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  • 1
    In: Veterinary Pathology, SAGE Publications, Vol. 44, No. 4 ( 2007-07), p. 467-478
    Kurzfassung: The significance of p16/Rb tumor suppressor pathway inactivation in T-cell non-Hodgkin's lymphoma (NHL) remains incompletely understood. We used naturally occurring canine NHL to test the hypothesis that p16 inactivation has specific pathologic correlates. Forty-eight samples (22 T-cell NHL and 26 B-cell NHL) were included. As applicable, metaphase- or array-based comparative genomic hybridization, Southern blotting, promoter methylation, and Rb phosphorylation were used to determine the presence, expression, and activity of p16. Fisher's exact test was used to test for significance. Deletion of p16 (or loss of dog chromosome 11) was restricted to high-grade T-cell NHL (lymphoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified). These were characterized by a concomitant increase of tumor cells with Rb phosphorylation at canonical CDK4 sites. Rb phosphorylation also was seen in high-grade B-cell NHL (diffuse large B-cell lymphoma and Burkitt-type lymphoma), but in those cases, it appeared to be associated with c-Myc overexpression. The data show that p16 deletion or inactivation occurs almost exclusively in high-grade T-cell NHL; however, alternative pathways can generate functional phenotypes of Rb deficiency in low-grade T-cell NHL and in high-grade B-cell NHL. Both morphologic classification according to World Health Organization criteria and assessment of Rb phosphorylation are prognostically valuable parameters for canine NHL.
    Materialart: Online-Ressource
    ISSN: 0300-9858 , 1544-2217
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2007
    ZDB Id: 2106608-5
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 11, No. 2_suppl ( 2005-12), p. 29-34
    Materialart: Online-Ressource
    ISSN: 1357-633X , 1758-1109
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2005
    ZDB Id: 2007700-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 1985
    In:  Experimental Biology and Medicine Vol. 180, No. 3 ( 1985-12-01), p. 497-504
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 180, No. 3 ( 1985-12-01), p. 497-504
    Materialart: Online-Ressource
    ISSN: 1535-3702 , 1535-3699
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1985
    ZDB Id: 2020856-X
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 11, No. 1_suppl ( 2005-07), p. 71-73
    Kurzfassung: Multidisciplinary team (MDT) meetings for decisions on cancer management are a cornerstone of UK cancer policy. We have proposed a comprehensive methodology to assess the clinical and economic effectiveness of telemedicine in this setting, which is being tested in a randomized breast cancer trial. Pre- and post-telemedicine assessment includes attitudes to and expectations of telemedicine, based on semistructured interviews. The communication content of videotapes of the MDT meeting is being scored using Borgatta's revised Interaction Process Analysis System. The technical performance of the telemedicine equipment is reported on a standardized pro forma. A short questionnaire captures key elements of professional satisfaction for each patient discussion (consensus on future management, confidence in and sharing of decision), added value of linkage, group atmosphere, overall conduct of the meeting and compliance with SIGN guidelines. A cost-minimization analysis will be used for economic assessment.
    Materialart: Online-Ressource
    ISSN: 1357-633X , 1758-1109
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2005
    ZDB Id: 2007700-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    In: Journal of Cross-Cultural Psychology, SAGE Publications, Vol. 45, No. 2 ( 2014-02), p. 213-245
    Kurzfassung: The construct of individualism–collectivism (IND-COL) has become the definitive standard in cross-cultural psychology, management, and related fields. It is also among the most controversial, in particular, with regard to the ambiguity of its dimensionality: Some view IND and COL as the opposites of a single continuum, whereas others argue that the two are independent constructs. We explored the issue through seven different tests using original individual-level data from 50 studies and meta-analytic data from 149 empirical publications yielding a total of 295 sample-level observations that were collected using six established instruments for assessing IND and COL as separate constructs. Results indicated that the dimensionality of IND-COL may depend on (a) the specific instrument used to collect the data, (b) the sample characteristics and the cultural region from which the data were collected, and (c) the level of analysis. We also review inconsistencies, deficiencies, and challenges of conceptualizing IND-COL and provide guidelines for developing and selecting instruments for measuring the construct, and for reporting and meta-analyzing results from this line of research.
    Materialart: Online-Ressource
    ISSN: 0022-0221 , 1552-5422
    RVK:
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2014
    ZDB Id: 2021892-8
    SSG: 0
    SSG: 5,2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    In: Lupus, SAGE Publications, Vol. 29, No. 5 ( 2020-04), p. 474-481
    Kurzfassung: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Approximately 15–20% of patients develop symptoms before their 18th birthday and are diagnosed with juvenile-onset SLE (JSLE). Gender distribution, clinical presentation, disease courses and outcomes vary significantly between JSLE patients and individuals with adult-onset SLE. This study aimed to identify age-specific clinical and/or serological patterns in JSLE patients enrolled to the UK JSLE Cohort Study. Methods Patient records were accessed and grouped based on age at disease-onset: pre-pubertal (≤7 years), peri-pubertal (8–13 years) and adolescent (14–18 years). The presence of American College of Rheumatology (ACR) classification criteria, laboratory results, disease activity [British Isles Lupus Assessment Group (BILAG) and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2 K) scores] and damage [Systemic Lupus International Collaborating Clinics (SLICC) damage index] were evaluated at diagnosis and last follow up. Results A total of 418 JSLE patients were included in this study: 43 (10.3%) with pre-pubertal disease onset; 240 (57.4%) with peri-pubertal onset and 135 (32.3%) were diagnosed during adolescence. At diagnosis, adolescent JSLE patients presented with a higher number of ACR criteria when compared with pre-pubertal and peri-pubertal patients [pBILAG2004 scores: 9(4–20] vs. 7(3–13] vs. 7(3–14], respectively, p = 0.015] with increased activity in the following BILAG domains: mucocutaneous ( p = 0.025), musculoskeletal ( p = 0.029), renal ( p = 0.027) and cardiorespiratory ( p = 0.001). Furthermore, adolescent JSLE patients were more frequently ANA-positive ( p = 0.034) and exhibited higher anti-dsDNA titres ( p = 0.001). Pre-pubertal individuals less frequently presented with leukopenia ( p = 0.002), thrombocytopenia ( p = 0.004) or low complement ( p = 0.002) when compared with other age groups. No differences were identified in disease activity (pBILAG2004 score), damage (SLICC damage index) and the number of ACR criteria fulfilled at last follow up. Conclusions Disease presentations and laboratory findings vary significantly between age groups within a national cohort of JSLE patients. Patients diagnosed during adolescence exhibit greater disease activity and “classic” autoantibody, immune cell and complement patterns when compared with younger patients. This supports the hypothesis that pathomechanisms may vary between patient age groups.
    Materialart: Online-Ressource
    ISSN: 0961-2033 , 1477-0962
    RVK:
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2008035-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    In: Foot & Ankle Specialist, SAGE Publications
    Kurzfassung: Suture buttons and metal screws have been used and compared in biomechanical, radiographic, and clinical outcome studies for syndesmotic injuries, with neither implant demonstrating clear superiority. The aim of this study was to compare clinical outcomes of both implants. Methods Patients who underwent syndesmosis fixation at 2 separate academic centers from 2010 through 2017 were compared. Thirty-one patients treated with a suture button and 21 patients treated with screws were included. Patients in each group were matched by age, sex, and Orthopaedic Trauma Association fracture classification. Tegner Activity Scale (TAS), Foot and Ankle Ability Measure (FAAM), patient satisfaction score, surgical failure, and reoperation rates were compared. Results Patients who underwent suture button fixation had significantly higher TAS scores than those who underwent screw fixation (p 〈 0.001). There was no significant difference in FAAM ADL scores between cohorts (p = 0.08). Symptomatic hardware removal rates were similar (3.2% suture button cohort vs 9.0% in screw cohort). One patient (4.5%) underwent revision surgery secondary to syndesmotic malreduction after screw fixation, for a reoperation rate of 13.5%. Conclusion Patients with unstable syndesmotic injuries treated with suture button fixation had higher mean TAS scores compared to patients treated with screws. Foot and Ankle Ability Measure and ADL scores in these cohorts were similar. Level of Evidence: Level 3 Retrospective Matched Case-Cohort
    Materialart: Online-Ressource
    ISSN: 1938-6400 , 1938-7636
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2023
    ZDB Id: 2411886-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    SAGE Publications ; 2016
    In:  Foot & Ankle International Vol. 37, No. 7 ( 2016-07), p. 748-754
    In: Foot & Ankle International, SAGE Publications, Vol. 37, No. 7 ( 2016-07), p. 748-754
    Kurzfassung: The goal of this study was to objectively assess if rotational or translational syndesmotic malreduction is associated with certain syndesmotic morphologies. Prior studies based on subjective assessment of syndesmotic morphology and reduction have not shown any difference between groups. Methods: Thirty-five prospectively recruited patients with operatively treated syndesmotic injuries were recruited at an Urban Level I Trauma Center. Patients underwent postoperative bilateral computed tomographic (CT) scans of the ankle to assess incisura depth and syndesmotic reduction. The uninjured extremity was used as a control. Side-to-side differences of syndesmotic reduction were measured at several anatomic points and compared to the incisura depth. Results: There was a significant correlation between more shallow syndesmoses and increased anterior translation of the fibula in the incisura ( r = −0.63, P ≤ .001). Six of 8 patients with “shallow” (≤2.5 mm) incisura were anteriorly malreduced greater than or equal to 1.5 mm compared to the contralateral ankle. The anterior malreduction rate in those with a shallow incisura was significantly greater than in the “non-shallow” patients ( P 〈 .001). There were 9 patients with incisurae greater than or equal to 4.5 mm deep. Five of the “deep” patients had posterior malreductions greater than or equal to 1.5 mm. The posterior malreduction rate in the “deep” group was significantly greater than the “non-deep” patients ( P = .02). There was a significant correlation between increasing syndesmotic depth and increased malrotation ( r = .46, P = .01). Conclusion: Syndesmotic morphology was found to be associated with specific malreduction patterns. Shallow syndesmoses were correlated with anterior fibular malreduction, and were less likely to be malrotated. Conversely, deep syndesmoses predisposed to posterior sagittal plane and rotational malalignment. Preoperative CT scans that assess the syndesmosis morphology may allow surgeons to alter reduction strategies to avoid syndesmotic malreduction. Level of Evidence: Level III, retrospective cohort study.
    Materialart: Online-Ressource
    ISSN: 1071-1007 , 1944-7876
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2016
    ZDB Id: 2129503-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    In: Journal of Interpersonal Violence, SAGE Publications, Vol. 36, No. 13-14 ( 2021-07), p. NP7388-NP7414
    Kurzfassung: Once social services steps in to protect children from violence and neglect in their homes, many youth become wards of the specialized juvenile or family court that assists in child protection (e.g., the dependency court). Some of these children will be ordered into foster care. Within this “dependency system,” such children often feel a lack of voice. This study tests the prediction that foster youth who perceive having more opportunity for voice, even indirectly via a representative, more favorably rate the dependency system. Adolescents ( n = 110), aged 17 years, involved in foster care and age-matched nonfoster youth rated “how good or bad the foster care/dependency court is for foster youth.” The foster youth were also asked about their interactions with the court and with their attorney representatives. Foster and nonfoster youth did not significantly differ in dependency system ratings when considered at the overall group level. However, foster and nonfoster youth ratings significantly differed when foster youth’s views of relevant prior legal experiences (e.g., frequency of child–attorney contact, quality of attorney representation) were taken into account: Youth with the highest perceived quality of experiences indicated more positive views than any other group. The importance of perceived quality of experience adds insight into mechanisms for improving adolescents’ feelings of voice in the legal system.
    Materialart: Online-Ressource
    ISSN: 0886-2605 , 1552-6518
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2021
    ZDB Id: 2028900-5
    SSG: 2
    SSG: 2,1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 7, No. 4 ( 2022-10), p. 2473011421S0085-
    Kurzfassung: Ankle Introduction/Purpose: Injuries of the syndesmosis may occur in isolation or association with rotational ankle fractures. The use of suture button 'tight-ropes' versus metal screws for fixation across the syndesmosis has become a highly debated topic. Previous authors have compared subjective, functional, and radiographic outcomes between the two fixation methods with good outcomes reported. The primary aim of this study is to compare clinical outcomes of syndesmotic suture button fixation versus syndesmotic screw fixation for operative management of syndesmotic injuries. A secondary aim is to determine failure rates of both fixation techniques requiring revision syndesmosis surgery. We hypothesize that there will be no difference in subjective outcomes or activity scores when comparing screw versus suture button. This study is to improve patient care and outcomes. Methods: In this multi-center, retrospective cohort study, we identified patients with syndesmotic injuries who underwent surgical treatment at two separate academic referral centers from 2010 through 2017. All patients were diagnosed by attending orthopaedic surgeons at the participating study sites, and where their syndesmotic injuries were treated with either suture-button fixation or metal screw fixation based on surgeon preference. Patients were matched by age, gender, and OTA fracture classification. The primary subjective outcome measure was the Tegner activity level, and the secondary subjective outcomes measures were the Foot and Ankle Ability Measure (FAAM) activities of daily living (ADL) subscale, FAAM sport subscale, and patient satisfaction score. The primary objective outcomes included failure and reoperation rate. Results: 41 patients treated with a suture button (71% male, mean age 39.7 years) and 21 patients treated with metal screws (67% male, mean age 43.7 years) were included in the study. Patient demographics were similar between groups. There was no significant difference in FAAM ADL scores between patients based on surgical procedure for the treatment of a syndesmosis injury (suture button versus metal screw fixation), t (50) = 1.373 (p =0.176). There was a significant difference in Tegner activity scale scores, with patients who underwent suture button fixation reporting significantly higher Tegner activity level scores on average than those who underwent syndesmosis repair with screw fixation (U = 141, p =0.002) (Figure 1). Conclusion: In this multi-center study, we report higher mean Tegner activity scale scores in patients treated with suture button fixation when compared to patients treated with metal screws for unstable syndesmotic injuries. Patients in both treatment cohorts reported similar FAAM ADL scores. The authors believe that both syndesmotic fixation techniques are acceptable in the treatment of syndesmosis of injuries, but recommend consideration given to suture button fixation in patients with higher activity levels.
    Materialart: Online-Ressource
    ISSN: 2473-0114 , 2473-0114
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2022
    ZDB Id: 2874570-X
    Standort Signatur Einschränkungen Verfügbarkeit
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