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  • 1
    In: Journal of Pharmacy Practice, SAGE Publications, Vol. 30, No. 2 ( 2017-04), p. 172-179
    Abstract: To compare between weekly and daily cholecalciferol in patients with hypovitaminosis D and to determine the optimal maintenance dose. Methods: Seventy-one volunteers with hypovitaminosis D were randomly assigned to 2 dose regimens: cholecalciferol 50 000 IU weekly for 8 weeks, then 50 000 IU monthly for 2 months (group A) and 7000 IU daily for 8 weeks, then 12 500 IU weekly for 2 months (group B). Cholecalciferol was stopped for 2 months and reintroduced as 50 000 IU bimonthly for group A and 50 000 IU monthly for group B. Results: Two months after therapy, the mean serum 25-hydroxyvitamin D (25(OH)D) level increased from 11.4 to 51.2 ng/mL and from 11.7 to 44.9 ng/mL in groups A and B, respectively ( P = .065). The levels of 25(OH)D declined similarly in both groups during maintenance and after holding therapy. After resuming cholecalciferol, 25(OH)D levels increased to 33.8 and 28.8 ng/mL in groups A and B, respectively ( P = .027). There was a negative correlation between serum 25(OH)D levels and body mass index (BMI; P = .040). Conclusion: Timing and frequency of the dosing (daily vs weekly) have no effect on the rise in serum 25(OH)D levels as long as the accumulative dose of cholecalciferol is similar. Cholecalciferol 50 000 IU bimonthly is required to maintain sufficient 25(OH)D levels.
    Type of Medium: Online Resource
    ISSN: 0897-1900 , 1531-1937
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2131091-9
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2013
    In:  The British Journal of Diabetes & Vascular Disease Vol. 13, No. 1 ( 2013-01), p. 37-42
    In: The British Journal of Diabetes & Vascular Disease, SAGE Publications, Vol. 13, No. 1 ( 2013-01), p. 37-42
    Abstract: This study aims to screen patients with type 2 diabetes mellitus for peripheral arterial disease (PAD) and to determine the agreement between ankle brachial index (ABI) and toe brachial index (TBI). A total of 182 diabetic patients at 40 years of age or older were assessed using both ABI and TBI. Mean age was 60.5 (SD ±8.1) years. PAD was present in 28.9% and 5.4% of patients according to TBI and ABI definitions respectively. The prevalence of high ABI (ABI 〉 1.3) was 16.5%. The agreement between TBI and ABI results was fair. Current smoking was associated with low ABI whereas age was inversely associated with TBI. We strongly suggest using both the ABI and TBI as screening tests for PAD because the agreement between these tests was fair, they complement each other in most instances and they detect PAD at different anatomical levels.
    Type of Medium: Online Resource
    ISSN: 1474-6514 , 1753-4305
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2429646-6
    detail.hit.zdb_id: 3018522-1
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  SAGE Open Medicine Vol. 7 ( 2019-01), p. 205031211987615-
    In: SAGE Open Medicine, SAGE Publications, Vol. 7 ( 2019-01), p. 205031211987615-
    Abstract: In Jordan, many studies reported various rates of vitamin D deficiency and insufficiency among different groups. This study aimed to determine the prevalence of low vitamin D level among Jordanian adults and determine its association with selected variables. Methods: The vitamin D level was assessed in a national representative sample of 4056 subjects aged 〉 17 years. The study involved face-to-face interviews with the subjects and measurement of serum 25(OH)D. Low vitamin D level was defined as 25(OH)D  〈  30 ng/mL. Deficiency was defined as 25(OH)D  〈  20 ng/mL, and insufficiency was defined as 25(OH)D level of 20–30 ng/mL. Results: The overall prevalence of low vitamin D status (25(OH)D  〈  30 ng/mL) was 89.7%, with higher prevalence in males (92.4%) than in females (88.6%). Vitamin D was sufficient in 7.6% of males, insufficient in 38.4% of males, and deficient in 54% of males. Among females, vitamin D was insufficient in 10.1% and deficient in 78.5%. The prevalence of vitamin D deficiency was much higher in females than in males ( p = 0.001). The only variables that were significantly associated with low level of vitamin D were gender, age, obesity, and employment. Conclusion: The prevalence of low vitamin D level is extremely high in Jordan. Age, gender, obesity, and unemployment were associated with low levels of vitamin D. Health authorities in Jordan need to increase the level of awareness about vitamin D deficiency and its prevention, particularly among women.
    Type of Medium: Online Resource
    ISSN: 2050-3121 , 2050-3121
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2735399-0
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