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  • Oxford University Press (OUP)  (11)
  • 1
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2019
    In:  Journal of AOAC INTERNATIONAL Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    In: Journal of AOAC INTERNATIONAL, Oxford University Press (OUP), Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    Abstract: Background: Polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) are classes of contaminants that are present in the environment and food. They pose a great threat to human health because of their carcinogenicity and mutagenicity. Very few studies have focused on their concentration in waste cooking oil (WCO) and oil deodorizer distillate (ODD). Objective: This study aimed (1) to design a reliable method to determine 16 PAHs and 4 OPAHs in both WCO and ODD and (2) to determine and analyze PAH and OPAH concentrations in actual samples to provide references for further research. Method: The PAH determination approach included double liquid–liquid extraction, double solid-phase extraction, and GC–triple quadrupole tandem MS determination. Oxidation indices were determined by titrimetry. Results: The method reached good linearity (R2 & gt; 0.99) and an acceptable recovery rate (55.01–126.16% for WCO and 57.48–128.97% for ODD). Ten WCO and five ODD samples were determined, and the total concentration of 16 PAHs varied from 16.34 to 239.01 and 101.08 to 198.04 μg/kg in WCO and ODD, respectively. Among the 16 PAHs, three-ring PAHs typically contributed the most. It was also found that the acid value has a strong correlation with the concentration of OPAHs, probably because of the contribution of free fatty acids to OPAH formation. Conclusions: The proposed method was effective in the analysis of PAHs and OPAHs in WCO and ODD.
    Type of Medium: Online Resource
    ISSN: 1060-3271 , 1944-7922
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 2
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2014
    In:  Human Molecular Genetics Vol. 23, No. 14 ( 2014-07-15), p. 3792-3800
    In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 23, No. 14 ( 2014-07-15), p. 3792-3800
    Type of Medium: Online Resource
    ISSN: 1460-2083 , 0964-6906
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2014
    detail.hit.zdb_id: 1474816-2
    SSG: 12
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  • 3
    In: National Science Review, Oxford University Press (OUP), Vol. 10, No. 7 ( 2023-05-31)
    Abstract: Reversible transformations between fractals and periodic structures are of fundamental importance for understanding the formation mechanism of fractals. Currently, it is still a challenge to controllably achieve such a transformation. We investigate the effect of CO and CO2 molecules on Sierpiński triangles (STs) assembled from Fe atoms and 4,4″-dicyano-1,1′:3′,1″-terphenyl (C3PC) molecules on Au surfaces. Using scanning tunneling microscopy, we discover that the gas molecules induce a transition from STs into 1D chains. Based on density functional theory modeling, we propose that the atomistic mechanism involves the transformation of a stable 3-fold coordination Fe(C3PC)3 motif to Fe(C3PC)4 with an axially bonded CO molecule. CO2 causes the structural transformation through a molecular catassembly process.
    Type of Medium: Online Resource
    ISSN: 2095-5138 , 2053-714X
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2745465-4
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  • 4
    In: Plant Physiology, Oxford University Press (OUP), Vol. 181, No. 3 ( 2019-11), p. 1223-1238
    Type of Medium: Online Resource
    ISSN: 0032-0889 , 1532-2548
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2004346-6
    detail.hit.zdb_id: 208914-2
    SSG: 12
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  • 5
    In: Rheumatology, Oxford University Press (OUP), Vol. 61, No. 5 ( 2022-05-05), p. 2176-2184
    Abstract: DM and clinically amyopathic DM (CADM) patients with positive expression of anti-transcription intermediary factor 1-γ (anti-TIF1-γ) antibody (Ab) are characterized by distinct clinicopathological features. We aimed to determine the role of cytokine/chemokine profiles in the classification of anti-TIF1-γ positive DM/CADM patients. Methods Serum levels of 24 cytokines/chemokines were measured in 27 anti-TIF1-γ positive DM/CADM patients by a Luminex 200 system. Principal components analysis and unsupervised hierarchical clustering were used to reduce variables and establish patient subgroups. Spearman’s correlation coefficient was calculated between cytokine/chemokine levels and disease activity markers. Results Among anti-TIF1-γ positive DM/CADM patients, two distinct patient clusters were identified. The diagnosis of CADM was more common in cluster 1 than in cluster 2 (58.3% vs 6.7%, P = 0.008). Skin disease activity was higher in cluster 2 than in cluster 1 as measured by Cutaneous DM Disease Area and Severity Index–Activity [38.6  (10.4) vs 25.3  (10.0), P = 0.003]. Patients within cluster 2 exhibited significant muscle weakness (Medical Research Council scale ≤ 3, 33.3% vs 0.0%, P = 0.047), higher levels of anti-TIF1-γ Ab [92.4  (20.6) vs 66.9  (13.9), P = 0.001] and an increased malignancy rate (73.3% vs 25.0%, P = 0.021). Cluster 2 exhibited higher serum levels of CXCL10 [564.2  (258.8) vs 122.0  (97.8), P  & lt; 0.001], CCL2 [1136.6  (545.4) vs 441.6  (163.3), P  & lt; 0.001], galectin-9 [38879.6  (20009.3) vs 12612.4  (6640.0), P  & lt; 0.001], IL-18 [436.1  (188.9) vs 243.0  (114.5), P = 0.003] , TNF-α [9.3  (3.8) vs 5.6  (2.4), P = 0.007] and TNFRI [1385.1  (338.2) vs 2605.6  (928.5), P  & lt; 0.001] than cluster 1. Conclusion In anti-TIF1-γ positive DM/CADM, we identified a ‘skin-predominant’ cluster and a ‘hyperinflammation’ cluster based on the cytokine/chemokine profiles.Cytokine/chemokine profiles in anti-TIF1-γ positive DM/CADM can identify discrete clusters of patients with different disease patterns, organ involvements and clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 1462-0324 , 1462-0332
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1474143-X
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  • 6
    In: Journal of AOAC INTERNATIONAL, Oxford University Press (OUP), Vol. 102, No. 4 ( 2019-07-01), p. 1174-1180
    Abstract: Background: Cabernet Sauvignon wine enjoys large market in China, and its adulteration has become a well-known problem and challenge. Objective: This study aims to evaluate the capabilities of multiple techniques, including headspace–solid-phase microextraction–GC-MS (HS-SPME-GC-MS), electronic tongue (E-tongue) spectroscopy, mid-infrared (MIR) spectroscopy, and near-infrared (NIR) spectroscopy, to differentiate this popular imported wine in China. Methods: MIR spectroscopy, NIR spectroscopy, E-tongue spectroscopy, and HS-SPME-GC-MS were used. Multivariate analysis techniques were applied to further explore the instrumental determination data for the wine discrimination. Results: Joint use of MIR and NIR with Grey relational analysis (GRA), E-tongue with principal component analysis (PCA) and hierarchical cluster analysis, and HS-SPME-GC-MS with PCA allowed unanimous differentiation of the wines. Conclusions: The approach described herein offers both ecologically friendly and multiperspective mutual corroboration techniques for Cabernet Sauvignon wine discrimination. The integrative methodology could be used as a reference for wine authentication. Highlights: GRA was first applied to discriminate the wine samples. Mutual corroboration was verified by multivariate statistics combined with MIR, NIR, E-tongue, and SPME-GC/MS. Integrated techniques pointed to a unanimous authentication of the wine samples.
    Type of Medium: Online Resource
    ISSN: 1060-3271 , 1944-7922
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
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  • 7
    In: International Immunology, Oxford University Press (OUP), Vol. 31, No. 8 ( 2019-07-30), p. 499-514
    Abstract: Decreased levels of Faecalibacterium prausnitzii (F. prausnitzii), whose supernatant plays an anti-inflammatory effect, are frequently found in inflammatory bowel disease (IBD) patients. However, the anti-inflammatory products in F. prausnitzii supernatant and the mechanism have not been fully investigated. Here we found that F. prausnitzii and F. prausnitzii-derived butyrate were decreased in the intestines of IBD patients. Supplementation with F. prausnitzii supernatant and butyrate could ameliorate colitis in an animal model. Butyrate, but not other substances produced by F. prausnitzii, exerted an anti-inflammatory effect by inhibiting the differentiation of T helper 17 (Th17) cells. The mechanism underlying the anti-inflammatory effects of the butyrate produced by F. prausnitzii involved the enhancement of the acetylation-promoted degradation of c-Myc through histone deacetylase 3 (HDAC3) inhibition. In conclusion, F. prausnitzii produced butyrate to decrease Th17 differentiation and attenuate colitis through inhibiting HDAC3 and c-Myc-related metabolism in T cells. The use of F. prausnitzii may be an effective new approach to decrease the level of Th17 cells in the treatment of inflammatory diseases.
    Type of Medium: Online Resource
    ISSN: 1460-2377
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1467474-9
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  • 8
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2023
    In:  Journal of Experimental Botany Vol. 74, No. 15 ( 2023-08-17), p. 4670-4684
    In: Journal of Experimental Botany, Oxford University Press (OUP), Vol. 74, No. 15 ( 2023-08-17), p. 4670-4684
    Abstract: Autophagy functions in plant host immunity responses to pathogen infection. The molecular mechanisms and functions used by the citrus Huanglongbing (HLB)-associated intracellular bacterium ‘Candidatus Liberibacter asiaticus’ (CLas) to manipulate autophagy are unknown. We identified a CLas effector, SDE4405 (CLIBASIA_04405), which contributes to HLB progression. ‘Wanjincheng’ orange (Citrus sinensis) transgenic plants expressing SDE4405 promotes CLas proliferation and symptom expression via suppressing host immunity responses. SDE4405 interacts with the ATG8-family of proteins (ATG8s), and their interactions activate autophagy in Nicotiana benthamiana. The occurrence of autophagy is also significantly enhanced in SDE4405-transgenic citrus plants. Interrupting NbATG8s-SDE4405 interaction by silencing of NbATG8c reduces Pseudomonas syringae pv. tomato strain DC3000ΔhopQ1-1 (Pst DC3000ΔhopQ1-1) proliferation in N. benthamiana, and transient overexpression of CsATG8c and SDE4405 in citrus promotes Xanthomonas citri subsp. citri (Xcc) multiplication, suggesting that SDE4405-ATG8s interaction negatively regulates plant defense. These results demonstrate the role of the CLas effector protein in manipulating autophagy, and provide new molecular insights into the interaction between CLas and citrus hosts.
    Type of Medium: Online Resource
    ISSN: 0022-0957 , 1460-2431
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1466717-4
    SSG: 12
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  • 9
    In: Tree Physiology, Oxford University Press (OUP), ( 2023-09-26)
    Abstract: Interspecific variations in phenotypic plasticity of trees affected by climate change may alter ecosystem function of forests. Seedlings of four common tree species (Castanopsis fissa, Michelia macclurei, Dalbergia odorifera and Ormosia pinnata) in subtropical plantations of southern China were grown in the field under rainout shelters and subjected to changing precipitation (48 L water every 4 days in the dry season, 83 L water every 1 day in the wet season; 4 g m-2 yr-1 nitrogen (N)), low N deposition (48 L water every 2 days in the dry season, 71 L water every 1 day in the wet season; 8 g m-2 yr-1 N), high N deposition (48 L water every 2 days in the dry season, 71 L water every 1 day in the wet season; 10 g m-2 yr-1 N) and their interactive effects. We found that the changes in seasonal precipitation reduced the light-saturated photosynthetic rate (Asat) for C. fissa due to declining area-based foliar N concentrations (Na). However, we also found that the interactive effects of changing precipitation and N deposition enhanced Asat for C. fissa by increasing foliar Na concentrations, suggesting that N deposition could alleviate N limitations associated with changing precipitation. Altered precipitation and high N deposition reduced Asat for D. odorifera by decreasing the maximum electron transport rate for RuBP regeneration (Jmax) and maximum rate of carboxylation of Rubisco (Vcmax). O. pinnata under high N deposition exhibited increasing Asat due to higher stomatal conductance and Vcmax. The growth of D. odorifera might be inhibited by changes in seasonal precipitation and N deposition, while O. pinnata may benefit from increasing N deposition in future climates. Our study provides an important insight into the selection of tree species with high capacity to tolerate changing precipitation and N deposition in subtropical plantations.
    Type of Medium: Online Resource
    ISSN: 1758-4469
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1473475-8
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 2019
    In:  Journal of AOAC International Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    In: Journal of AOAC International, Oxford University Press (OUP), Vol. 102, No. 6 ( 2019-11-01), p. 1884-1891
    Abstract: Background: Polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) are classes of contaminants that are present in the environment and food. They pose a great threat to human health because of their carcinogenicity and mutagenicity. Very few studies have focused on their concentration in waste cooking oil (WCO) and oil deodorizer distillate (ODD). Objective: This study aimed ( 1 ) to design a reliable method to determine 16 PAHs and 4 OPAHs in both WCO and ODD and ( 2 ) to determine and analyze PAH and OPAH concentrations in actual samples to provide references for further research. Method: The PAH determination approach included double liquid–liquid extraction, double solid-phase extraction, and GC–triple quadrupole tandem MS determination. Oxidation indices were determined by titrimetry. Results: The method reached good linearity ( R 2 〉 0.99) and an acceptable recovery rate (55.01–126.16% for WCO and 57.48–128.97% for ODD). Ten WCO and five ODD samples were determined, and the total concentration of 16 PAHs varied from 16.34 to 239.01 and 101.08 to 198.04 μg/kg in WCO and ODD, respectively. Among the 16 PAHs, three-ring PAHs typically contributed the most. It was also found that the acid value has a strong correlation with the concentration of OPAHs, probably because of the contribution of free fatty acids to OPAH formation. Conclusions: The proposed method was effective in the analysis of PAHs and OPAHs in WCO and ODD.
    Type of Medium: Online Resource
    ISSN: 1060-3271
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    Location Call Number Limitation Availability
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