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  • 1
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    Nukleinsäure-Amplifikationstests für HIV, HBV und HCV bei Gewebespendern: Sinnvoll oder überflüssig?
    S. Karger AG ; 2008
    In:  Transfusion Medicine and Hemotherapy Vol. 35, No. 6 ( 2008), p. 421-430
    Details
    In: Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 35, No. 6 ( 2008), p. 421-430
    Materialart: Online-Ressource
    ISSN: 1660-3796 , 1660-3818
    URL: Article
    DOI: 10.1159/000165779
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2008
    ZDB Id: 2100533-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Cloning of the Swelling-Dependent Chloride Channel l〈sub〉Cln〈/sub〉 Homologue from Zebra Fish
    S. Karger AG ; 1997
    In:  Cellular Physiology and Biochemistry Vol. 7, No. 5 ( 1997), p. 298-302
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 7, No. 5 ( 1997), p. 298-302
    Materialart: Online-Ressource
    ISSN: 1421-9778 , 1015-8987
    URL: Article
    DOI: 10.1159/000154885
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 1997
    ZDB Id: 1482056-0
    SSG: 12
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Activity of Rituximab plus Cyclophosphamide, Doxorubicin/Mitoxantrone, Vincristine and Prednisone in Patients with Relapsed MALT Lymphoma
    S. Karger AG ; 2006
    In:  Oncology Vol. 70, No. 6 ( 2006), p. 411-417
    Details
    In: Oncology, S. Karger AG, Vol. 70, No. 6 ( 2006), p. 411-417
    Kurzfassung: 〈 i 〉 Background: 〈 /i 〉 Various chemotherapeutic agents as well as the anti-CD20 antibody rituximab (R) have been tested in patients with mucosa-associated lymphoid tissue (MALT) lymphoma, but no standard chemotherapeutic regimen has emerged so far. Judging from the data obtained in various types of lymphoma, the activity of R appears to be enhanced by combination with chemotherapy. As no data on this topic exist for MALT lymphoma, we have retrospectively analysed our experience with R plus cyclophosphamide, doxorubicin/mitoxantrone, vincristine and prednisone (R-CHOP/R-CNOP) in patients with relapsed MALT lymphoma. 〈 i 〉 Patients and Methods: 〈 /i 〉 A total of 26 patients were identified, 15 were administered R-CHOP while 11 patients were given R-CNOP due to age 〉 65 years or pre-existing cardiac conditions. Cycles were repeated every 21 days, and restaging was performed after 4 cycles of therapy. In case of complete remission, 2 further cycles were administered for consolidation while patients achieving partial remission or stable disease after restaging were given 4 further courses. 〈 i 〉 Results: 〈 /i 〉 A total of 170 cycles were administered to our patients (median 6, range 2–8). Twenty of the 26 patients (77%) achieved a complete remission and 6 (23%) a partial remission. Toxicities were mainly haematological, with WHO grade III/IV leukocytopenia occurring in 5 patients. After a median follow-up of 19 months (range 10–45), all patients are alive: 22 are in ongoing remission, while 4 have relapsed between 12 and 19 months after treatment. 〈 i 〉 Conclusions: 〈 /i 〉 Our data demonstrate a high activity of R-CHOP/R-CNOP in relapsing MALT lymphoma irrespective of prior therapy.
    Materialart: Online-Ressource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000098555
    RVK:
    XH 3305
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2006
    ZDB Id: 1483096-6
    ZDB Id: 250101-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    In vivo and in vitro Effects of Glucocorticoids on Lymphocyte Proliferation in Man: Relationship to Glucocorticoid Receptors
    S. Karger AG ; 1990
    In:  Neuropsychobiology Vol. 24, No. 2 ( 1990), p. 61-66
    Details
    In: Neuropsychobiology, S. Karger AG, Vol. 24, No. 2 ( 1990), p. 61-66
    Materialart: Online-Ressource
    ISSN: 0302-282X , 1423-0224
    URL: Article
    DOI: 10.1159/000119462
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 1990
    ZDB Id: 1483094-2
    SSG: 5,2
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Long-Term Follow-Up of Patients after Intraarterial Thrombolytic Therapy of Acute Vertebrobasilar Artery Occlusion
    S. Karger AG ; 2001
    In:  Cerebrovascular Diseases Vol. 12, No. 3 ( 2001), p. 214-219
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 12, No. 3 ( 2001), p. 214-219
    Kurzfassung: Local thrombolysis may reduce mortality after acute vertebrobasilar artery occlusion. We focused on variables affecting recanalization, outcome and long-term prognosis. Thirty-six patients with vertebrobasilar artery occlusion were treated with local intraarterial thrombolytic therapy. Four of the survivors were among the 16 patients without recanalization. Recanalization was associated with a higher survival rate. Top-of-the-basilar-type occlusions have the highest recanalization rate. The thrombolytic medication used did not influence the recanalization frequency. One patient died due to an intracerebral bleed after thrombolysis. There was no association between the time interval (greater or less than 6 h) between the onset of symptoms and therapy initiation and survival. Relapses during follow-up (mean follow-up 3.7 years) did not occur. MRI/MRA and ultrasound studies during follow-up showed unchanged results in these patients. All survivors at the time of follow-up lived at home.
    Materialart: Online-Ressource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000047706
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2001
    ZDB Id: 1482069-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Morphology of Pilonidal Sinus Disease: Some Evidence of Its Being a Unilocalized Type of Hidradenitis Suppurativa
    S. Karger AG ; 2011
    In:  Dermatology Vol. 223, No. 4 ( 2011), p. 349-355
    Details
    In: Dermatology, S. Karger AG, Vol. 223, No. 4 ( 2011), p. 349-355
    Kurzfassung: 〈 i 〉 Background: 〈 /i 〉 The term ‘pilonidal sinus’ (PS) reflects an acute exacerbating, purulent, fistulating chronic inflammation located in the coccyx region. Systematic histological investigations are scarce, and the etiology has remained controversial. 〈 i 〉 Methods: 〈 /i 〉 Histological and immunohistochemical characterization of totally excised material of 27 patients (68 specimens) with PS (no antecedent and no current clinical signs of hidradenitis suppurativa, HS) and its correlation with data on HS which we published earlier. 〈 i 〉 Results: 〈 /i 〉 Follicular hyperplasia/hyperkeratosis and interfollicular epidermal hyperplasia are main features of PS. Early pathology seems to take place at terminal hair follicles, whereas sinus tract formations are a secondary event. Focused regions show an inflammatory mixed infiltrate consisting of CD3+, CD4+, CD8+, CD68+ and CD79+ cells. 〈 i 〉 Conclusions: 〈 /i 〉 PS and HS have various common characteristics at the histological and immunohistochemical level. Considering PS as a unilocalized type of HS, risk factors known in the latter should henceforth be evaluated in PS as well.
    Materialart: Online-Ressource
    ISSN: 1018-8665 , 1421-9832
    URL: Article
    DOI: 10.1159/000335373
    RVK:
    XA 37700
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2011
    ZDB Id: 1482189-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    Excess Body Weight and Abdominal Hernia
    S. Karger AG ; 2021
    In:  Visceral Medicine Vol. 37, No. 4 ( 2021), p. 246-253
    Details
    In: Visceral Medicine, S. Karger AG, Vol. 37, No. 4 ( 2021), p. 246-253
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Obese patients have an increased incidence of ventral hernias; in over 50% of these cases, patients are symptomatic. At the same time, morbid obesity is a disease of epidemic proportions. The combination of symptomatic hernia and obesity is a challenge for the treating surgeon, because the risk of perioperative complications and recurrence increases with increasing BMI. 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 This review outlines this problem and discusses interdisciplinary approaches to the management of affected patients. In emergency cases, the hernia is treated according to the surgeon’s expertise. In elective cases, an individual decision must be made whether bariatric surgery is indicated before hernia repair or whether both should be performed simultaneously. After bariatric surgery a weight reduction of 25–30% of total body weight in the first year can be achieved and it is often advantageous to perform a bariatric operation prior to hernia repair. Technically, the risk of complications is lower with minimally invasive procedures than with open ones, but laparoscopy is challenging in obese patients, and meshes can only be implanted in intraperitoneal position. This mesh position has to be questioned because of adhesions, recurrence rate, and risk of contamination during re-interventions in patients who are often still relatively young. 〈 b 〉 〈 i 〉 Key Messages: 〈 /i 〉 〈 /b 〉 Obese patients with hernia need to be approached in an interdisciplinary manner, in some patients a weight loss procedure may be advantageous before hernia repair. Recent data show the benefits of robotic hernia surgery in obese patients, as not only haptic advantages result, but especially the mesh can be implanted in a variety of extraperitoneal positions in the abdominal wall with low morbidity.
    Materialart: Online-Ressource
    ISSN: 2297-4725 , 2297-475X
    URL: Article
    DOI: 10.1159/000516047
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2021
    ZDB Id: 2850734-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Fermentative Cyclohexane Carboxylate Formation in 〈b〉〈i〉Syntrophus aciditrophicus〈/i〉〈/b〉
    S. Karger AG ; 2016
    In:  Microbial Physiology Vol. 26, No. 1-3 ( 2016), p. 165-179
    Details
    In: Microbial Physiology, S. Karger AG, Vol. 26, No. 1-3 ( 2016), p. 165-179
    Kurzfassung: Short-chain fatty acids such as acetic, propionic, butyric or lactic acids are typical primary fermentation products in the anaerobic feeding chain. Fifteen years ago, a novel fermentation type was discovered in the obligately anaerobic Deltaproteobacterium 〈 i 〉 Syntrophus aciditrophicus 〈 /i 〉 . During fermentative growth with crotonate and/or benzoate, acetate is formed in the oxidative branch and cyclohexane carboxylate in the reductive branch. In both cases cyclohexa-1,5-diene-1-carboxyl-CoA (Ch1,5CoA) is a central intermediate that is either formed by a class II benzoyl-CoA reductase (fermentation of benzoate) or by reverse reactions of the benzoyl-CoA degradation pathway (fermentation of crotonate). Here, we summarize the current knowledge of the enzymology involved in fermentations yielding cyclohexane carboxylate as an excreted product. The characteristic enzymes involved are two acyl-CoA dehydrogenases specifically acting on Ch1,5CoA and cyclohex-1-ene-1-carboxyl-CoA. Both enzymes are also employed during the syntrophic growth of 〈 i 〉 S. aciditrophicus 〈 /i 〉 with cyclohexane carboxylate as the carbon source in coculture with a methanogen. An investigation of anabolic pathways in 〈 i 〉 S. aciditrophicus 〈 /i 〉 revealed a rather unusual pathway for glutamate synthesis involving a 〈 i 〉 Re 〈 /i 〉 -citrate synthase. Future work has to address the unresolved question concerning which components are involved in reoxidation of the NADH formed in the oxidative branch of the unique cyclohexane carboxylate fermentation pathway in 〈 i 〉 S. aciditrophicus 〈 /i 〉 .
    Materialart: Online-Ressource
    ISSN: 2673-1665 , 2673-1673
    URL: Article
    DOI: 10.1159/000440881
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2016
    ZDB Id: 3042601-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Donor Hemovigilance with Blood Donation
    S. Karger AG ; 2015
    In:  Transfusion Medicine and Hemotherapy Vol. 42, No. 3 ( 2015), p. 181-192
    Details
    In: Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 42, No. 3 ( 2015), p. 181-192
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Reports on unexpected events (UEs) during blood donation (BD) inadequately consider the role of technical UEs. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Defined local and 〈 b 〉 〈 /b 〉 systemic UEs were graded by severity; technical UEs were not graded. On January 1, 2008, E.B.P.S.-Logistics (EBPS) installed the UE module for plasma management software (PMS). Donor room physicians entered UEs daily into PMS. Medical directors reviewed entries quarterly. EBPS compiled data on donors, donations, and UEs from January 1, 2008 to June 30, 2011. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 6,605 UEs were observed during 166,650 BDs from 57,622 donors for a corrected incidence of 4.30% (0.66% local, 1.59% systemic, 2.04% technical UEs). 2.96% of BDs were accompanied by one UE and 0.45% by 〉 1 UE (2-4). 6.3% of donors donating blood for their first time, 3.5% of those giving blood for their second time, and 1.9% of donors giving their third or more BD experienced UEs. Most common UEs were: discontinued collections due to venous access problems, repeated venipuncture, and small hematomas. Severe circulatory UEs occurred at a rate of 16 per 100,000 BDs. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Technical UEs were common during BD. UEs accompanied first and second donations significantly more often than subsequent donations.
    Materialart: Online-Ressource
    ISSN: 1660-3796 , 1660-3818
    URL: Article
    DOI: 10.1159/000371614
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2015
    ZDB Id: 2100533-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    High In-Hospital Mortality in SARS-CoV-2-Infected Patients with Active Cancer Disease during Omicron Phase of the Pandemic: Insights from the CORONA Germany Study
    S. Karger AG ; 2023
    In:  Oncology Research and Treatment Vol. 46, No. 5 ( 2023), p. 201-210
    Details
    In: Oncology Research and Treatment, S. Karger AG, Vol. 46, No. 5 ( 2023), p. 201-210
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 SARS-CoV-2 infected patients with cancer have a worse outcome including a significant higher mortality, compared to non-cancer patients. However, limited data are available regarding in-hospital mortality during the Omicron phase of the pandemic. Therefore, the aim of the study was the comparison of mortality in patients with history of cancer and patients with active cancer disease during the different phases of the COVID-19 pandemic, focusing on the current Omicron variant of concern. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We conducted a multicenter, observational, epidemiological cohort study at 45 hospitals in Germany. Until July 20, 2022, all adult hospitalized SARS-CoV-2 positive patients were included. The primary endpoint was in-hospital mortality regarding cancer status (history of cancer and active cancer disease) and SARS-CoV-2 virus type. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 From March 11, 2020, to July 20, 2022, a total of 27,490 adult SARS-CoV-2 positive patients were included in the study. 2,578 patients (9.4%) had diagnosis of cancer, of whom 1,065 (41.3%) had history of cancer, whereas 1,513 (58.7%) had active cancer disease. Overall 3,749 out of the total of 27,490 patients (13.6%) died during the hospital stay. Patients with active cancer disease had a significantly higher mortality compared to patients without cancer diagnosis, in both phases of the pandemic (wild-type to Delta: OR 1.940 [1.646–2.285]); Omicron: 2.864 [2.354–3.486] ). After adjustment to co-variables, SARS-CoV-2 infected patients with active cancer disease had the highest risk for in-hospital mortality compared to the other groups, in both phases of the pandemic. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The CORONA Germany study indicates that hospitalized patients with active cancer disease are at high risk of death during a SARS-CoV-2 infection. Mortality of patients with history of cancer improved to nearly the level of non-cancer patients during Omicron phase.
    Materialart: Online-Ressource
    ISSN: 2296-5270 , 2296-5262
    URL: Article
    DOI: 10.1159/000529788
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2023
    ZDB Id: 2749752-5
    Standort Signatur Einschränkungen Verfügbarkeit
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