In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2021-12-23), p. e0261703-
Kurzfassung:
Vonoprazan, a potassium-competitive acid blocker, is expected to be superior to proton pump inhibitors (PPIs) in preventing post-endoscopic submucosal dissection (ESD)-induced gastric bleeding. However, the results of randomized controlled trials (RCTs) and observational studies on the efficacy of vonoprazan have been inconsistent. This study aimed to evaluate the effectiveness of vonoprazan in antithrombotic drug users, a population that has been excluded from RCTs. Treatment effects were assessed using cross-design synthesis, which can be adjusted for differences in study design and patient characteristics. We used data from an RCT in Japan (70 patients in the vonoprazan group and 69 in the PPI group) and an observational study (408 patients in the vonoprazan group and 870 in the PPI group). After matching, among the antithrombotic drug users in the observational study, post-ESD bleeding was noted in 8 out of 86 patients in the vonoprazan group and 18 out of 86 patients in the PPI group. After pooling the data from the RCT and observational study, the risk difference for antithrombotic drug users was -14.6% (95% CI: -22.0 to -7.2). CDS analysis suggested that vonoprazan is more effective than PPIs in preventing post-ESD bleeding among patients administered antithrombotic medications.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0261703
DOI:
10.1371/journal.pone.0261703.g001
DOI:
10.1371/journal.pone.0261703.g002
DOI:
10.1371/journal.pone.0261703.g003
DOI:
10.1371/journal.pone.0261703.t001
DOI:
10.1371/journal.pone.0261703.t002
DOI:
10.1371/journal.pone.0261703.t003
DOI:
10.1371/journal.pone.0261703.t004
DOI:
10.1371/journal.pone.0261703.t005
DOI:
10.1371/journal.pone.0261703.s001
DOI:
10.1371/journal.pone.0261703.s002
DOI:
10.1371/journal.pone.0261703.s003
DOI:
10.1371/journal.pone.0261703.s004
DOI:
10.1371/journal.pone.0261703.r001
DOI:
10.1371/journal.pone.0261703.r002
DOI:
10.1371/journal.pone.0261703.r003
DOI:
10.1371/journal.pone.0261703.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2267670-3
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