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  • S. Karger AG  (12)
  • 1
    Online-Ressource
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    Prognostic Advantage of Docetaxel/Cisplatin/ 5-Fluorouracil Neoadjuvant Chemotherapy in Clinical Stage II/III Esophageal Squamous Cell Carcinoma due to Excellent Control of Preoperative Disease and Postoperative Lymph Node Recurrence
    S. Karger AG ; 2017
    In:  Oncology Vol. 92, No. 4 ( 2017), p. 221-228
    Details
    In: Oncology, S. Karger AG, Vol. 92, No. 4 ( 2017), p. 221-228
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. 〈 b 〉 〈 i 〉 Patients and Methods: 〈 /i 〉 〈 /b 〉 NAC prior to curative treatment was done in 115 cStage II/III ESCC patients with either cisplatin (CDDP)/5-fluorouracil (5-FU; CF) ( 〈 i 〉 n 〈 /i 〉 = 41) or docetaxel/CDDP/5-FU (DCF) NAC ( 〈 i 〉 n 〈 /i 〉 = 74) between 2007 and 2013. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 (1) Esophagectomy was finally performed in 35 of the 41 CF NAC cases and in 48 of the 74 DCF NAC cases. The preservation rate of the esophagus was higher in the DCF NAC than in the CF NAC ( 〈 i 〉 p 〈 /i 〉 = 0.018). (2) The overall survival was better in DCF NAC than in CF NAC ( 〈 i 〉 p 〈 /i 〉 = 0.071), and progression-free survivals were 58.3% with DCF and 30.5% with CF ( 〈 i 〉 p 〈 /i 〉 = 0.0060). DCF NAC was associated with fewer cases of progression than CF NAC ( 〈 i 〉 p 〈 /i 〉 = 0.0040), largely due to excellent control of the preoperative disease ( 〈 i 〉 p 〈 /i 〉 = 0.018) and postoperative lymph node recurrence ( 〈 i 〉 p 〈 /i 〉 = 0.014). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 DCF NAC in cStage II/III ESCC could have a great potential to achieve a better prognosis due to suppression of specific progression events with a higher preservation rate of the esophagus.
    Materialart: Online-Ressource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000455128
    RVK:
    XH 3305
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2017
    ZDB Id: 1483096-6
    ZDB Id: 250101-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Impact of Mental Health Background and Nutrition Intake on Medium-Term Weight Loss in Japanese Patients Undergoing Laparoscopic Sleeve Gastrectomy
    S. Karger AG ; 2020
    In:  Obesity Facts Vol. 13, No. 4 ( 2020), p. 371-383
    Details
    In: Obesity Facts, S. Karger AG, Vol. 13, No. 4 ( 2020), p. 371-383
    Kurzfassung: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Bariatric surgery is the most effective weight loss therapy, and recently laparoscopic sleeve gastrectomy (LSG) is gaining popularity worldwide. On the other hand, patients undergoing bariatric surgery have a high prevalence of mental disorders. A Japanese nationwide survey reported high prevalence of mental disorders in patients with low percent total weight loss (%TWL) and also in those with high %TWL. The aim of this study was to investigate the relationship of 1-year %TWL with background mental health status, 3-year outcomes, and nutrition intake in Japanese patients after LSG. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This study was a single-center retrospective database analysis. A total of 89 Japanese patients who underwent LSG and were followed for 3 years were enrolled (mean age 41.9 years, baseline body mass index 44.9, baseline glycosylated hemoglobin, HbA 〈 sub 〉 1c 〈 /sub 〉 , 7.0%). The patients were divided into 3 groups according to 1-year %TWL as follows: ≤19.9% (insufficient group), 20.0–34.9% (average group) and ≥35.0% (excessive group). Psychosocial and nutritional status as well as physical data were collected from all patients. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The prevalence of mental disorders was 51.7%, and 1-year %TWL was 28.1% in all patients. No significant differences were observed in the changes in body weight and HbA 〈 sub 〉 1c 〈 /sub 〉 between patients with and those without mental disorders. The prevalence of mental disorders was particularly high in the insufficient and excessive groups. In the insufficient group, mood disorders and mental retardation/developmental disorders were frequent, and snacking and eating out habits were often observed. In the excessive group, the frequencies of mood disorders and binge eating were high, and a decrease in skeletal muscle mass due to low protein intake was observed. Furthermore, weight regain was shown 12 months after LSG in both groups. In the average group, there were fewer problems in weight loss outcomes, mental health, nutrition intake and body composition. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Psychosocial and nutritional problems were often found not only in patients with insufficient weight loss, but also in those with seemingly “excellent” weight reduction. To improve long-term weight loss outcome and future health, a multidisciplinary approach focusing on mental health and nutrition is essential for patients undergoing bariatric surgery.
    Materialart: Online-Ressource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000509342
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 2455819-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Preoperative Plasma Aldosterone Predicts Complete Remission of Type 2 Diabetes after Bariatric Surgery
    S. Karger AG ; 2022
    In:  Obesity Facts Vol. 15, No. 3 ( 2022), p. 373-383
    Details
    In: Obesity Facts, S. Karger AG, Vol. 15, No. 3 ( 2022), p. 373-383
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44–52%, 20–40%, and 19–25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insufficient improvement 1 year after BS. It is thus important to predict the improvement in type 2 diabetes before BS. Many hormones are related to hyperglycemia. However, the relationship between hormones and improvement in type 2 diabetes after BS has not been studied. We aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent BS. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively reviewed 79 patients with obesity and type 2 diabetes who underwent BS, with a follow-up period of 12 months. We analyzed the relationship between some clinical parameters and complete remission (CR) of type 2 diabetes after BS. Patients were divided into two groups (type 2 diabetes CR and non-CR). Multiple regression analysis was performed to determine the parameters associated with type 2 diabetes resolution after BS. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 BS significantly improved body weight and glucose metabolism. Preoperative liver function, glycated hemoglobin (HbA1c), insulin secretion (homeostatic model assessment [HOMA]2-%B), renin activity, plasma aldosterone level, and duration of type 2 diabetes were significantly different between the CR and non-CR groups. Multiple regression analysis showed that preoperative HbA1c, HOMA2-%B, aldosterone concentration, and duration of type 2 diabetes were predictors of CR of type 2 diabetes after BS. Plasma aldosterone was the strongest predictor. 〈 b 〉 〈 i 〉 Discussion/Conclusion: 〈 /i 〉 〈 /b 〉 Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.
    Materialart: Online-Ressource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000521855
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2022
    ZDB Id: 2455819-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Soluble (Pro)Renin Receptor Level in Patients with Severe Obesity Is Associated with Visceral Adiposity and Is Involved with Insulin Resistance and Renal Injury
    S. Karger AG ; 2023
    In:  Obesity Facts Vol. 16, No. 4 ( 2023), p. 335-343
    Details
    In: Obesity Facts, S. Karger AG, Vol. 16, No. 4 ( 2023), p. 335-343
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 High soluble (pro)renin receptor (s[P]RR) level in circulation is reported in obese patients; however, it is unclear which body composition components are responsible for it. In this study, the authors examined blood s(P)RR levels and ATP6AP2 gene expression levels in visceral and subcutaneous adipose tissue (VAT, SAT) in severely obese patients who underwent laparoscopic sleeve gastrectomy (LSG), with the aim of clarifying the relationship with body composition and metabolic factors. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Seventy five cases who underwent LSG between 2011 and 2015 and were postoperatively followed-up for 12 months at the Toho University Sakura Medical Center were included in the analysis of the cross-sectional survey at baseline, and 33 cases were included in the analysis of the longitudinal survey during the 12 months after LSG. We evaluated body composition, glycolipid parameters, liver/renal function, as well as serum s(P)RR level and ATP6AP2 mRNA expression level in VAT and SAT. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The mean serum s(P)RR level at baseline was 26.1 ng/mL, this value was considered higher than values in healthy subjects. There was no significant difference in the expression level of ATP6AP2 mRNA between VAT and SAT. At baseline, multiple regression analysis for the association between s(P)RR and variables identified that visceral fat area, HOMA2-IR, and UACR showed the independent relationships with s(P)RR. During the 12 months after LSG, body weight, serum s(P)RR level showed a significant decrease (from 30.0 ± 7.0 to 21.9 ± 4.3). Multiple regression analysis for the association between the change in s(P)RR and variables showed that changes in visceral fat area, and alanine transaminase were independently related to the change in s(P)RR. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This study showed that blood s(P)RR level was high in severely obese patients, decreased with weight loss by LSG, and was associated with visceral fat area in both pre- and postoperative changes. The results suggest that blood s(P)RR levels in obese patients may reflect the involvement of visceral adipose (P)RR in insulin resistance and renal damage mechanisms associated with obesity.
    Materialart: Online-Ressource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000531076
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2023
    ZDB Id: 2455819-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Relationship between Lipoprotein Lipase Derived from Subcutaneous Adipose Tissue and Cardio-Ankle Vascular Index in Japanese Patients with Severe Obesity
    S. Karger AG ; 2024
    In:  Obesity Facts
    Details
    In: Obesity Facts, S. Karger AG
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Cardio-ankle vascular index (CAVI) is an arterial stiffness index that correlates inversely with body mass index (BMI) and subcutaneous fat area. Lipoprotein lipase (LPL) that catalyzes the hydrolysis of serum triglycerides is produced mainly in adipocytes. Serum LPL mass reflects LPL expression in adipose tissue, and its changes correlate inversely with changes in CAVI. We hypothesized that LPL derived from subcutaneous adipose tissue (SAT) suppresses the progression of arteriosclerosis and examined the relationship of LPL gene expression in different adipose tissues and serum LPL mass with CAVI in Japanese patients with severe obesity undergoing laparoscopic sleeve gastrectomy (LSG). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This study was a single-center retrospective database analysis. Fifty Japanese patients who underwent LSG and had 1-year postoperative follow-up data were enrolled (mean age 47.5 years, baseline BMI 46.6 kg/m 〈 sup 〉 2 〈 /sup 〉 , baseline HbA1c 6.7%). SAT and visceral adipose tissue (VAT) samples were obtained during LSG surgery. LPL gene expression was analyzed by real-time PCR. Serum LPL mass was measured by ELISA using a specific monoclonal antibody against LPL. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At baseline, LPL mRNA expression in SAT correlated positively with serum LPL mass, but LPL mRNA expression in VAT did not. LPL mRNA expression in SAT was correlated, and serum LPL mass tended to correlate inversely with the number of metabolic syndrome symptoms, but LPL mRNA expression in VAT did not. LPL mRNA expression in SAT and CAVI tended to correlate inversely in the group with visceral-to-subcutaneous fat ratio of 0.4 or higher, which is considered metabolically severe. Serum LPL mass increased 1 year after LSG. Change in serum LPL mass at 1 year after LSG tended to be an independent factor inversely associated with change in CAVI. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Serum LPL mass reflected LPL mRNA expression in SAT in Japanese patients with severe obesity, and LPL mRNA expression in SAT was associated with CAVI in patients with visceral obesity. The change in serum LPL mass after LSG tended to independently contribute inversely to the change in CAVI. This study suggests that LPL derived from SAT may suppress the progression of arteriosclerosis.
    Materialart: Online-Ressource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000537687
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2024
    ZDB Id: 2455819-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Esophageal Metastasis from Rectal Cancer Successfully Treated with Fluorouracil-Based Chemotherapy with Bevacizumab: A Case Report and Review of the Literature
    S. Karger AG ; 2017
    In:  Case Reports in Oncology Vol. 10, No. 2 ( 2017-5-5), p. 407-415
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 10, No. 2 ( 2017-5-5), p. 407-415
    Kurzfassung: Esophageal metastasis from colorectal carcinoma is uncommon, and diagnosis of esophageal metastasis is difficult. We report a case of a 54-year-old woman with postoperative recurrence of rectal cancer metastasizing to the esophagus. She underwent rectectomy and adjuvant chemotherapy with fluorouracil, leucovorin plus oxaliplatin for stage IIIB rectal cancer. Three years later, she presented with dysphagia and cough. Computed tomography showed thickening of the esophagus wall, enlargement of the lymph nodes in the mediastinum and abdomen, and ground-glass opacities in the right lung. Endoscopy revealed a submucosal tumor of the midthoracic esophagus. Histopathological analysis of the tumor biopsy showed infiltration of adenocarcinoma cells into the stroma of the esophagus; tumor cells were positive for caudal type homeobox 2 and negative for thyroid transcription factor 1. A transbronchial biopsy indicated pulmonary lymphangitic carcinomatosis of rectal adenocarcinoma. Based on those findings, she was diagnosed with recurrent rectal cancer. She received fluorouracil-based chemotherapy plus bevacizumab, which ameliorated her symptoms and induced a durable response without severe adverse events. Diagnosis of esophageal metastasis from rectal cancer can thus be made by repeated biopsy. Furthermore, aggressive systemic treatment with fluorouracil-containing chemotherapy and bevacizumab is a treatment option for colorectal cancer patients with esophageal metastasis.
    Materialart: Online-Ressource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000474939
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2017
    ZDB Id: 2458961-5
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  • 7
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    Tofacitinib as Induction and Maintenance Therapy in Japanese Patients with Active Ulcerative Colitis
    S. Karger AG ; 2019
    In:  Inflammatory Intestinal Diseases Vol. 4, No. 4 ( 2019), p. 131-143
    Details
    In: Inflammatory Intestinal Diseases, S. Karger AG, Vol. 4, No. 4 ( 2019), p. 131-143
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Tofacitinib is an oral, small molecule Janus kinase inhibitor approved in Japan for the treatment of ulcerative colitis (UC). Differences in the safety profile of tofacitinib in Japanese patients versus the global population, such as a higher risk of herpes zoster, have been reported. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 We conducted post hoc analyses of tofacitinib treatment in Japanese patients with moderate-to-severe UC in two global phase III studies. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In OCTAVE Induction 1 (NCT01465763), 62 patients were randomized to placebo or tofacitinib 10 mg twice daily (b.i.d.). In OCTAVE Sustain (NCT01458574), 39 patients with clinical response in OCTAVE Induction 1 were re-randomized to placebo, tofacitinib 5 mg, or 10 mg b.i.d. Efficacy endpoints included: remission (primary endpoint; total Mayo score ≤2; no individual subscore & #x3e;1; rectal bleeding subscore 0); mucosal healing (Mayo endoscopic subscore ≤1); clinical response (≥30% and ≥3-point decrease from induction study baseline total Mayo score; decrease in rectal bleeding subscore ≥1 or absolute subscore ≤1). Adverse events (AEs) and clinical laboratory parameters were recorded. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At week 8 of OCTAVE Induction 1, 22.4% of patients achieved remission with tofacitinib (placebo, 7.7%). At week 52 of OCTAVE Sustain, 31.3% and 66.7% of patients receiving tofacitinib 5 and 10 mg b.i.d., respectively, achieved remission (placebo, 9.1%). The occurrence of AEs or serious AEs in Japanese patients was generally similar to that in the global study population, with no new or unexpected safety risks observed. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Although patient numbers were small, tofacitinib demonstrated numerically greater efficacy versus placebo among Japanese patients in OCTAVE Induction 1 and OCTAVE Sustain, with a safety profile consistent with that of the global study population.
    Materialart: Online-Ressource
    ISSN: 2296-9403 , 2296-9365
    URL: Article
    DOI: 10.1159/000502144
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2019
    ZDB Id: 2817967-5
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy
    S. Karger AG ; 2021
    In:  Obesity Facts Vol. 14, No. 6 ( 2021), p. 633-640
    Details
    In: Obesity Facts, S. Karger AG, Vol. 14, No. 6 ( 2021), p. 633-640
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Laparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A significant decrease was observed in the patients’ BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG. 〈 b 〉 〈 i 〉 Discussion/Conclusion: 〈 /i 〉 〈 /b 〉 These results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG.
    Materialart: Online-Ressource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000519410
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2021
    ZDB Id: 2455819-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Effect of Conventional Medical Therapy or Laparoscopic Sleeve Gastrectomy on Urinary Albumin in Japanese Subjects with Severe Obesity: An Observational Study
    S. Karger AG ; 2021
    In:  Obesity Facts Vol. 14, No. 6 ( 2021), p. 613-621
    Details
    In: Obesity Facts, S. Karger AG, Vol. 14, No. 6 ( 2021), p. 613-621
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 In patients with severe obesity, albuminuria can be improved by both conventional medical therapy and bariatric surgery. The purpose of this study was to compare the impact of weight loss achieved through conventional medical therapy or laparoscopic sleeve gastrectomy (LSG) on albuminuria in Japanese subjects with severe obesity and identify the factors involved. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively evaluated the clinical characteristics including the urinary albumin/creatinine ratio (UACR) of 340 consecutive subjects with a body mass index ≥35 who received LSG ( 〈 i 〉 n 〈 /i 〉 = 242) or medical therapy ( 〈 i 〉 n 〈 /i 〉 = 98) between 2010 and 2018 and were followed for at least 12 months. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The baseline of the UACR was not different between the 2 groups. At the 12-month follow-up, total weight loss (TWL) and decreases in glycosylated hemoglobin (HbA1c) and log 〈 sub 〉 e 〈 /sub 〉 UACR were greater in the LSG group than in the medical therapy group (body weight; −35.7 kg vs. −8.0 kg, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, HbA1c; −1.4% vs. −0.7%, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, log 〈 sub 〉 e 〈 /sub 〉 UACR; −0.3 vs. 0.9, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). The rate of complete remission of diabetes was significantly higher in the LSG group than in the medical therapy group. At 12 and 36 months ( 〈 i 〉 n 〈 /i 〉 = 111 in the medical therapy group, 〈 i 〉 n 〈 /i 〉 = 56 in the LSG group at 36 months), log 〈 sub 〉 e 〈 /sub 〉 UACR increased in the medical therapy group, while it remained unchanged or decreased in the LSG group. In subjects with microalbuminuria and macroalbuminuria, changes in the log 〈 sub 〉 e 〈 /sub 〉 UACR correlated with percent total body weight loss (%TWL) in both groups at 12 months. Percent TWL contributed independently to the change in the log 〈 sub 〉 e 〈 /sub 〉 UACR, irrespective of whether LSG was performed. In receiver-operating characteristic analysis, a weight loss of 7.8% predicted a decrease in the UACR (∆UACR & #x3c;0 at 12 months). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our analysis suggests that albuminuria may increase over time if only medical therapy is continued. To improve albuminuria, weight loss may be more important than whether LSG is performed.
    Materialart: Online-Ressource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000519156
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2021
    ZDB Id: 2455819-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Laparoscopic Sleeve Gastrectomy Significantly Increases Serum Lipoprotein Lipase Level in Obese Patients
    S. Karger AG ; 2019
    In:  Obesity Facts Vol. 12, No. 3 ( 2019), p. 357-368
    Details
    In: Obesity Facts, S. Karger AG, Vol. 12, No. 3 ( 2019), p. 357-368
    Kurzfassung: 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Obesity is one of the causes of metabolic disorders. Laparoscopic sleeve gastrectomy (LSG) confers beneficial effects not only on body weight (BW) but also on metabolic disorders. The lipoprotein lipase (LPL) level in preheparin serum is associated with visceral adipose tissue and reflects insulin resistance. However, the change in serum preheparin LPL levels after LSG remains unclear. This study aimed to examine the effect of LSG on preheparin LPL level in obese patients compared with nonsurgical treatment. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We retrospectively reviewed a total of 100 obese patients who were treated for obesity and had preheparin LPL levels measured before and 12 months after LSG or after 12 months of nonsurgical treatment. Fifty-six patients received LSG (LSG group), and 44 patients had no surgical treatment (nonsurgical group). We compared clinical parameters such as body mass index (BMI), hemoglobin A 〈 sub 〉 1c 〈 /sub 〉 (HbA 〈 sub 〉 1c 〈 /sub 〉 ), and preheparin LPL level before and 12 months after treatment. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 BMI and HbA 〈 sub 〉 1c 〈 /sub 〉 decreased significantly in both groups, but decreases in both parameters were greater in the LSG group than in the nonsurgical group. Estimated glomerular filtration was significantly improved only in the LSG group. Preheparin LPL level increased significantly only in the LSG group (from 45.8 ± 21.6 to 75.0 ± 34.9 ng/mL, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). Multiple regression identified LSG and decreased BMI as independent predictors of preheparin LPL level increase. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 These results suggest that LSG independently increases pre­heparin LPL level beyond BW reduction in obese patients.
    Materialart: Online-Ressource
    ISSN: 1662-4025 , 1662-4033
    URL: Article
    DOI: 10.1159/000500360
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2019
    ZDB Id: 2455819-9
    Standort Signatur Einschränkungen Verfügbarkeit
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