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  • 1
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    Online Resource
    Conflict Warnings and the Search and Detection of Collisions in a Simulated Atc-Like Task
    SAGE Publications ; 2001
    In:  Proceedings of the Human Factors and Ergonomics Society Annual Meeting Vol. 45, No. 4 ( 2001-10), p. 458-462
    Details
    In: Proceedings of the Human Factors and Ergonomics Society Annual Meeting, SAGE Publications, Vol. 45, No. 4 ( 2001-10), p. 458-462
    Abstract: An experiment assessed the effects of properties of a warning system on visual search patterns and collision detection efficiency in a simulated air traffic control-like task. Participants had to detect collisions between pairs of objects before they occurred. They were assisted by warning systems that had different levels of reliability and gave a warning either 5 or 15 seconds prior to a collision. The participants' eye-movements were recorded. The detection of the collisions was not affected by the timing of the warning, but only by the reliability of the warning system. However, visual search patterns differed markedly between early and late warnings. A metric was developed to calculate an “attention value” out of the eye-movement data. The metric corresponds well to the behavior of the participants in the different experimental conditions. This may be particularly important for the analysis of real air traffic control tasks.
    Type of Medium: Online Resource
    ISSN: 2169-5067 , 1071-1813
    URL: Article
    DOI: 10.1177/154193120104500441
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2415770-3
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  • 2
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    “Microflex”—A New Assembling Technique for Interconnects
    SAGE Publications ; 2000
    In:  Journal of Intelligent Material Systems and Structures Vol. 11, No. 6 ( 2000-06), p. 417-425
    Details
    In: Journal of Intelligent Material Systems and Structures, SAGE Publications, Vol. 11, No. 6 ( 2000-06), p. 417-425
    Abstract: A new interconnection technique has been developed that allows versatile multiple strand connections between microsensors, sensor arrays, and chips designed for wire bonding. The new technique has been termed “Microflex interconnection” technique (MFI). Conventional wire bonding technique is commonly restricted to planar interconnects with a limited degree of freedom for placing microsystem components in hybrid assemblies. The MFI technique has overcome this limitation by interconnecting microsystem components through custom designed flexible substrates with embedded metallized conductors, pad arrays for integrated circuits’ assembly and substrate integrated electrodes. Standard CMOS components without additional pad metallization can be used. The integration density of the MFI technique corresponds to one of the flip-chip technology. Special advantages of the MFI technique are three-dimensional interconnects, the flexibility in design and shape, and easy visual inspection of alignment qualities. The method is especially suitable for small volumes of customer specified devices and biomedical implants because all materials used are biocompatible. Within this paper, the MFI technique is introduced, described in detail, and tested according to international standards. The evaluation of the electrical and mechanical properties of the interconnection sites exhibited promising results regarding stability and reliability. First applications in the biomedical field were presented on the example of a neural implant and a sensorized cardiac catheter.
    Type of Medium: Online Resource
    ISSN: 1045-389X , 1530-8138
    URL: Article
    DOI: 10.1106/R7BV-511B-21RJ-R2FA
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2088313-4
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  • 3
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    Online Resource
    "Microflex" - A New Assembling Technique for Interconnects
    SAGE Publications ; 2000
    In:  Journal of Intelligent Materials Systems and Structures Vol. 11, No. 6 ( 2000-06-01), p. 417-425
    Details
    In: Journal of Intelligent Materials Systems and Structures, SAGE Publications, Vol. 11, No. 6 ( 2000-06-01), p. 417-425
    Type of Medium: Online Resource
    ISSN: 1045-389X , 0000-0000
    URL: Article
    DOI: 10.1177/104538900772664585
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2088313-4
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  • 4
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    Diffusion MRI: A New Strategy for Assessment of Cancer Therapeutic Efficacy
    SAGE Publications ; 2002
    In:  Molecular Imaging Vol. 1, No. 4 ( 2002-10-1), p. 336-343
    Details
    In: Molecular Imaging, SAGE Publications, Vol. 1, No. 4 ( 2002-10-1), p. 336-343
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1535-3508
    URL: Article
    DOI: 10.1162/153535002321093945
    Language: Unknown
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2069848-3
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  • 5
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    Diffusion MRI: A New Strategy for Assessment of Cancer Therapeutic Efficacy
    SAGE Publications ; 2002
    In:  Molecular Imaging Vol. 1, No. 4 ( 2002-10-01), p. 153535002002214-
    Details
    In: Molecular Imaging, SAGE Publications, Vol. 1, No. 4 ( 2002-10-01), p. 153535002002214-
    Abstract: The use of anatomical imaging in clinical oncology practice traditionally relies on comparison of patient scans acquired before and following completion of therapeutic intervention. Therapeutic success is typically determined from inspection of gross anatomical images to assess changes in tumor size. Imaging could provide significant additional insight into therapeutic impact if a specific parameter or combination of parameters could be identified which reflect tissue changes at the cellular or physiologic level. This would provide an early indicator of treatment response/outcome in an individual patient before completion of therapy. Moreover, response of a tumor to therapeutic intervention may be heterogeneous. The use of imaging could assist in delineating therapeutic-induced spatial heterogeneity within a tumor mass by providing information related to specific regions that are resistant or responsive to treatment. Largely untapped potential resides in exploratory methods such as diffusion MRI, which is a non-volumetric intravoxel measure of tumor response based upon water molecular mobility. Alterations in water mobility reflect changes in tissue structure at the cellular level. While the clinical utility of diffusion MRI for oncologic practice is still under active investigation, this overview on the use of diffusion MRI for the evaluation of brain tumors will serve to introduce how this approach may be applied in the future for the management of patients with solid tumors.
    Type of Medium: Online Resource
    ISSN: 1536-0121 , 1536-0121
    URL: Article
    DOI: 10.1162/15353500200221482
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2069848-3
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  • 6
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    Endoscopic Transnasal Pituitary Surgery: Report on 180 Cases
    SAGE Publications ; 2001
    In:  American Journal of Rhinology Vol. 15, No. 4 ( 2001-07), p. 281-287
    Details
    In: American Journal of Rhinology, SAGE Publications, Vol. 15, No. 4 ( 2001-07), p. 281-287
    Abstract: The endoscopic transnasal approach is an evolving technique for treating lesions in the sella turcica. Since this method was introduced at our institution 4 years ago, the majority of transsphenoidal procedures are performed with it. The records of all patients having endoscopic transnasal hypophysectomy at the Mayo Clinic during the last 4 years were reviewed retrospectively. The criteria analyzed were safety, functional and cosmetic outcome, and complications. During the 4-year period, the operative procedure was modified to improve operative exposure and safety. The results of our review showed a significant decrease in length of hospital stay, reduced operative time, reduced need for nasal packing, and elimination of a sublabial incision. The complication rate was equivalent to that reported for the traditional transseptal transsphenoidal approach. As the neurosurgeons at our institution gained experience with this approach, an increasing number of pituitary microadenomas were resected safely and successfully. In addition, because of the limited septal dissection, this approach is particularly helpful for revision operations. This approach also can be used for the full range of pituitary lesions and in conjunction with adjunctive techniques, including frontal craniotomy and -knife irradiation. Currently, the endoscopic transsphenoidal approach is the method preferred for surgically treating pituitary lesions in adults at our institution.
    Type of Medium: Online Resource
    ISSN: 1050-6586 , 1539-6290
    URL: Article
    DOI: 10.1177/194589240101500411
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2083922-4
    detail.hit.zdb_id: 2554548-6
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  • 7
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    Emergency Stent-Graft Repair of a Ruptured Hepatic Artery Secondary to Local Postoperative Peritonitis
    SAGE Publications ; 2000
    In:  Journal of Endovascular Therapy Vol. 7, No. 4 ( 2000-08), p. 324-327
    Details
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 7, No. 4 ( 2000-08), p. 324-327
    Abstract: To describe the use of a stent-graft for emergent repair of life-threatening hepatic artery hemorrhage. Methods and Results: A 57-year-old man with a 17-year history of myxoid liposarcoma underwent surgery for a recurrent abdominal mass. Multivisceral resection including a Kausch-Whipple procedure with an extended right hemicolectomy was performed. Three weeks later, an episode of gastrointestinal bleeding prompted surgical repair of the hepatic artery, which had been eroded by infection due to a leaking bilioenteric anastomosis. After 3 weeks of programmed abdominal lavage, bleeding recurred. Angiography documented another rupture of the proximal hepatic artery. After an unsuccessful attempt at coil embolization, a Hemobahn stent-graft was implanted percutaneously during simultaneous cardiopulmonary resuscitation. Hemostasis was secured, and the patient recovered. Over the 10-month follow-up, no bleeding or infection has been observed at the site of the repair, and flow through the hepatic artery endograft remains satisfactory. Conclusions: Percutaneous stent-graft placement can be employed for emergent treatment of visceral artery rupture in patients at high risk for conventional surgical repair.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    URL: Article
    DOI: 10.1177/152660280000700412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2049858-5
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  • 8
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    Sequential Coil Embolization of Bilateral Internal Iliac Artery Aneurysms Prior to Endovascular Abdominal Aortic Aneurysm Repair
    SAGE Publications ; 2001
    In:  Journal of Endovascular Therapy Vol. 8, No. 1 ( 2001-02), p. 87-92
    Details
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 8, No. 1 ( 2001-02), p. 87-92
    Abstract: To report the endovascular repair of concomitant aneurysms of the abdominal aorta and both internal iliac arteries. Case Report: A 72-year-old man with a 5.5-cm abdominal aortic aneurysm (AAA) extending to the right common iliac artery also presented with separate aneurysms of both internal iliac arteries. The patient refused conventional surgery, so an endovascular strategy was devised. Initially, the iliac aneurysms were sequentially coil embolized, allowing several weeks to elapse between the embolization sessions to encourage collateral development. A bifurcated Talent endograft was inserted successfully 8 months after the initial intervention; no evidence of endoleaks or mesenteric ischemia has been seen over a 1-year follow-up. Conclusions: This case illustrates the feasibility of inducing collateralization prior to endovascular AAA repair that would jeopardize internal iliac artery circulation bilaterally. Sequential embolization of the internal iliac arteries over several months initiates this response, paving the way for eventual endovascular repair of the primary aortic aneurysm.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    URL: Article
    DOI: 10.1177/152660280100800115
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2049858-5
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  • 9
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    The Morphology of Islets within the Porcine Donor Pancreas Determines the Isolation Result: Successful Isolation of Pancreatic Islets can Now be Achieved from Young Market Pigs
    SAGE Publications ; 2002
    In:  Cell Transplantation Vol. 11, No. 8 ( 2002-11), p. 827-838
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 11, No. 8 ( 2002-11), p. 827-838
    Abstract: Clinical islet allotransplantation has become an increasingly efficient “routine ” therapy in recent years. Shortage of human donor organs leads to porcine pancreatic islets as a potential source for islet xenotransplantation. Yet it is still very difficult to isolate sufficient numbers of intact porcine islets, particularly from young market pigs. In the following study islets were successfully isolated from retired breeders [4806 ± 720 islet equivalents per gram organ (IEQ/g); n = 25; 2–3 years old; RB] and also from young hybrid pigs [2868 ± 260 IEQ/g; n = 65; 4–6 months old; HY] using LiberasePI and a modified version of Ricordi's digestion-filtration technique. As expected, isolations from RB showed significantly better results (p 〈 0.002). A retrospective histological analysis of almost all donor pancreases showed that the majority of organs from RB (80%) contained mainly large islets (diameter 〉 200 μm), in contrast to only 35% of all pancreases from HY. Remarkably, the islet size in situ, regardless whether detected in RB or HY, strongly determined the isolation result. A donor organ with predominantly large islets resulted in significantly higher numbers of IEQs compared with a donor organ with predominantly small islets [RB Large Islets : 5680 ± 3,318 IEQ/g n = 20); RB Small Islets : 1353 ± 427 IEQ/g (n = 5); p 〈 0.02]. In addition, isolation results were strongly influenced by the quality of the LiberasePI batch, and therefore single batch testing is invariably required. Purification was performed using Ficoll or OptiPrep™ density gradient centrifugation manually or in the COBE cell processor. Although islet purity was highest when OptiPrep™ was used, final islet yields did not differ between the different purification methods. Our study demonstrates that islet size in situ is an extremely critical parameter for highly successful islet isolation; consequently, we are now performing a morphological screening of each donor organ prior to the isolation process. Under these conditions highly successful isolations can reliably be performed even from young market pigs.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/000000002783985323
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2002
    detail.hit.zdb_id: 2020466-8
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  • 10
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    Neural Xenotransplantation: Pretreatment of Porcine Embryonic Nigral Tissue with Anti-Gal Antibodies and Complement is not Toxic for the Dopaminergic Neurons
    SAGE Publications ; 2001
    In:  Cell Transplantation Vol. 10, No. 1 ( 2001-01), p. 25-30
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 10, No. 1 ( 2001-01), p. 25-30
    Abstract: The immunogenicity of porcine tissue is a major obstacle to its use as donor material in xenotransplantation for neurodegenerative diseases. We are currently evaluating a novel strategy for reducing the immunogenicity, in which the α-galactosyl epitope (Galα1,3Galß1,4GlcNAc-R) is used as a target for antibody- and complement-mediated removal of microglia. In the present study, our aim was to determine whether a pretreatment with antibodies against the α-galactosyl epitope (anti-Gal) and complement would lyse or other-wise damage dopaminergic neurons in porcine embryonic ventral mesencephalon (VM), the donor tissue for treatment of Parkinson's disease by xenotransplantation. Cell suspensions prepared from VM tissue from 27-day-old pig embryos were incubated with anti-Gal, purified from normal human serum by affinity chromatography, or medium only (control), and subsequently with rabbit complement. After these pretreatments, the cell suspensions were transplanted into the right striatum of 14 adult rats (two groups of 7 animals). The animals were sacrificed 20 days after transplantation, the brains were processed for histology, and the sections were stained for Nissl substance, porcine neurofilament, tyrosine hydroxylase, and rat CD45 to determine graft volume, presence of porcine neurons, content of dopaminergic cells, and leukocyte infiltration, respectively. The VM tissue pretreated with anti-Gal and complement gave rise to dopaminergic grafts that were indistinguishable from those derived from VM tissue given the control pretreatment. In 5 of the 14 animals, the grafts were infiltrated by host leukocytes, but in two of these recipients, the infiltration was only minimal. We conclude that anti-Gal and complement can be applied to porcine embryonic VM tissue without damaging the dopaminergic neurons and their precursors.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.3727/000000001783986954
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2020466-8
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