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  • SAGE Publications  (91)
  • 1
    Online-Ressource
    Online-Ressource
    Uterine Infarctions in Cynomolgus Monkeys ( Macaca fascicularis )
    SAGE Publications ; 2007
    In:  Veterinary Pathology Vol. 44, No. 3 ( 2007-05), p. 309-313
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 44, No. 3 ( 2007-05), p. 309-313
    Kurzfassung: Uterine infarctions have not been reported in domestic animals, and there are few reports in the human medical literature. In a retrospective study, uterine infarctions were identified in 9 of 323 (2.8%) female cynomolgus monkeys ( Macaca fascicularis) necropsied over a 13-year period. The infarctions were grossly visible, after fixation, on the serosal surface of the uterus in 2 monkeys; the remainder were first recognized in histologic sections. Histologically, the lesions consisted of well-demarcated regions of endometrial and myometrial necrosis and of hemorrhage. All affected monkeys had histologic evidence of a previous pregnancy, which included enlarged myometrial vessels with an expanded perivascular matrix. In all monkeys with uterine infarctions, there was clinical evidence of severe systemic illness, which included trauma, diarrhea, hypovolemia, or septicemia. The major pathologic findings in affected monkeys included cutaneous or skeletal muscle necrosis (n = 5), enterocolitis (n = 4), pulmonary edema or diffuse alveolar damage (n = 3), and intestinal amyloidosis (n = 1). Histopathologic evidence of intravascular fibrin thrombi in multiple organs of 5 monkeys was consistent with a diagnosis of disseminated intravascular coagulopathy (DIC). Based on these findings, it appears that uterine infarction is an uncommon finding in cynomolgus monkeys and may occur secondary to a severe systemic illness, predisposing to DIC.
    Materialart: Online-Ressource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1354/vp.44-3-309
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2007
    ZDB Id: 2106608-5
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Anticoagulation, bleeding and blood transfusion practices in Australasian cardiac surgical practice
    SAGE Publications ; 2007
    In:  Anaesthesia and Intensive Care Vol. 35, No. 5 ( 2007-10), p. 760-768
    Details
    In: Anaesthesia and Intensive Care, SAGE Publications, Vol. 35, No. 5 ( 2007-10), p. 760-768
    Kurzfassung: We surveyed contemporary Australasian cardiac surgical and anaesthetic practice, focusing on antiplatelet and antifibrinolytic therapies and blood transfusion practices. The cohort included 499 sequential adult cardiac surgical patients in 12 Australasian teaching hospitals. A total of 282 (57%) patients received red cell or component transfusion. The median (IQR) red cell transfusion threshold haemogloblin levels were 66 (61-73) g/l intraoperative^ and 79 (74-85) g/l postoperatively. Many (40%) patients had aspirin within five days of surgery but this was not associated with blood loss or transfusion; 15% had Clopidogrel within seven days of surgery. In all, 30 patients (6%) required surgical re-exploration for bleeding. Factors associated with transfusion and excessive bleeding include pre-existing renal impairment, preoperative Clopidogrel therapy, and complex or emergency surgery. Despite frequent (67%) use of antifibrinolytic therapy, there was a marked variability in red cell transfusion rates between centres (range 17 to 79%, P 〈 0.001). This suggests opportunities for improvement in implementation of guidelines and effective blood-sparing interventions. Many patients presenting for surgery receive antiplatelet and/or antifibrinolytic therapy, yet the subsequent benefits and risks remain unclear.
    Materialart: Online-Ressource
    ISSN: 0310-057X , 1448-0271
    URL: Article
    DOI: 10.1177/0310057X0703500516
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2007
    ZDB Id: 2053705-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Detection and quantitation of normal and variant haemoglobins: an analytical review
    SAGE Publications ; 2004
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 41, No. 5 ( 2004-09-01), p. 355-369
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 41, No. 5 ( 2004-09-01), p. 355-369
    Kurzfassung: As well as six 'normal' haemoglobins that occur at various stages of development, more than 800 abnormal or variant haemoglobins have been described. Many of these variant haemoglobins have no significant clinical consequences apart from causing confusion to clinicians and in laboratories; however, some of the variant haemoglobins result in major morbidity or mortality. The laboratory challenge is to detect these clinically significant haemoglobins and to identify them with sufficient accuracy for clinical purposes, as well as to quantitate both these and the 'normal' haemoglobins. The techniques used to detect and quantitate these haemoglobins in routine service laboratories are discussed in detail. Methods used by referral laboratories, such as mass spectrometry and DNA analysis, are briefly discussed. Haemoglobin analysis is most often undertaken as part of neonatal, antenatal or pre-anaesthetic screening; these programmes are reviewed, together with possible changes to neonatal screening and antenatal screening that may occur as part of the NHS National Plan.
    Materialart: Online-Ressource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1258/0004563041731600
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2004
    ZDB Id: 2041298-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Acute changes in Atherogenic and Thrombogenic Factors with Cessation of Smoking
    SAGE Publications ; 1990
    In:  Journal of the Royal Society of Medicine Vol. 83, No. 3 ( 1990-03), p. 146-148
    Details
    In: Journal of the Royal Society of Medicine, SAGE Publications, Vol. 83, No. 3 ( 1990-03), p. 146-148
    Kurzfassung: Tobacco smoking is associated with alterations in several factors considered to be important in the atherosclerotic process. Thirty chronic smokers were studied 2 weeks before and 2 weeks after complete tobacco withdrawal. Significant reductions in fibrinogen, haematocrit, plasma viscosity and whole blood viscosity as well as a significant increase in HDL-cholesterol were observed. As these factors are important in both atherogenesis and thrombogenesis, these observations may give insight into tobacco-induced atherosclerotic disease and may be responsible for the more rapid reduction in the incidence of cardiovascular disease that is believed to occur after stopped smoking.
    Materialart: Online-Ressource
    ISSN: 0141-0768 , 1758-1095
    URL: Article
    DOI: 10.1177/014107689008300306
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1990
    ZDB Id: 2046643-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Familial Polymyalgia Rheumatica
    SAGE Publications ; 1981
    In:  Scottish Medical Journal Vol. 26, No. 1 ( 1981-01), p. 59-61
    Details
    In: Scottish Medical Journal, SAGE Publications, Vol. 26, No. 1 ( 1981-01), p. 59-61
    Kurzfassung: We report the cases of two sisters of a Scottish family who developed polymyalgia rheumatica at the age of 14 and 72 years respectively. Previous reports of familial polymyalgia rheumatica and giant-cell arteritis have been infrequent, and the patients were of other racial groups. The relevance of these observations with regard to the genetic factor in the causation of polymyalgia rheumatica is discussed.
    Materialart: Online-Ressource
    ISSN: 0036-9330 , 2045-6441
    URL: Article
    DOI: 10.1177/003693308102600114
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1981
    ZDB Id: 2141765-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    South Africa's Economic Transformation since 1994: What Influence has the National Democratic Revolution (NDR) Had?
    SAGE Publications ; 2017
    In:  The Review of Black Political Economy Vol. 44, No. 3-4 ( 2017-01), p. 327-340
    Details
    In: The Review of Black Political Economy, SAGE Publications, Vol. 44, No. 3-4 ( 2017-01), p. 327-340
    Kurzfassung: When the African National Congress (ANC) became the democratic government of South Africa in 1994, it faced the challenge of transforming the economy. How this was to be done, however, revolved around two divergent views of the National Democratic Revolution (NDR) which forms the underlying ideology or glue that binds together the Tripartite Alliance comprising the ANC, the South African Communist Party (SACP) and the Congress of South African Trade Unions (COSATU), the largest workers’ union in the country. Transformation could be achieved either radically through measures such as nationalisation where political control would be transposed into economic power, or via a more liberal route involving the promotion of macro-economic development and the growth of company earnings. This article investigates how the ANC government has sought to bring about the much-needed transformation by providing summary analyses of the following macro-economic policies: the Reconstruction and Development Programme (RDP), the Growth, Employment and Redistribution (GEAR) strategy, the Accelerated and Shared Growth Initiative - South Africa (ASGISA), the New Growth Path (NGP) and the National Development Plan (NDP). Evidence suggests that while the NDR promised radical results, the economic transformation that has been taking place in South Africa since 1994 has been driven largely by neo-liberal principles. This is in contrast to what the ANC claims in various policy documents and what various scholars, such as Jeffery (2010:5) and Venter (2012), have also claimed. As South Africa's economic fortunes have declined in recent years in the face of mounting external pressures and internal policy uncertainty, this deviation from the original ideology and plan is causing significant discord in the country.
    Materialart: Online-Ressource
    ISSN: 0034-6446 , 1936-4814
    URL: Article
    DOI: 10.1007/s12114-017-9260-2
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2024107-0
    SSG: 6,31
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    A pragmatic, multi-centered, stepped wedge, cluster randomized controlled trial pilot of the clinical and cost effectiveness of a complex Stroke Oral healthCare intervention pLan Evaluation II (SOCLE II) compared with usual oral healthcare in stroke wards
    SAGE Publications ; 2020
    In:  International Journal of Stroke Vol. 15, No. 3 ( 2020-04), p. 318-323
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 15, No. 3 ( 2020-04), p. 318-323
    Kurzfassung: Patients with stroke-associated pneumonia experience poorer outcomes (increased hospital stays, costs, discharge dependency, and risk of death). High-quality, organized oral healthcare may reduce the incidence of stroke-associated pneumonia and improve oral health and quality of life. Aims We piloted a pragmatic, stepped-wedge, cluster randomized controlled trial of clinical and cost effectiveness of enhanced versus usual oral healthcare for people in stroke rehabilitation settings. Methods Scottish stroke rehabilitation wards were randomly allocated to stepped time-points for conversion from usual to enhanced oral healthcare. All admissions and nursing staff were eligible for inclusion. We piloted the viability of randomization, intervention, data collection, record linkage procedures, our sample size, screening, and recruitment estimates. The stepped-wedge trial design prevented full blinding of outcome assessors and staff. Predetermined criteria for progression included the validity of enhanced oral healthcare intervention (training, oral healthcare protocol, assessment, equipment), data collection, and stroke-associated pneumonia event rate and relationship between stroke-associated pneumonia and plaque. Results We screened 1548/2613 (59%) admissions to four wards, recruiting n = 325 patients and n = 112 nurses. We observed marked between-site diversity in admissions, recruitment populations, stroke-associated pneumonia events (0% to 21%), training, and resource use. No adverse events were reported. Oral healthcare documentation was poor. We found no evidence of a difference in stroke-associated pneumonia between enhanced versus usual oral healthcare ( P = 0.62, odds ratio = 0.61, confidence interval: 0.08 to 4.42). Conclusions Our stepped-wedge cluster randomized control trial accommodated between-site diversity. The stroke-associated pneumonia event rate did not meet our predetermined progression criteria. We did not meet our predefined progression criteria including the SAP event rate and consequently were unable to establish whether there is a relationship between SAP and plaque. A wide confidence interval did not exclude the possibility that enhanced oral healthcare may result in a benefit or detrimental effect. Trial Registration NCT01954212.
    Materialart: Online-Ressource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493019871824
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2211666-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Rejoinder
    SAGE Publications ; 2017
    In:  Clinical Trials Vol. 14, No. 2 ( 2017-04), p. 126-127
    Details
    In: Clinical Trials, SAGE Publications, Vol. 14, No. 2 ( 2017-04), p. 126-127
    Materialart: Online-Ressource
    ISSN: 1740-7745 , 1740-7753
    URL: Article
    DOI: 10.1177/1740774516688917
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2159773-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Conservatives Are More Reluctant to Give and Receive Apologies Than Liberals
    SAGE Publications ; 2017
    In:  Social Psychological and Personality Science Vol. 8, No. 7 ( 2017-09), p. 827-835
    Details
    In: Social Psychological and Personality Science, SAGE Publications, Vol. 8, No. 7 ( 2017-09), p. 827-835
    Kurzfassung: This article examines the proposition that conservatives will be less willing than liberals to apologize and less likely to forgive after receiving an apology. In Study 1, we found evidence for both relationships in a nine-nation survey. In Study 2, participants wrote an open-ended response to a victim of a hypothetical transgression they had committed. More conservative participants were less likely to include apologetic elements in their response. We also tested two underlying mechanisms for the associations: social dominance orientation (SDO) and entity beliefs about human nature. SDO emerged as a stronger and more consistent mediator than entity beliefs. Apologies are theorized to be a rhetorical vehicle for removing power inequities in relationships posttransgression. Consistent with this theorizing, it was those who are relatively high in commitment to equality (i.e., those high in liberal ideology and low in SDO) who are most likely to provide and reward apologies.
    Materialart: Online-Ressource
    ISSN: 1948-5506 , 1948-5514
    URL: Article
    DOI: 10.1177/1948550617691096
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2017
    ZDB Id: 2532395-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Gastric Infarction in Cynomolgus Monkeys ( Macaca fascicularis )
    SAGE Publications ; 1996
    In:  Veterinary Pathology Vol. 33, No. 2 ( 1996-03), p. 171-175
    Details
    In: Veterinary Pathology, SAGE Publications, Vol. 33, No. 2 ( 1996-03), p. 171-175
    Kurzfassung: Five cases of gastric infarction were observed in adolescent or adult cynomolgus monkeys ( Macaca fascicularis) over a 20-month period. Gastric infarcts were encountered as striking and unexpected findings at necropsy. Gross and microscopic findings included gastric necrosis, hemorrhage, and edema that involved large areas of the fundus and pylorus. A consistent finding was the presence of thrombi in the gastric microvasculature, particularly in the venous system. All animals had acute clinical episodes with substantial tissue damage resulting from a variety of causes, including trauma, pancreatitis, necrotizing cystitis, and intestinal intussusception. In addition, three animals had microvascular thrombosis in nongastric tissues. Our findings suggest that cynomolgus monkeys may be predisposed to developing gastric infarction under conditions of severe systemic insult that predispose to disseminated intravascular coagulation.
    Materialart: Online-Ressource
    ISSN: 0300-9858 , 1544-2217
    URL: Article
    DOI: 10.1177/030098589603300206
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 1996
    ZDB Id: 2106608-5
    SSG: 22
    Standort Signatur Einschränkungen Verfügbarkeit
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