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  • SAGE Publications  (23)
  • 1
    Online-Ressource
    Online-Ressource
    Impact on Survival of Timing and Duration of Adjuvant Chemotherapy in Radically Resected Gastric Cancer
    SAGE Publications ; 2016
    In:  Tumori Journal Vol. 102, No. 4 ( 2016-07), p. e15-e19
    Details
    In: Tumori Journal, SAGE Publications, Vol. 102, No. 4 ( 2016-07), p. e15-e19
    Kurzfassung: Adjuvant chemotherapy improves survival of patients with gastric cancer. Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach (ITACA-S) was a phase III study comparing sequential FOLFIRI followed by docetaxel/cisplatin versus 5-fluorouracil monotherapy. The intensive regimen was not superior in terms of disease-free survival (DFS) and overall survival (OS). Methods The treatment was to be started within 8 weeks from surgery. This analysis evaluates the impact of time from surgery to chemotherapy start (TSC) on outcomes. Results Out of 1,106 randomized, 1,072 patients without major violations of eligibility criteria and receiving at least one treatment cycle were analyzed. Median TSC was 50 days. Chemotherapy was interrupted in 201 (18.8%) cases, whereas it was completed without or with modifications in 277 (25.8%) and 594 (55.4%), respectively. At a median follow-up of 56.9 months, 513 progressions and 472 deaths occurred. A longer TSC was significantly associated with longer DFS (hazard ratio [HR] 0.95; 95% confidence interval [CI] 0.89-1.00; p = 0.05) and OS (HR 0.91; 95% CI 0.86-0.97; p = 0.004), after adjustment for treatment arm, age, sex, primary tumor site, number of resected nodes, and tumor stage. Better treatment compliance was associated with improved survival. Conclusions Our findings suggest that longer TSC had at least no detrimental effect on DFS and OS, whereas treatment completion had a protective effect. Our findings need to be confirmed prospectively.
    Materialart: Online-Ressource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.5301/tj.5000480
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2016
    ZDB Id: 280962-X
    ZDB Id: 2267832-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Phase I Clinical Trial with the AMC-Bioartificial Liver
    SAGE Publications ; 2002
    In:  The International Journal of Artificial Organs Vol. 25, No. 10 ( 2002-10), p. 950-959
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 25, No. 10 ( 2002-10), p. 950-959
    Kurzfassung: Recently a bio-artificial liver (BAL) system has been developed at the Academic Medical Center (AMC) of Amsterdam to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT). After successful testing of the AMC-BAL in rodents and pigs with ALF, a phase I study in ALF patients waiting for (OLT) was started in Italy. We present the safety outcome of the first 7 patients aged 21–56 years with coma grade III or IV. The total AMC-BAL treatment time ranged from 8 to 35 hours. Three patients received 2 treatments with two different BAL's within three days. Six of the 7 patients were successfully bridged to OLT. One patient showed improved liver function after two treatments and did not need OLT. No severe adverse events of the BAL treatment were noted. Conclusion Treatment of ALF patients with the AMC-BAL is a safe and feasible technique to bridge the waiting time for an adequate liver-graft.
    Materialart: Online-Ressource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139880202501009
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2002
    ZDB Id: 1474999-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Antibodies to Carbonic Anhydrase in Patients with Connective Tissue Diseases: Relationship with Lung Involvement
    SAGE Publications ; 2008
    In:  International Journal of Immunopathology and Pharmacology Vol. 21, No. 3 ( 2008-07), p. 659-667
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 21, No. 3 ( 2008-07), p. 659-667
    Kurzfassung: The aim of this study is to evaluate the presence of antibodies to carbonic anhydrase I and/or II (ACAI and ACAII) in patients affected by connective tissue diseases (CTD) and to investigate their association with lung involvement evaluated by High resolution CT scan (HRCT). Ninety-six patients affected by CTD were studied, i.e. 33 rheumatoid arthritis (RA), 8 psoriatic arthritis (PA), 8 ankylosing spondilitis (AS), 23 Systemic Lupus Erythematosus (SLE), 10 Sjogren Syndrome (SS), and 14 Systemic Sclerosis (SSc). ACA were detected by ELISA. The lung involvement was evaluated by means of a previously described HRCT score. According to a receiver operator characteristic curve, patients were divided into those with HRCT score ≥ 10 and those with HRCT score 〈 10, where HRCT score ≥ 10 was predictive of interstitial lung disease. ACAI and/or ACAII were detected in 30/96 patients (31.2%) (P 〈 0.0001 in comparison with controls). In particular, the prevalence of ACAI and/or ACAII was significantly higher in patients with RA (P = 0.002), PA (P 〈 0.0001), SLE (P = 0.0003) and SSc (P 〈 0.0001). A positive correlation was found between HRCT scores and CRP or ACAI levels (P= 〈 0.0001 and P=0.004, respectively). Thirty-nine of 96 patients (40.6%) showed a HRCT score ≥ 10 and both their CRP and ACAI levels were significantly higher when compared with patients showing a HRCT score 〈 10 (P 〈 0.0006 and P = 0.0009, respectively). Moreover, C3 and C4 complement fractions inversely correlated with HRCT scores (P = 0.0004 and P 〈 0.0001, respectively) and lower values of C3 and C4 complement fractions were found in patients with HRCT score ≥ 10 than in those with HRCT score 〈 10 (P = 0.014 and P = 0.007, respectively). Due to the lower levels of complement fractions detected in patients with HRCT score ≥ 10, a possible immune-complex-mediated pathogenic mechanism of lung involvement could be suggested.
    Materialart: Online-Ressource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/039463200802100320
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2008
    ZDB Id: 2505963-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Safety Evaluation of Routine Intracoronary Acetylcholine Infusion in Patients Undergoing a First Diagnostic Coronary Angiogram
    SAGE Publications ; 2002
    In:  Journal of Investigative Medicine Vol. 50, No. 2 ( 2002-03), p. 133-139
    Details
    In: Journal of Investigative Medicine, SAGE Publications, Vol. 50, No. 2 ( 2002-03), p. 133-139
    Kurzfassung: Recent findings imply prognostic significance of intracoronary acetylcholine infusion for endothelial function testing. We evaluated whether routine use of this test in coronary angiography patients is safe. Methods Patients undergoing a first diagnostic coronary angiography were selected to receive intracoronary acetylcholine for endothelial function evaluation. The relation between adverse reactions during infusion and risk factors was analyzed with a logistic regression model. Included in the multiple logistic regression model were the variables with a univariate P value 〈 0.20. Results Adverse reactions occurred in 16% (49/299) of the patients. This included two life-threatening events caused by occlusive spasm and flow limitation in the left coronary artery. Other adverse events were chest pain (n = 38), AV block or sinus bradycardia (n = 10), dyspnea (n = 3). Adverse reactions were more likely to occur in patients younger than 60 years of age (relative risk, 5.6 [2.2–14.3]). Conclusion Intracoronary acetylcholine infusion is safe, but may lead to serious adverse reactions. Care should be taken especially in patients younger than 60 years of age. Routine use of acetylcholine infusion can thus only be justified if it has important prognostic significance. This has to be proven further in large prospective studies.
    Materialart: Online-Ressource
    ISSN: 1081-5589 , 1708-8267
    URL: Article
    DOI: 10.2310/6650.2002.31305
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2002
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Apoptosis and Autoimmunity Induced by Clodronate in Systemic Lupus Erythematosus Mononuclear Circulating Cells
    SAGE Publications ; 2010
    In:  International Journal of Immunopathology and Pharmacology Vol. 23, No. 2 ( 2010-04), p. 535-542
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 23, No. 2 ( 2010-04), p. 535-542
    Kurzfassung: The aim of this study is to evaluate the effect of clodronate on apoptosis of human systemic lupus erythematosus circulating mononuclear cells and to analyze possible correlations with changes in autoantibody production in vitro. Lympho-monocytes from 20 SLE patients were isolated and incubated with or without addition of 1 μM clodronate for 72 hours. Apoptosis and release of genomic material was assessed by immunofluorescent detection of cleaved caspase-3 and by Cell-Death-Detection ELISAPLUS kit (Roche). Anti-Nucleosome IgG and anti-dsDNA IgM and IgG autoantibody levels were determined in supernatants by commercially available ELISA kits. Clodronate induced apoptosis in monocytes as confirmed by cleaved caspase-3 immunostaining and by quantification of cleaved nucleosome in the supernatants (treated 0.22±0.05 O.D. vs untreated 0.09±0.04 O.D.; P 〈 0.001). This finding was coupled with a significant increasing in supernatants of IgG anti-Nucleosome (treated 6.5±1.1 vs untreated 5.5±0.6 IU/mL; p=0.001) and IgM (treated 3.0±1.3 vs 2.2±0.9 IU/mL; p=0.02) and IgG (treated 4.0±1.8 vs untreated 2.8±1.5 IU/mL; p=0.02) anti-dsDNA autoantibody levels. Our findings stressed the proapoptotic activity of clodronate, as well as its potential autoimmunity induction in SLE mononuclear circulating cells. Clinical studies could clarify the role of bisphosphonates on autoantibody production and worsening of disease activity.
    Materialart: Online-Ressource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/039463201002300215
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2010
    ZDB Id: 2505963-4
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Stiffness parameters, intima-media thickness and early atherosclerosis in systemic lupus erythematosus patients
    SAGE Publications ; 2009
    In:  Lupus Vol. 18, No. 3 ( 2009-03), p. 249-256
    Details
    In: Lupus, SAGE Publications, Vol. 18, No. 3 ( 2009-03), p. 249-256
    Kurzfassung: Detection of early carotid vascular disease in patients with systemic lupus erythematosus (SLE) is considered mandatory for evaluation of subclinical atherosclerosis (ATS), and various ultrasonographic (US) parameters have been proposed. In the present investigation, 33 SLE and 33 healthy age-matched females have been studied by colour-coded sonography of the common carotid artery, assessing intima-media thickness (IMT), vascular strain (VS), vascular distensibility (VD), vascular stiffness (VSf) and pressure-strain elastic modulus (PSEM) as possible markers of early ATS. Patients with SLE, despite equivalent exposure to “traditional” cardiovascular risk factors, presented a higher mean IMT of the common carotid artery than healthy subjects (0.7 ± 0.2 mm vs 0.5 ± 0.1 mm – P  〈  0.0001). Of the stiffness parameters, patients with lupus showed a mean VSf of 0.72 ± 0.38 vs 0.54 ± 0.14 in controls ( P  〈  0.0001) and a mean PSEM of 6.0 ± 2.8 Pa vs 3.0 ± 1.4 Pa in controls ( P  〈  0.0001). Mean VS and VD were significantly lower in patients with SLE than in healthy subjects ( P  〈  0.0001). Among individuals with IMT  〈  0.6 mm, patients with SLE presented more compromised stiffness parameters. IMT was shown to be a useful parameter in the evaluation of vascular damage, even in a “sub-clinical” phase, while stiffness parameters provide additional details regarding endothelial and vessel functional state. Combined evaluation may allow ATS to be detected in the early stages in patients with SLE.
    Materialart: Online-Ressource
    ISSN: 0961-2033 , 1477-0962
    URL: Article
    DOI: 10.1177/0961203308097571
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2009
    ZDB Id: 2008035-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Safety and Infectious Prophylaxis of Intravenous Immunoglobulin in Elderly Patients with Membranous Nephropathy
    SAGE Publications ; 2014
    In:  International Journal of Immunopathology and Pharmacology Vol. 27, No. 2 ( 2014-04), p. 305-308
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 27, No. 2 ( 2014-04), p. 305-308
    Kurzfassung: A variety of infections has been recognized as an important cause of morbidity and mortality in patients with nephrotic syndrome, and membranous nephropathy is a common cause of this in the elderly. The reasons for infection risk are due to oedema complications, urinary loss of factor B and D of the alternative complement pathway, cellular immunity, granulocyte chemotaxis, hypogammaglobulinemia with serum IgG levels below 600 mg/dL, and secondary effects of immunosuppressive therapy. Many different prophylactic interventions have been used for reducing the risks of infection in these patients but recommendations for routine use are still lacking. We report two membranous nephropathy cases in the elderly in which Intravenous immunoglobulin were useful in long-term infectious prophylaxis, showing safety in renal function. During immunosuppressant therapy in membranous nephropathy, intravenous immunoglobulin without sucrose are a safe therapeutic option as prophylaxis in those patients with nephrotic syndrome and IgG levels below 600 mg/dL. The long-term goal of infection prevention in these patients is to reduce mortality, prolong survival and improve quality of life.
    Materialart: Online-Ressource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/039463201402700220
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2014
    ZDB Id: 2505963-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    N-Acetylcysteine Infusion Improves Hepatic Perfusion in the Early Stages of Systemic Sclerosis
    SAGE Publications ; 2009
    In:  International Journal of Immunopathology and Pharmacology Vol. 22, No. 3 ( 2009-07), p. 763-772
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 22, No. 3 ( 2009-07), p. 763-772
    Kurzfassung: The aim of our study is to evaluate portal and hepatic hemodynamic changes after N-acetylcysteine infusion in patients with systemic sclerosis. In an open-label study 40 patients with Systemic Sclerosis (SSc) were treated with 15mg/kg/hour intravenous N-acetylcysteine for 5 consecutive hours in a single day. Hepatic flow volume, congestion index, portal flow volume, resistance index and pulse rate index were measured in each subject before and after infusion. In all patients mean hepatic flow volume (HFV) and mean portal flow volume (PFV) values after the five-hour infusion with NAC increased not significantly. In 22 selected patients with active capillaroscopic pattern, modified Rodnan Total Skin Score (mRTSS) 〈 18 and mild-moderate score to vascular domain of disease severity scale (DSS), mean HFV increased significantly when compared with mean HFV of 18 SSc patients with late capillaroscopic pattern, mRTSS 〉 18 and severe-end stage score to vascular domain of DSS. The results of our study demonstrate that NAC is able to increase HFV and total liver perfusion after a single infusion in SSc patients with low disease activity and severity scores.
    Materialart: Online-Ressource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/039463200902200322
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2009
    ZDB Id: 2505963-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Clinical and Histological Outcome Predictors in Renal Limited Pauci-Immune Crescentic Glomerulonephritis: A Single Centre Experience
    SAGE Publications ; 2012
    In:  International Journal of Immunopathology and Pharmacology Vol. 25, No. 1 ( 2012-01), p. 287-292
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 25, No. 1 ( 2012-01), p. 287-292
    Kurzfassung: Renal-limited vasculitis is a pauci-immune crescentic glomerulonephritis with no signs of systemic involvement, representing one of the most common causes of rapidly progressive glomerulonephritis. The study aims to examine clinical and histological features in twenty-four patients with RLV diagnosed by the Nephrology Department of Sapienza University of Rome, Italy, evaluating the role of these parameters in predicting renal survival. Patients details, clinical and histological features and outcomes were recorded at the time of renal biopsy and over a mean follow-up period of 36±6 months. In our study, serum creatinine at presentation was significantly higher in patients who had a poor outcome than in those who survived with independent renal function (6.3±2.47 mg/dl vs 2.84±2.01 mg/dl, P= 0.002). The presence of C3c was found in the area of glomerular fibrinoid necrosis and in small arteries and arterioles with fibrinoid necrosis in 17 patients (P= 0.018). In conclusion, serum creatinine at presentation and focal C3c depositions in areas of glomerular and arteriolar fibrinoid necrosis were the best determinants of poor renal outcome, maybe underlining the pathogenic role of alternative pathway activation of complement system but also demonstrating the focal distribution of necrotizing lesions.
    Materialart: Online-Ressource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/039463201202500133
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2012
    ZDB Id: 2505963-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium
    SAGE Publications ; 2019
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 25 ( 2019-01-01), p. 107602961985303-
    Details
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 25 ( 2019-01-01), p. 107602961985303-
    Kurzfassung: Pulmonary embolism (PE) is a life-threatening condition and a leading cause of morbidity and mortality. There have been many advances in the field of PE in the last few years, requiring a careful assessment of their impact on patient care. However, variations in recommendations by different clinical guidelines, as well as lack of robust clinical trials, make clinical decisions challenging. The Pulmonary Embolism Response Team Consortium is an international association created to advance the diagnosis, treatment, and outcomes of patients with PE. In this consensus practice document, we provide a comprehensive review of the diagnosis, treatment, and follow-up of acute PE, including both clinical data and consensus opinion to provide guidance for clinicians caring for these patients.
    Materialart: Online-Ressource
    ISSN: 1076-0296 , 1938-2723
    URL: Article
    DOI: 10.1177/1076029619853037
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2019
    ZDB Id: 2230591-9
    Standort Signatur Einschränkungen Verfügbarkeit
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