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  • 1
    Electronic Resource
    Electronic Resource
    Nonlinear Optical Interactions in Bacteriorhodopsin Using Z-Scan (1995)
    Springer
    Optical review 2 (1995), S. 204-206 
    Details
    ISSN: 1349-9432
    Keywords: bacteriorhodopsin ; Z-scan ; nonlinear ; optics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Nonlinear refractive index coefficient n2 of bacteriorhodopsin suspensions in water is measured by the Z-scan technique with a low power continuous wave laser at 647.1 manometer wavelength. Our results indicate that both the magnitude and the sign of n2 depend strongly on the light intensity. Negative values for n2 are obtained for on axis laser irradiance at the focus above 3 W/cm2. The observed self-defocusing phenomena can be attributed to the index change due to the light induced transition between the photochromic states. The results elucidate the origin of n2 and offer a plausible explanation for the differences in the reported n2 measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10043-995-0204-x
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  • 2
    Electronic Resource
    Electronic Resource
    Progress in limb and digital replantation: Part a—Introduction (1990)
    Springer
    World journal of surgery 14 (1990), S. 804-806 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01670527
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  • 3
    Electronic Resource
    Electronic Resource
    Reconstruction of the thumb and digit by toe to hand transplantation (1991)
    Springer
    World journal of surgery 15 (1991), S. 429-438 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé En raison du développement rapide de la microchirurgie, il est possible de réimplanter la plupart des doigts amputés. Chez certains patients, cependant, le traumatisme est tellement important qu'aucune réimplantation ne peut être tentée: dans les accidents par écrasement ou les lésions par “souffle” dans lesquelles la partie amputée est abîmée ou fracasée. Il existe de nombreuses méthodes pour reconstruire un pouce ou un doigt. Les procédés que nous employons dans notre Hôpital sont: (1) pour le pouce, le transfert du deuxième orteil, le lambeau unguéal du gros orteil avec greffon osseux, le lambeau unguéal et le transfert osseux du deuxième orteil; (2) pour les autres doigts, le transfert du deuxième orteil, seul ou combiné avec celui du troisième; (3) pour la main, le transfert bi ou unilatéral du deuxième orteil; et (4) des prothèses de main à visée esthétique.
    Abstract: Resumen Gracias al rápido desarrollo de la microcirugía, actualmente es factible reimplantar la mayor parte de los pulgares y los dedos de la mano que hay an sido amputados. Sin embargo, en ciertos pacientes el trauma es tan severo que la reimplantación no puede ser realizada, tal como ocurre con las lesiones por aplastamiento o por explosión, donde la parte amputada resulta severamente aplastada o fragmentada en pedazos. Existen muchos métodos de reconstrucción; los siguientes son los utilizados en nuestro hospital.
    Notes: Abstract Since the rapid development of microsurgery it is feasible to replant most severed thumbs and digits. In certain patients, however, the trauma is so severe that replantation cannot be performed, such as crush or burst injuries where the amputated part is badly smashed or broken into pieces. There are many methods used to reconstruct amputated thumbs or digits. In our hospital reconstruction of the thumb is accomplished by second toe transplantation, nail flap of the great toe transplantation and bone graft, and nail flap of the great toe and skeleton from the second toe transplantation. Reconstruction of fingers is undertaken through second toe transplantation and second and third toe transplantation. After total loss of the hand, double second toe transplant is used for reconstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01675637
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  • 4
    Electronic Resource
    Electronic Resource
    Metastastic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction (1997)
    Springer
    Clinical & experimental metastasis 15 (1997), S. 527-537 
    Details
    ISSN: 1573-7276
    Keywords: metastasis ; squamous cell carcinoma ; tumor progression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to develop an experimental model of squamous cell carcinoma that can be used to identify molecular and immunologic changes associated with primary events in malignant transformation, and those associated with metastatic tumor progression in the presence of host homeostatic and immunologic factors. Metastatic variants were derived following in vivo tumor progression of the in vitro transformed squamous cell carcinoma line Pam 212. The parental and metastatic cell lines exhibited similar morphologic features and molecular markers of an epithelial lineage, including an epithelial morphology in culture, cell surface expression of integrin α6β4, and expression of mRNA of cytokeratins K6 and K14. When the growth and metastatic phenotype of the parental and reisolate cell lines was compared, the reisolate cell lines were found to exhibit a greater rate of growth and incidence of metastasis than the parental cell line when reimplanted in vivo. The difference in the growth rate of the parental cell line and the variants observed in vivo was not detected when growth of these lines was compared in vitro, suggesting that the growth advantage and selection of these variants requires tumor-host interaction. The metastatic variants exhibited a similar growth advantage in normal immunocompetent and SCID Balb/c mice, indicating that the growth advantage in vivo is not due to T or B lymphocyte-dependent immune factor(s). We conclude that metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line exhibit a differential growth advantage in vivo that requires the host environment. Comparison of these in vitro transformed and in vivo derived metastatic variant cell lines with phenotypic differences in growth and metastasis should prove useful for dissecting the role of tumor and host factor(s) in malignant transformation and metastatic tumor progression of squamous cell carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018474910432
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  • 5
    Electronic Resource
    Electronic Resource
    The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC (1998)
    Springer
    Clinical & experimental metastasis 16 (1998), S. 655-664 
    Details
    ISSN: 1573-7276
    Keywords: proinflammatory cytokines ; IL-1a ; IL-6 ; IL-8 and GM-CSF ; squamous cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human and murine squamous cell carcinomas (SCC) have been reported to produce proinflammatory cytokines IL-1a, IL-6, GM-CSF, and IL-8 or KC. Production of individual members of the proinflammatory cytokine family has been associated with increased tumor growth or metastasis in a variety of neoplasms. In this study, we determined whether the expression of these cytokines occurs as a result of the events of cel-lular transformation or culture, or is promoted by interaction of neoplastic cells with factors or cells in the host environment. We compared the expression of proinflammatory cytokines following the spontaneous transformation of murine keratinocytes in vitro, and following the formation of tumors and metastases from these transformed keratinocytes in syngeneic recipients in vivo. Using sensitive ELISA assays, we found that cultures of the in vitro transformed Balb/c SCC line Pam 212 do not produce elevated levels of proinflam-matory cytokines IL-1a, IL-6, GM-CSF and KC, indicating that transformation or culture alone is insufficient to account for the level of cytokine expression detected in patient and experimental tumors. In contrast, Pam reisolates from primary and metastatic tumors were obtained which constitutively produce markedly elevated levels of cytokines IL-1a, IL-6, KC and GM-CSF. The increase in the expression of these cytokines by SCC in vivo occurred independent of T and B lymphocyte-mediated immunity, since increases in expression of the cytokines was observed in lines reisolated from immunodeficient athymic nude and SCID Balb/c congenic mice. The increased expression of cytokines appeared to result from additional events in vivo, rather than due to selection of a pre-existing cytokine-producing subpopulation, since clones of the parental cell line expressed lower cytokine levels than cloned reisolates, and clones of the non-secreting parental cell line that formed tumors in vivo secreted elevated levels of cytokines following reisolation. We conclude that the development of SCC that express proinflammatory cytokines is promoted by tumor-host interaction(s) that are independent of specific T and B cell immunity©Lippincott Williams & Wilkins
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006559811429
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  • 6
    Electronic Resource
    Electronic Resource
    Three-graviton vertex calculation and divergence analysis of higher-derivative quantum gravity (1997)
    Springer
    International journal of theoretical physics 36 (1997), S. 2839-2845 
    Details
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Higher-derivative contributions to the three-graviton vertex are calculated for 4-derivative quantum gravity, and its divergence is analyzed. It is shown that new divergences exist in the theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02435712
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  • 7
    Electronic Resource
    Electronic Resource
    Cobalt (iron) thiolato complexes containing the Co-ligand phosphine and reaction products of the structural fragment ML 2 L′ (L = 1,2-bidentate thiolate,L′= tertiary phosphine) (1996)
    Springer
    Journal of cluster science 7 (1996), S. 317-340 
    Details
    ISSN: 1572-8862
    Keywords: Cobalt (iron) complexes ; thiolate ; phosphine ; structure ; synergism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Mono-, di-, tri-, and tetra-nuclear cobalt (iron) complexes containing co-ligands phosphine and thiolate are presented according to the classification by combination of different dentates of the two ligands. Emphasis is being put on the triand tetranuclear cluster complexes of monodentate phosphines and 1,2-bidentate thiolates. These complexes are considered to be constructed based on the general structural fragment (or building block) ML 2L′ (L=1,2-bidentate thiolate,L′=tertiary phosphine). Structural regularities are presented in Tables I, III, IV, and V and discussed. FAB mass spectroscopic data showed the possible fragmentation patterns. Synergism of the cluster skeletons is proposed to explain the occurrence of the distinct structural modes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01171186
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  • 8
    Electronic Resource
    Electronic Resource
    Enhanced Antitumor Activity of SarCNU in Comparison to BCNU in an Extraneuronal Monoamine Transporter Positive Human Glioma Xenograft Model (1999)
    Springer
    Journal of neuro-oncology 44 (1999), S. 7-14 
    Details
    ISSN: 1573-7373
    Keywords: extraneuronal monoamine transporter ; glioma ; SarCNU ; xenograft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A novel analogue of nitrosoureas, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), has demonstrated increased anticancer effects in vitro and in vivo. Our previous work suggested that SarCNU enters cells via the extraneuronal monoamine transporter (EMT), that contributes to its enhanced cytotoxicity. In the present study, comparative activities of SarCNU and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) were evaluated in an EMT positive human glioma xenograft model. Athymic nude mice implanted subcutaneously or intracranially with human glioma SHG-44, a cell line that has been confirmed EMT positive by using reverse-transcription polymerase chain reaction (RT-PCR) assay, were treated with SarCNU at an optimal dose of 167 mg/kg, or BCNU at 20 mg/kg or 30 mg/kg, q4d×3 intraperitoneally (i.p.). In 17 animals with subcutaneous tumor grafts treated with SarCNU, 9 animals became tumor free and 8 demonstrated tumor regression. While in the BCNU treated group, there were only 2 out of 10 mice in the 20 mg/kg group and 2 out of 7 in the 30 mg/kg group, which demonstrated some tumor regression. There were 4 drug related deaths in the BCNU (30 mg/kg) group, while there were no drug related deaths in the SarCNU group. In the intracranially implanted mice, the median survival time in the SarCNU group was more than 130 days, while in the BCNU treated group it was only 22 days which was similar to the control group (18 days). This is the first demonstration that SarCNU, in comparison to BCNU, has enhanced anticancer activity in an EMT positive human glioma xenograft model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006245724456
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  • 9
    Electronic Resource
    Electronic Resource
    2D hexagonal grids assembled into 3D nets via Ag···Ag interactions (1999)
    Springer
    Journal of chemical crystallography 29 (1999), S. 1239-1243 
    Details
    ISSN: 1572-8854
    Keywords: cyanide bridge ; Ag···Ag interaction ; three-dimensional structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A three-dimensional coordination polymer [Ni(en)2Ag3(CN)5]n (en = 1,2-diaminoethane) was synthesized and characterized by X-ray crystallography. It crystallizes in the triclinic space group $$P\bar 1$$ ,a = 7.520(2) Å, b = 8.194(2) Å, c = 8.426(2) Å, α = 65.35(3)°, β = 69.57(3)°, γ = 68.91(3)°, V = 428.0(2), Å3 Z = 1. The 2D hexagonal grids are constructed using cyanides as bridges, and the Ag···Ag interactions between layers lead to a three-dimensional network.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009548705677
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  • 10
    Electronic Resource
    Electronic Resource
    Integrity and Structural Characteristics of the M6E8 (E=S, Se, Te) Cluster Core: Syntheses and Structures of [Co6S8(PR3)6] n+ (R=Me2Ph, n=1; R=OMe, n=0) (1999)
    Springer
    Journal of cluster science 10 (1999), S. 429-443 
    Details
    ISSN: 1572-8862
    Keywords: Cluster core M6E8 ; structural characteristics ; crystal structure ; hexacobalt cluster complex ; phosphine ; sulfide bridging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Two new members of the hexanuclear series [Co6S8(PR3)6] n+, complexes [Co6S8(PMe2Ph)6](ClO4) (1) and [Co6S8P(OMe)3 6] (2), have been synthesizes and characterized by X-ray diffraction analyses. Their formation process was postulated to go through trinuclear μ3--S bridged moieties. The structural characteristics of the M6E8P6 skeleton of a whole series of [M6E8(PR3)6] n+ (M=Co, Cr, Fe, Mo; E=S, Se, Te) complexes are presented in terms of atomic distances and core volumes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022681127451
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