GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Berlin :Erich Schmidt Verlag,  (1)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (1)
  • 1
    Online-Ressource
    Online-Ressource
    Berlin :Erich Schmidt Verlag,
    Schlagwort(e): Tourism. ; Economic development. ; Electronic books.
    Beschreibung / Inhaltsverzeichnis: Global imbalances and crises which occurred more frequently and at shorter intervals made international tourism demand more volatile. This book, edited by Peter Keller and Thomas Bieger, provides a unique analysis of the recent financial crisis on world tourism and particularly the development models which contribute to reduce poverty. The volume is based on the knowledge of a network of more than 300 researches and includes experiences from Europe, Africa and Asia. It focuses on the latest economic crises as a framework for analyses and as a real life case study. Reihe International Tourism Research and Concepts - Band 05.
    Materialart: Online-Ressource
    Seiten: 1 online resource (262 pages)
    Ausgabe: 1st ed.
    ISBN: 9783503130047
    Serie: International Tourism Research and Concepts ; v.5
    DDC: 333.88
    Sprache: Englisch
    Anmerkung: Front Cover -- Front Matter -- Foreword -- Table of Contents -- Introduction -- Section 1: Impact of Global Economics Imbalances and Crises on World Tourism -- How International Tourism is Coping with the Consequences of the Financial and Economic Crisis -- Post Crisis Forecast of Tourist Arrivals - Asia Pacific -- The Impact of Global Economic Recession on Tourism SMMEs in South Africa -- Potential of the Tourism Confidence Index in the Circumstances of Economic Crisis -- Regional Differences of Strategies towards Crises in Tourism -- Section 2: Lessons to be Learnt for FutureTourism Development in Poor Regions -- Skills and Tourism Facilities in a Poverty Context: The Role of a NGO in the Peruvian Andes -- Linkage between Operators' Satisfaction and Local Resource Potential for Rural Tourism -- Venture Capital Financing and Tourism Industry in South Africa -- Technical Cooperation as a Driver for Destination Development? - Two Cases from India -- Section 3: Strategic Approaches for Developing Tourism Destinations -- Tourism a Vehicle of Development? - A Regional Approach -- Can Community-Based Tourism Trigger Poverty Reduction - a Case Study from Kenya -- Tourism and Poverty Alleviation Approaches: A Case Study Comparison -- Twenty Years of Tourism Development Research: A Strategic Market Forces Perspective -- List of Authors -- Back Cover.
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Publikationsdatum: 2017-04-01
    Beschreibung: Diverse protein import pathways into mitochondria use translocons on the outer membrane (TOM) and inner membrane (TIM). We adapted a genetic screen, based on Ura3 mistargeting from mitochondria to the cytosol, to identify small molecules that attenuated protein import. Small molecule mitochondrial import blockers of the Carla Koehler laboratory (MB)-10 inhibited import of substrates that require the TIM23 translocon. Mutational analysis coupled with molecular docking and molecular dynamics modeling revealed that MB-10 binds to a specific pocket in the C-terminal domain of Tim44 of the protein-associated motor (PAM) complex. This region was proposed to anchor Tim44 to the membrane, but biochemical studies with MB-10 show that this region is required for binding to the translocating precursor and binding to mtHsp70 in low ATP conditions. This study also supports a direct role for the PAM complex in the import of substrates that are laterally sorted to the inner membrane, as well as the mitochondrial matrix. Thus, MB-10 is the first small molecule modulator to attenuate PAM complex activity, likely through binding to the C-terminal region of Tim44.
    Print ISSN: 0021-9258
    Digitale ISSN: 1083-351X
    Thema: Biologie , Chemie und Pharmazie
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...