and echinocandins. Consequently, finding new targets and new therapeutic strategies is a priority. The protein kinase Pkc1 of Candida albicans (CaPkc1), one of the key proteins involved in MAPK pathways, is described as a regulator of cell wall integrity during growth, morphogenesis, and response to cell wall stress. Therefore, the discovery of CaPkc1 inhibitory molecules can open up new and promising prospects in the development of new antifungal drugs that inhibit CaPkc1. In this study, we evaluated the CaPkc1 inhibitory activity of three benzofuro[3,2-d]pyrimidine derivatives at three different concentrations of 50 µM, 100 µM, and 150 µM. A concentration of 100 μM was optimal for CaPkc1 inhibitory activity with all three benzofuro[3,2-d]pyrimidine derivatives. Keywords: Benzofuro[3,2-d]pyrimidine, CaPkc1, Candida albicans, antifungal activity.     
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4493
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    New Feature Selection Method for Multi-channel EEG Epileptic Spike Detection System
    Vietnam National University Journal of Science ; 2019
    In:  VNU Journal of Science: Computer Science and Communication Engineering Vol. 35, No. 2 ( 2019-12-24)
    Details
    In: VNU Journal of Science: Computer Science and Communication Engineering, Vietnam National University Journal of Science, Vol. 35, No. 2 ( 2019-12-24)
    Abstract: Epilepsy is one of the most common and severe brain disorders. Electroencephalogram (EEG) is widely used in epilepsy diagnosis and treatment, with it the epileptic spikes can be observed. Tensor decomposition-based feature extraction has been proposed to facilitate automatic detection of EEG epileptic spikes. However, tensor decomposition may still result in a large number of features which are considered negligible in determining expected output performance. We proposed a new feature selection method that combines the Fisher score and p-value feature selection methods to rank the features by using the longest common sequences (LCS) to separate epileptic and non-epileptic spikes. The proposed method significantly outperformed several state-of-the-art feature selection methods.
    Type of Medium: Online Resource
    ISSN: 2588-1086 , 2615-9260
    URL: Article
    DOI: 10.25073/2588-1086/vnucsce.230
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2019
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  • 7
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    Online Resource
    Simultaneous Quantification of Acid chlorogenic, Acid caffeic and Rutin in Herba Siegesbeckiae orientalis by HLPC Method
    Vietnam National University Journal of Science ; 2023
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 39, No. 2 ( 2023-06-20)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 39, No. 2 ( 2023-06-20)
    Abstract: Herba Siegesbeckiae is a medicinal material derived from the aerial part of Siegesbeckia orientalis, which is used to treat various types of pain such as back, knees, bones, joints, and numbness of limbs. This plant contains several phenolic compounds, including chlorogenic acid (1), caffeic acid (2), and rutin (3). They were chosen as marker compounds to develop a quantification method. In this study, a high-performance liquid chromatography (HPLC) method with a DAD detector was used to simultaneously quantify these three compounds (1-3). The Agilent C18 column (250 x 4.6 mm; 5 µm) was used for the separation of the analytes, and the mobile phase consisted of MeCN - 0.1% phosphoric acid in water with gradient elution. The flow rate was 1.0 ml/min, and the detection wavelength was 320 nm for 1 and 2, and 360 nm for 3. The injection volume was 20 µl. The method was validated according to the guidelines of ICH and AOAC on system suitability, specificity, linearity, precision, and accuracy. The established quantification method was applied to determine the content of compounds 1, 2, and 3 in samples of Herba Siegesbeckiae, which were found to be 0.09-0.82 mg/g, 0.02-0.21 mg/g, 0.07-0.52 mg/g, respectively. This quantification method can be used to assess the quality of Herba Siegesbeckiae and related products.
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4522
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2023
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  • 8
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    Online Resource
    Development of an HPLC Method for Simultaneous Quantification of Rosmarinic Acid, Sinensetin in Herba Orthosiphonis spiralis
    Vietnam National University Journal of Science ; 2023
    In:  VNU Journal of Science: Medical and Pharmaceutical Sciences Vol. 39, No. 2 ( 2023-06-21)
    Details
    In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 39, No. 2 ( 2023-06-21)
    Abstract: The purpose of this study was to develop an HPLC method for the simultaneous quantification of rosmarinic acid and sinensetin in Herba Orthosiphonis spiralis. The chromatographic separation was performed on an Ascentis®C8 column (250 × 4.6 mm, 5 µm) using a gradient elution mode with acetonitrile and water containing 0.1% formic acid as mobile phase. The flow rate was maintained at 0.6 mL/min. The injection volume was 10 mL. The column temperature was set at 40 °C. Analytes were detected by a PDA detector at a wavelength of 329 nm. The method was validated for specificity, system suitability, linearity, accuracy, precision, detection limit, and quantitation limit according to ICH and AOAC. The results of validation showed that the method met all the acceptance criteria and was suitable for simultaneous quantification of rosmarinic acid and sinensetin in Herba Orthosiphonis spiralis.
    Type of Medium: Online Resource
    ISSN: 2588-1132 , 2615-9309
    URL: Article
    DOI: 10.25073/2588-1132/vnumps.4505
    Language: Unknown
    Publisher: Vietnam National University Journal of Science
    Publication Date: 2023
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